Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

abstract：:Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced autophagy, nascent lysosomes are formed from autolysosomal membranes through an evolutionarily conserved cellular process, autophagic lysosome reformation (ALR), w...

journal_title：Nature cell biology

authors： Rong Y,Liu M,Ma L,Du W,Zhang H,Tian Y,Cao Z,Li Y,Ren H,Zhang C,Li L,Chen S,Xi J,Yu L

更新日期：2012-09-01 00:00:00

abstract：:Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...

journal_title：Nature cell biology

authors： Hu S,Dasbiswas K,Guo Z,Tee YH,Thiagarajan V,Hersen P,Chew TL,Safran SA,Zaidel-Bar R,Bershadsky AD

更新日期：2017-02-01 00:00:00

abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...

journal_title：Nature cell biology

authors： Yang JS,Gad H,Lee SY,Mironov A,Zhang L,Beznoussenko GV,Valente C,Turacchio G,Bonsra AN,Du G,Baldanzi G,Graziani A,Bourgoin S,Frohman MA,Luini A,Hsu VW

更新日期：2008-10-01 00:00:00

abstract：:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell c...

journal_title：Nature cell biology

authors： Hidalgo-Carcedo C,Hooper S,Chaudhry SI,Williamson P,Harrington K,Leitinger B,Sahai E

更新日期：2011-01-01 00:00:00

abstract：:The vertebrate neural crest arises at the border of the neural plate during early stages of nervous system development; however, little is known about the molecular mechanisms underlying neural crest formation. Here we identify a secreted protein, Noelin-1, which has the ability to prolong neural crest production. Noe...

journal_title：Nature cell biology

authors： Barembaum M,Moreno TA,LaBonne C,Sechrist J,Bronner-Fraser M

更新日期：2000-04-01 00:00:00

abstract：:The molecular mechanisms underlying the formation of carriers trafficking from the Golgi complex to the cell surface are still ill-defined; nevertheless, the involvement of a lipid-based machinery is well established. This includes phosphatidylinositol 4-phosphate (PtdIns(4)P), the precursor for phosphatidylinositol 4...

journal_title：Nature cell biology

authors： Godi A,Di Campli A,Konstantakopoulos A,Di Tullio G,Alessi DR,Kular GS,Daniele T,Marra P,Lucocq JM,De Matteis MA

更新日期：2004-05-01 00:00:00

abstract：:The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show that Ran-GTP stimulates microtubule assembly by increasing the rescue frequency of microtubules three- to eightf...

journal_title：Nature cell biology

authors： Wilde A,Lizarraga SB,Zhang L,Wiese C,Gliksman NR,Walczak CE,Zheng Y

更新日期：2001-03-01 00:00:00

abstract：:Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...

journal_title：Nature cell biology

authors： Römisch K,Matheson T

更新日期：2003-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...

journal_title：Nature cell biology

authors： Mavrakis KJ,Wolfe AL,Oricchio E,Palomero T,de Keersmaecker K,McJunkin K,Zuber J,James T,Khan AA,Leslie CS,Parker JS,Paddison PJ,Tam W,Ferrando A,Wendel HG

更新日期：2010-04-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. ...

journal_title：Nature cell biology

authors： Kamura T,Hara T,Matsumoto M,Ishida N,Okumura F,Hatakeyama S,Yoshida M,Nakayama K,Nakayama KI

更新日期：2004-12-01 00:00:00

abstract：:During the development of multicellular organisms, concerted actions of molecular signalling networks determine whether cells undergo proliferation, differentiation, death or ageing. Here we show that genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic l...

journal_title：Nature cell biology

authors： Wada T,Joza N,Cheng HY,Sasaki T,Kozieradzki I,Bachmaier K,Katada T,Schreiber M,Wagner EF,Nishina H,Penninger JM

更新日期：2004-03-01 00:00:00

abstract：:Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...

journal_title：Nature cell biology

authors： Hatch EM

更新日期：2016-12-23 00:00:00

abstract：:The formation of axon trajectories requires integration of local adhesive interactions with directional information from attractive and repulsive cues. Here, we show that these two types of information are functionally integrated; activation of the transmembrane receptor Roundabout (Robo) by its ligand, the secreted r...

journal_title：Nature cell biology

authors： Rhee J,Mahfooz NS,Arregui C,Lilien J,Balsamo J,VanBerkum MF

更新日期：2002-10-01 00:00:00

abstract：:Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...

journal_title：Nature cell biology

authors： Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV

更新日期：2015-02-01 00:00:00

abstract：:Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...

journal_title：Nature cell biology

authors： Alanko J,Mai A,Jacquemet G,Schauer K,Kaukonen R,Saari M,Goud B,Ivaska J

更新日期：2015-11-01 00:00:00

abstract：:Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of...

journal_title：Nature cell biology

authors： Peglion F,Llense F,Etienne-Manneville S

更新日期：2014-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-beta signals through its Type II and Type I receptors (TbetaRII and TbetaRI) causing phosphorylation of Smad proteins. TGF-beta...

journal_title：Nature cell biology

authors： Sorrentino A,Thakur N,Grimsby S,Marcusson A,von Bulow V,Schuster N,Zhang S,Heldin CH,Landström M

更新日期：2008-10-01 00:00:00

abstract：:Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. Here, we discovered an unexpected role for yeast dynein light chain (Dyn2) in the NPC. Dyn2 is a previously undescribed nucleoporin that functions as molecular glue to dimerize and stabilize the Nup82-Nsp1-Nup159...

journal_title：Nature cell biology

authors： Stelter P,Kunze R,Flemming D,Höpfner D,Diepholz M,Philippsen P,Böttcher B,Hurt E

更新日期：2007-07-01 00:00:00

abstract：:Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) proteins. The molecular...

journal_title：Nature cell biology

authors： Abreu JG,Ketpura NI,Reversade B,De Robertis EM

更新日期：2002-08-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...

journal_title：Nature cell biology

authors： Floros VI,Pyle A,Dietmann S,Wei W,Tang WCW,Irie N,Payne B,Capalbo A,Noli L,Coxhead J,Hudson G,Crosier M,Strahl H,Khalaf Y,Saitou M,Ilic D,Surani MA,Chinnery PF

更新日期：2018-02-01 00:00:00

abstract：:Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glyc...

journal_title：Nature cell biology

authors： Barnes JM,Kaushik S,Bainer RO,Sa JK,Woods EC,Kai F,Przybyla L,Lee M,Lee HW,Tung JC,Maller O,Barrett AS,Lu KV,Lakins JN,Hansen KC,Obernier K,Alvarez-Buylla A,Bergers G,Phillips JJ,Nam DH,Bertozzi CR,Weaver VM

更新日期：2018-10-01 00:00:00

abstract：:The Drosophila fruitless (fru) gene product Fru has been postulated to be a neural sex-determination factor that directs the development of at least two male-specific characteristics, namely courtship behaviour and formation of the muscle of Lawrence (MOL). The fru gene encodes a putative transcription factor with a B...

journal_title：Nature cell biology

authors： Usui-Aoki K,Ito H,Ui-Tei K,Takahashi K,Lukacsovich T,Awano W,Nakata H,Piao ZF,Nilsson EE,Tomida J,Yamamoto D

更新日期：2000-08-01 00:00:00

abstract：:Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that tumour-secreted DKK1 is a serological marker of breast cancer metastasis organotropism and inhibits lung metastasis. DKK1 suppresses PTGS2-induced macrophage and ne...

journal_title：Nature cell biology

authors： Zhuang X,Zhang H,Li X,Li X,Cong M,Peng F,Yu J,Zhang X,Yang Q,Hu G

更新日期：2017-10-01 00:00:00

abstract：:MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides in length. Increasing evidence implicates miRs in myocardial disease processes. Here we show that miR-199b is a direct calcineurin/NFAT target gene that increases in expression in mouse and human heart failure, and targets the nuc...

journal_title：Nature cell biology

authors： da Costa Martins PA,Salic K,Gladka MM,Armand AS,Leptidis S,el Azzouzi H,Hansen A,Coenen-de Roo CJ,Bierhuizen MF,van der Nagel R,van Kuik J,de Weger R,de Bruin A,Condorelli G,Arbones ML,Eschenhagen T,De Windt LJ

更新日期：2010-12-01 00:00:00

abstract：:In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...

journal_title：Nature cell biology

authors： Park S,Szumlanski AL,Gu F,Guo F,Nielsen E

更新日期：2011-07-17 00:00:00

abstract：:YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...

journal_title：Nature cell biology

authors： Mo JS,Meng Z,Kim YC,Park HW,Hansen CG,Kim S,Lim DS,Guan KL

更新日期：2015-04-01 00:00:00

abstract：:Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...

journal_title：Nature cell biology

authors： Tsukamoto T,Hashiguchi N,Janicki SM,Tumbar T,Belmont AS,Spector DL

更新日期：2000-12-01 00:00:00

abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

journal_title：Nature cell biology

authors： Aravamudhan P,Goldfarb AA,Joglekar AP

更新日期：2015-07-01 00:00:00

abstract：:Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen. This action of NO has both physiological and pathophysiological consequences. Here we report that endogenously generated NO, which disrupts the respiratory chain, may cause ...

journal_title：Nature cell biology

authors： Xu W,Liu L,Charles IG,Moncada S

更新日期：2004-11-01 00:00:00

abstract：:To study the role of the BH3 domain in mediating pro-apoptotic and anti-apoptotic activities of Bcl-2 family members, we identified a series of novel small molecules (BH3Is) that inhibit the binding of the Bak BH3 peptide to Bcl-xL. NMR analyses revealed that BH3Is target the BH3-binding pocket of Bcl-xL. Inhibitors s...

journal_title：Nature cell biology

authors： Degterev A,Lugovskoy A,Cardone M,Mulley B,Wagner G,Mitchison T,Yuan J

更新日期：2001-02-01 00:00:00