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Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.

Abstract：

:Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) proteins. The molecular mechanism by which CTGF or other CCN proteins regulate cell signalling is not known. CTGF contains a cysteine-rich domain (CR) similar to those found in chordin and other secreted proteins, which in some cases have been reported to function as bone morphogenetic protein (BMP) and TGF-beta binding domains. Here we show that CTGF directly binds BMP4 and TGF-beta 1 through its CR domain. CTGF can antagonize BMP4 activity by preventing its binding to BMP receptors and has the opposite effect, enhancement of receptor binding, on TGF-beta 1. These results show that CTGF inhibits BMP and activates TGF-beta signals by direct binding in the extracellular space.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Abreu JG,Ketpura NI,Reversade B,De Robertis EM

doi

10.1038/ncb826

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

599-604

issue

8

eissn

1465-7392

issn

1476-4679

pii

ncb826

journal_volume

4

pub_type

杂志文章

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