Adherens junction treadmilling during collective migration.

Abstract:

:Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of adjacent leading cells. The treadmilling is driven by an actin-dependent rearward movement of AJs and is supported by the polarized recycling of N-cadherin. N-cadherin is mainly internalized at the cell rear and then recycled to the leading edge where it accumulates before being incorporated into forming AJs at the front of lateral cell-cell contacts. The polarized dynamics of AJs is controlled by a front-to-rear gradient of p120-catenin phosphorylation, which regulates polarized trafficking of N-cadherin. Perturbation of the GSK3-dependent phosphorylation of p120-catenin impacts on the stability of AJs, and the polarity and speed of leading cells during collective migration.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Peglion F,Llense F,Etienne-Manneville S

doi

10.1038/ncb2985

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

639-51

issue

7

eissn

1465-7392

issn

1476-4679

pii

ncb2985

journal_volume

16

pub_type

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