Abstract:
:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell populations like stem cells. Techniques for single-cell analyses, ideally allowing non-invasive quantification of molecular dynamics and cellular behaviour over time, are required for studying stem cells. Here, we review the development and application of these techniques to stem cell research.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Hoppe PS,Coutu DL,Schroeder Tdoi
10.1038/ncb3042subject
Has Abstractpub_date
2014-10-01 00:00:00pages
919-27issue
10eissn
1465-7392issn
1476-4679pii
ncb3042journal_volume
16pub_type
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更新日期:2011-01-01 00:00:00
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