DNA defects target the centrosome.

abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

journal_title：Nature cell biology

authors： Delaunay S,Frye M

更新日期：2019-05-01 00:00:00

abstract：:Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. ...

journal_title：Nature cell biology

authors： Yahara Y,Barrientos T,Tang YJ,Puviindran V,Nadesan P,Zhang H,Gibson JR,Gregory SG,Diao Y,Xiang Y,Qadri YJ,Souma T,Shinohara ML,Alman BA

更新日期：2020-01-01 00:00:00

abstract：:During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...

journal_title：Nature cell biology

authors： Derynck R,Akhurst RJ

更新日期：2007-09-01 00:00:00

abstract：:Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating bot...

journal_title：Nature cell biology

authors： Le Bouteiller M,Jensen KB

更新日期：2015-01-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-renewal of PSC-HSPCs. Using two-step differentiation, human embryonic stem cells (hESCs) differentiated in vitro into multipotent haemat...

journal_title：Nature cell biology

authors： Dou DR,Calvanese V,Sierra MI,Nguyen AT,Minasian A,Saarikoski P,Sasidharan R,Ramirez CM,Zack JA,Crooks GM,Galic Z,Mikkola HK

更新日期：2016-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature cell biology

authors： Bagci H,Sriskandarajah N,Robert A,Boulais J,Elkholi IE,Tran V,Lin ZY,Thibault MP,Dubé N,Faubert D,Hipfner DR,Gingras AC,Côté JF

更新日期：2020-03-01 00:00:00

abstract：:LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...

journal_title：Nature cell biology

authors： Yang X,Yu K,Hao Y,Li DM,Stewart R,Insogna KL,Xu T

更新日期：2004-07-01 00:00:00

abstract：:The position of the mitotic spindle controls the plane of cell cleavage and determines whether polarized cells divide symmetrically or asymmetrically. In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and act...

journal_title：Nature cell biology

authors： Galli M,Muñoz J,Portegijs V,Boxem M,Grill SW,Heck AJ,van den Heuvel S

更新日期：2011-08-21 00:00:00

abstract：:The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in r...

journal_title：Nature cell biology

authors： Oberst A

更新日期：2017-09-29 00:00:00

abstract：:Proteins containing ubiquitin-binding domains (UBDs) interact with ubiquitinated targets and regulate diverse biological processes, including endocytosis, signal transduction, transcription and DNA repair. Many of the UBD-containing proteins are also themselves monoubiquitinated, but the functional role and the mechan...

journal_title：Nature cell biology

authors： Hoeller D,Crosetto N,Blagoev B,Raiborg C,Tikkanen R,Wagner S,Kowanetz K,Breitling R,Mann M,Stenmark H,Dikic I

更新日期：2006-02-01 00:00:00

abstract：:Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanis...

journal_title：Nature cell biology

authors： Birchmeier W

更新日期：2016-04-27 00:00:00

abstract：:Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these processes are important in many cells, few factors that regulate spindle placement are known. Previous work has shown that GPB-1, the Gbeta subunit of a hetero...

journal_title：Nature cell biology

authors： Gotta M,Ahringer J

更新日期：2001-03-01 00:00:00

abstract：:Cell-cell adhesion mediated by specific cell-surface molecules is essential for multicellular development. Here we quantify de-adhesion forces at the resolution of individual cell-adhesion molecules, by controlling the interactions between single cells and combining single-molecule force spectroscopy with genetic mani...

journal_title：Nature cell biology

authors： Benoit M,Gabriel D,Gerisch G,Gaub HE

更新日期：2000-06-01 00:00:00

abstract：:Starvation of animals or cells triggers autophagic degradation of cell contents to retrieve nutrients, but, paradoxically, mitochondria enlarge. This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1. Elongation of mitochondria optimizes ATP product...

journal_title：Nature cell biology

authors： Blackstone C,Chang CR

更新日期：2011-05-01 00:00:00

abstract：:Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...

journal_title：Nature cell biology

authors： Müller PM,Rademacher J,Bagshaw RD,Wortmann C,Barth C,van Unen J,Alp KM,Giudice G,Eccles RL,Heinrich LE,Pascual-Vargas P,Sanchez-Castro M,Brandenburg L,Mbamalu G,Tucholska M,Spatt L,Czajkowski MT,Welke RW,Zhang S,Ngu

更新日期：2020-04-01 00:00:00

abstract：:During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to undergo symmetric or asymmetric divisions, its role in mammalian neurogenesis remains unclear. Here we show that control of s...

journal_title：Nature cell biology

authors： Konno D,Shioi G,Shitamukai A,Mori A,Kiyonari H,Miyata T,Matsuzaki F

更新日期：2008-01-01 00:00:00

abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

journal_title：Nature cell biology

authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

更新日期：2017-08-01 00:00:00

abstract：:Whereas total loss of Lis1 is lethal, disruption of one allele of the Lis1 gene results in brain abnormalities, indicating that developing neurons are particularly sensitive to a reduction in Lis1 dosage. Here we show that Lis1 is enriched in neurons relative to levels in other cell types, and that Lis1 interacts with...

journal_title：Nature cell biology

authors： Smith DS,Niethammer M,Ayala R,Zhou Y,Gambello MJ,Wynshaw-Boris A,Tsai LH

更新日期：2000-11-01 00:00:00

abstract：:Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...

journal_title：Nature cell biology

authors： Tanaka T,Komai Y,Tokuyama Y,Yanai H,Ohe S,Okazaki K,Ueno H

更新日期：2013-05-01 00:00:00

abstract：:Recent theoretical analysis of a model lattice of interacting transmembrane receptor proteins has indicated that such clustering in the membrane could provide a novel mechanism for regulating receptor signalling in cells. It has been calculated that cooperative interactions between receptors organized into a cluster, ...

journal_title：Nature cell biology

authors： Yin CC,Lai FA

更新日期：2000-09-01 00:00:00

abstract：:Phosphatase and tensin homologue (Pten) suppresses neoplastic growth by negatively regulating PI(3)K signalling through its phosphatase activity. To gain insight into the actions of non-catalytic Pten domains in normal physiological processes and tumorigenesis, we engineered mice lacking the PDZ-binding domain (PDZ-BD...

journal_title：Nature cell biology

authors： van Ree JH,Nam HJ,Jeganathan KB,Kanakkanthara A,van Deursen JM

更新日期：2016-07-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. ...

journal_title：Nature cell biology

authors： Kamura T,Hara T,Matsumoto M,Ishida N,Okumura F,Hatakeyama S,Yoshida M,Nakayama K,Nakayama KI

更新日期：2004-12-01 00:00:00

abstract：:Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...

journal_title：Nature cell biology

authors： Zhuang X,Zhang H,Li X,Li X,Cong M,Peng F,Yu J,Zhang X,Yang Q,Hu G

更新日期：2017-10-01 00:00:00

abstract：:Focal adhesions are integrin-based multiprotein complexes, several micrometres in diameter, that mechanically link the extracellular matrix with the termini of actin bundles. The molecular diversity of focal adhesions and their role in cell migration and matrix sensing has been extensively studied, but their ultrastru...

journal_title：Nature cell biology

authors： Patla I,Volberg T,Elad N,Hirschfeld-Warneken V,Grashoff C,Fässler R,Spatz JP,Geiger B,Medalia O

更新日期：2010-09-01 00:00:00

abstract：:The migration of border cells during Drosophila melanogaster oogenesis is a simple and powerful system for studying invasive cell migration in vivo. Border cells are somatic cells that delaminate from the follicular epithelium of an egg chamber and invade the germ line cluster. They migrate between the nurse cells to ...

journal_title：Nature cell biology

authors： Fulga TA,Rørth P

更新日期：2002-09-01 00:00:00

abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

journal_title：Nature cell biology

authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

更新日期：2004-07-01 00:00:00

abstract：:Inhibitors of apoptosis (IAPs) inhibit caspases, thereby preventing proteolysis of apoptotic substrates. IAPs occlude the active sites of caspases to which they are bound and can function as ubiquitin ligases. IAPs are also reported to ubiquitinate themselves and caspases. Several proteins induce apoptosis, at least i...

journal_title：Nature cell biology

authors： Holley CL,Olson MR,Colón-Ramos DA,Kornbluth S

更新日期：2002-06-01 00:00:00

abstract：:Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA precursors and ribosomal proteins. These defects were associated with red...

journal_title：Nature cell biology

authors： Lessard F,Igelmann S,Trahan C,Huot G,Saint-Germain E,Mignacca L,Del Toro N,Lopes-Paciencia S,Le Calvé B,Montero M,Deschênes-Simard X,Bury M,Moiseeva O,Rowell MC,Zorca CE,Zenklusen D,Brakier-Gingras L,Bourdeau V,Oeffin

更新日期：2018-07-01 00:00:00

abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...

journal_title：Nature cell biology

authors： Petridou NI,Spiró Z,Heisenberg CP

更新日期：2017-05-31 00:00:00

abstract：:Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesin loading onto chro...

journal_title：Nature cell biology

authors： Nasmyth K

更新日期：2011-10-03 00:00:00