Abstract:
:Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Blanpain Cdoi
10.1038/ncb2657subject
Has Abstractpub_date
2013-02-01 00:00:00pages
126-34issue
2eissn
1465-7392issn
1476-4679pii
ncb2657journal_volume
15pub_type
杂志文章,评审abstract::Cell division is fundamental for all organisms. Here we report a genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division. We have used a library of endoribonuclease-prepared short interfering RNAs for gene silencing and have used DNA content ana...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1659
更新日期:2007-12-01 00:00:00
abstract::Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1275
更新日期:2005-07-01 00:00:00
abstract::Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to directly examine the f...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3450
更新日期:2017-01-01 00:00:00
abstract::When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225-dependent Rad9 phosphorylation, however, remains elusive. Here, we show that Thr 225-dependent Rad9 phosphorylation by...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1600
更新日期:2007-06-01 00:00:00
abstract::Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35017080
更新日期:2000-07-01 00:00:00
abstract::Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3250
更新日期:2015-11-01 00:00:00
abstract::Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or gamma-irradiation. The preRC assembles on replication origins at the end of mitosis and durin...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1061
更新日期:2003-11-01 00:00:00
abstract::Chromosome loss or gain is associated with a large number of solid cancers, providing genomic plasticity and thus adaptability to cancer cells. Numerical centrosome abnormalities arising from centrosome over-duplication or failed cytokinesis are a recognized cause of aneuploidy. In higher eukaryotic cells, the centros...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1735
更新日期:2008-06-01 00:00:00
abstract::The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3075
更新日期:2015-01-01 00:00:00
abstract::Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and tran...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3498
更新日期:2017-04-01 00:00:00
abstract::Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/35046510
更新日期:2000-12-01 00:00:00
abstract::The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb1104-1062
更新日期:2004-11-01 00:00:00
abstract::In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...
journal_title:Nature cell biology
pub_type: 已发布勘误
doi:10.1038/s41556-018-0166-4
更新日期:2018-10-01 00:00:00
abstract::Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromoso...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2050
更新日期:2010-05-01 00:00:00
abstract::Chromophore-assisted laser inactivation (CALI) is a light-mediated technique used to selectively inactivate proteins within cells. Here, we demonstrate that GFP can be used as a CALI reagent to locally inactivate proteins in living cells. We show that focused laser irradiation of EGFP-alpha-actinin expressed in Swiss ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb772
更新日期:2002-04-01 00:00:00
abstract::The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb3524
更新日期:2017-05-31 00:00:00
abstract::Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic cell spaces to control cellular morphogenesis is unclear. Through a fam...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/s41556-020-0488-x
更新日期:2020-04-01 00:00:00
abstract::Phosphoinositide 3-kinase (PI(3)K) is a unique enzyme characterized by both lipid and protein kinase activities. Here, we demonstrate a requirement for the protein kinase activity of PI(3)K in agonist-dependent beta-adrenergic receptor (betaAR) internalization. Using PI(3)K mutants with either protein or lipid phospho...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1278
更新日期:2005-08-01 00:00:00
abstract::Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3070
更新日期:2014-12-01 00:00:00
abstract::Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb3444
更新日期:2017-01-01 00:00:00
abstract::Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2340
更新日期:2011-09-25 00:00:00
abstract::Despite the presence of mutations in APC or beta-catenin, which are believed to activate the Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity when beta-catenin localization is analysed, indicating a more complex regulation of Wnt signalling. We explored this heterogeneity with...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2048
更新日期:2010-05-01 00:00:00
abstract::Localization and activation of heterotrimeric G proteins have a crucial role during asymmetric cell division. The asymmetric division of the Drosophila sensory precursor cell (pl) is polarized along the antero-posterior axis by Frizzled signalling and, during this division, activation of Galphai depends on Partner of ...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1319
更新日期:2005-11-01 00:00:00
abstract::TP53 (tumour protein 53) is one of the most frequently mutated genes in human cancer and its role during cellular transformation has been studied extensively. However, the homeostatic functions of p53 are less well understood. Here, we explore the molecular dependency network of TP53 through an RNAi-mediated synthetic...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2264
更新日期:2011-06-05 00:00:00
abstract::Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...
journal_title:Nature cell biology
pub_type: 社论
doi:10.1038/ncb1109-1273a
更新日期:2009-11-01 00:00:00
abstract::Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic mark that specifies centromere identity. Here we identify the essential centromere...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb1899
更新日期:2009-07-01 00:00:00
abstract::Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating bot...
journal_title:Nature cell biology
pub_type: 评论,杂志文章
doi:10.1038/ncb3086
更新日期:2015-01-01 00:00:00
abstract::Mammalian and most fungal infectious proteins (also known as prions) are self-propagating amyloid, a filamentous beta-sheet structure. A prion domain determines the infectious properties of a protein by forming the core of the amyloid. We compare the properties of known prion domains and their interactions with the re...
journal_title:Nature cell biology
pub_type: 杂志文章,评审
doi:10.1038/ncb1105-1039
更新日期:2005-11-01 00:00:00
abstract::Junior researchers are encouraged to gain experience abroad, and for senior scientists, sabbaticals remain popular. France has taken the next step in fostering international exchange, by supporting long-term collaborations with foreign laboratories and by creating research units abroad. ...
journal_title:Nature cell biology
pub_type: 社论
doi:10.1038/ncb0607-613
更新日期:2007-06-01 00:00:00
abstract::Focal adhesions are integrin-based multiprotein complexes, several micrometres in diameter, that mechanically link the extracellular matrix with the termini of actin bundles. The molecular diversity of focal adhesions and their role in cell migration and matrix sensing has been extensively studied, but their ultrastru...
journal_title:Nature cell biology
pub_type: 杂志文章
doi:10.1038/ncb2095
更新日期:2010-09-01 00:00:00