Abstract：
:Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Lefkowitz GK,Gleeson JGdoi
10.1038/ncb0909-1053subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1053-4issue
9eissn
1465-7392issn
1476-4679pii
ncb0909-1053journal_volume
11pub_type
评论,新闻abstract：:Chromosome loss or gain is associated with a large number of solid cancers, providing genomic plasticity and thus adaptability to cancer cells. Numerical centrosome abnormalities arising from centrosome over-duplication or failed cytokinesis are a recognized cause of aneuploidy. In higher eukaryotic cells, the centros...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1735
更新日期：2008-06-01 00:00:00
abstract：:Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these processes are important in many cells, few factors that regulate spindle placement are known. Previous work has shown that GPB-1, the Gbeta subunit of a hetero...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35060092
更新日期：2001-03-01 00:00:00
abstract：:Cadherin-containing cell-cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of c...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb2980
更新日期：2014-06-01 00:00:00
abstract：:In response to DNA damage, eukaryotic cells use a system of checkpoint controls to delay cell-cycle progression. Checkpoint delays provide time for repair of damaged DNA before its replication in S phase and before segregation of chromatids in M phase. The Cds1 (Chk2) tumour-suppressor protein has been implicated in c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35036406
更新日期：2000-10-01 00:00:00
abstract：:The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals. The ability of this network to coordinate and process a variety of inputs from different growth-factor receptors into specific biological responses is, however...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1543
更新日期：2007-03-01 00:00:00
abstract：:Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-019-0328-z
更新日期：2019-06-01 00:00:00
abstract：:Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced autophagy, nascent lysosomes are formed from autolysosomal membranes through an evolutionarily conserved cellular process, autophagic lysosome reformation (ALR), w...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2557
更新日期：2012-09-01 00:00:00
abstract：:Formation of a stable lamellipodium at the front of migrating cells requires localization of Rac activation to the leading edge. Restriction of alpha4 integrin phosphorylation to the leading edge limits the interaction of alpha4 with paxillin to the sides and rear of a migrating cell. The alpha4-paxillin complex inhib...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1234
更新日期：2005-04-01 00:00:00
abstract：:Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to ...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb0803-684
更新日期：2003-08-01 00:00:00
abstract：:Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35046598
更新日期：2000-12-01 00:00:00
abstract：:We describe a genome-wide gain-of-function screen for regulators of NF-kappaB, and identify Rap1 (Trf2IP), as an essential modulator of NF-kappaB-mediated pathways. NF-kappaB is induced by ectopic expression of Rap1, whereas its activity is inhibited by Rap1 depletion. In addition to localizing on telomeres, mammalian...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2080
更新日期：2010-08-01 00:00:00
abstract：:During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb434
更新日期：2007-09-01 00:00:00
abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3611
更新日期：2017-10-01 00:00:00
abstract：:When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225-dependent Rad9 phosphorylation, however, remains elusive. Here, we show that Thr 225-dependent Rad9 phosphorylation by...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1600
更新日期：2007-06-01 00:00:00
abstract：:Neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE are members of a family of proteins that use the Arp2/3 complex to stimulate actin assembly in actin-based motile processes. By entering into distinct macromolecular complexes, they act as convergent nodes of different signalling pathways. The role of WAVE in g...
journal_title：Nature cell biology
pub_type： 信件
doi：10.1038/ncb1304
更新日期：2005-10-01 00:00:00
abstract：:Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncoge...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb2657
更新日期：2013-02-01 00:00:00
abstract：:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3042
更新日期：2014-10-01 00:00:00
abstract：:The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb1104-1062
更新日期：2004-11-01 00:00:00
abstract：:TP53 (tumour protein 53) is one of the most frequently mutated genes in human cancer and its role during cellular transformation has been studied extensively. However, the homeostatic functions of p53 are less well understood. Here, we explore the molecular dependency network of TP53 through an RNAi-mediated synthetic...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2264
更新日期：2011-06-05 00:00:00
abstract：:Actin networks drive many essential cellular processes, including cell migration, cytokinesis and tissue morphogenesis. However, how cells organize and regulate dynamic actin networks that consist of long, unbranched actin filaments is only poorly understood. This study in mouse oocytes reveals that cells can use vesi...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2802
更新日期：2013-08-01 00:00:00
abstract：:The molecular requirements and morphology of migrating cells can vary depending on matrix geometry; therefore, predicting the optimal migration strategy or the effect of experimental perturbation is difficult. We present a model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contr...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2775
更新日期：2013-07-01 00:00:00
abstract：:To generate the various tissues and organs that build up the adult body, plants and animals require organized formative cell divisions and correct cell specification. In plants, these processes are controlled mainly by phytohormones and transcriptional networks. Recently, ligand-receptor-like kinase signalling pathway...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb1009-1166
更新日期：2009-10-01 00:00:00
abstract：:The remarkable stability of gene expression in somatic cells is exemplified by the way memory of an active gene state is retained when an endoderm cell nucleus is transplanted to an enucleated egg. Here we analyse the mechanism of a similar example of epigenetic memory. We find that memory can persist through 24 cell ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1674
更新日期：2008-01-01 00:00:00
abstract：:The migration of border cells during Drosophila melanogaster oogenesis is a simple and powerful system for studying invasive cell migration in vivo. Border cells are somatic cells that delaminate from the follicular epithelium of an egg chamber and invade the germ line cluster. They migrate between the nurse cells to ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb848
更新日期：2002-09-01 00:00:00
abstract：:Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative process are actively sought after. Here, we show that reduced cytosolic protein synthesis is a robust cellular strategy that suppr...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1769
更新日期：2008-09-01 00:00:00
abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35023547
更新日期：2000-09-01 00:00:00
abstract：:Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35070050
更新日期：2001-04-01 00:00:00
abstract：:YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3111
更新日期：2015-04-01 00:00:00
abstract：:Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory element...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3591
更新日期：2017-08-31 00:00:00
abstract：:Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show that GALA induces th...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-020-00590-w
更新日期：2020-11-01 00:00:00
