当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

Abstract：

:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell contacts, migrating cells lose cohesion. We provide a molecular mechanism for this downregulation. Depletion of discoidin domain receptor 1 (DDR1) blocks collective cancer-cell invasion in a range of two-dimensional, three-dimensional and 'organotypic' models. DDR1 coordinates the Par3/Par6 cell-polarity complex through its carboxy terminus, binding PDZ domains in Par3 and Par6. The DDR1-Par3/Par6 complex controls the localization of RhoE to cell-cell contacts, where it antagonizes ROCK-driven actomyosin contractility. Depletion of DDR1, Par3, Par6 or RhoE leads to increased actomyosin contactility at cell-cell contacts, a loss of cell-cell cohesion and defective collective cell invasion.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Hidalgo-Carcedo C,Hooper S,Chaudhry SI,Williamson P,Harrington K,Leitinger B,Sahai E

doi

10.1038/ncb2133

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

49-58

issue

1

eissn

1465-7392

issn

1476-4679

pii

ncb2133

journal_volume

13

pub_type

杂志文章

相关文献

NATURE CELL BIOLOGY文献大全
  • NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.

    abstract：:NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-as...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb990

    authors： Sans N,Prybylowski K,Petralia RS,Chang K,Wang YX,Racca C,Vicini S,Wenthold RJ

    更新日期：2003-06-01 00:00:00

  • Prion: disease or relief?

    abstract：:The self-perpetuating amyloid isoform, or prion, of the yeast translation termination factor eRF3 modulates programmed translational frameshifting that controls a regulatory circuit determining the polyamine levels in a yeast cell. But it is still unclear whether this effect is adaptive or pathological. ...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/ncb0908-1019

    authors： Chernoff YO

    更新日期：2008-09-01 00:00:00

  • The Ets transcription factor GABP is required for cell-cycle progression.

    abstract：:The transition from cellular quiescence (G0) into S phase is regulated by the mitogenic-activation of D-type cyclins and cyclin-dependent kinases (Cdks), the sequestration of the Cdk inhibitors (CDKIs), p21 and p27, and the hyperphosphorylation of Rb with release of E2F transcription factors. However, fibroblasts that...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1548

    authors： Yang ZF,Mott S,Rosmarin AG

    更新日期：2007-03-01 00:00:00

  • Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.

    abstract：:Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) involves a marked reorganization of chromatin. To identify post-translational histone modifications that change in global abundance during this process, we have applied a quantitative mass-spectrometry-based approach. We found that iPSCs, compa...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2768

    authors： Sridharan R,Gonzales-Cope M,Chronis C,Bonora G,McKee R,Huang C,Patel S,Lopez D,Mishra N,Pellegrini M,Carey M,Garcia BA,Plath K

    更新日期：2013-07-01 00:00:00

  • Skp2: caught in the Akt.

    abstract：:To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphoryla...

    journal_title：Nature cell biology

    pub_type： 评论,新闻

    doi：10.1038/ncb0409-377

    authors： Ecker K,Hengst L

    更新日期：2009-04-01 00:00:00

  • Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia.

    abstract：:Aberrant activation of beta-catenin promotes cell proliferation and initiates colorectal tumorigenesis. However, the expansion of tumours and the inadequacy of their local vasculature results in areas of hypoxia where cell growth is typically constrained. Here, we report a novel diversion in beta-catenin signalling tr...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1534

    authors： Kaidi A,Williams AC,Paraskeva C

    更新日期：2007-02-01 00:00:00

  • Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

    abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3573

    authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

    更新日期：2017-08-01 00:00:00

  • Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

    abstract：:The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Ex...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0040-4

    authors： Zhang H,Freitas D,Kim HS,Fabijanic K,Li Z,Chen H,Mark MT,Molina H,Martin AB,Bojmar L,Fang J,Rampersaud S,Hoshino A,Matei I,Kenific CM,Nakajima M,Mutvei AP,Sansone P,Buehring W,Wang H,Jimenez JP,Cohen-Gould L,P

    更新日期：2018-03-01 00:00:00

  • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

    abstract：:Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in sig...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb884

    authors： Fernandez-Capetillo O,Chen HT,Celeste A,Ward I,Romanienko PJ,Morales JC,Naka K,Xia Z,Camerini-Otero RD,Motoyama N,Carpenter PB,Bonner WM,Chen J,Nussenzweig A

    更新日期：2002-12-01 00:00:00

  • Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.

    abstract：:Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3444

    authors： Henninger J,Santoso B,Hans S,Durand E,Moore J,Mosimann C,Brand M,Traver D,Zon L

    更新日期：2017-01-01 00:00:00

  • A model for transmission of the H3K27me3 epigenetic mark.

    abstract：:Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1787

    authors： Hansen KH,Bracken AP,Pasini D,Dietrich N,Gehani SS,Monrad A,Rappsilber J,Lerdrup M,Helin K

    更新日期：2008-11-01 00:00:00

  • Homologue recognition during meiosis is associated with a change in chromatin conformation.

    abstract：:During meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other. Here we show, by comparing the ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1168

    authors： Prieto P,Shaw P,Moore G

    更新日期：2004-09-01 00:00:00

  • The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.

    abstract：:The spindle checkpoint ensures accurate chromosome segregation by delaying cell-cycle progression until all sister kinetochores capture microtubules from opposite poles and come under tension (for reviews, see refs 1, 2). Although the checkpoint is activated by either the lack of kinetochore-microtubule attachments or...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1341

    authors： Pinsky BA,Kung C,Shokat KM,Biggins S

    更新日期：2006-01-01 00:00:00

  • Extracellular serine controls epidermal stem cell fate and tumour initiation.

    abstract：:Tissue stem cells are the cell of origin for many malignancies. Metabolites regulate the balance between self-renewal and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose stem cells towards transformation remains unknown. Here, we address this question in epidermal stem ce...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-0525-9

    authors： Baksh SC,Todorova PK,Gur-Cohen S,Hurwitz B,Ge Y,Novak JSS,Tierney MT,Dela Cruz-Racelis J,Fuchs E,Finley LWS

    更新日期：2020-07-01 00:00:00

  • Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice.

    abstract：:When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225-dependent Rad9 phosphorylation, however, remains elusive. Here, we show that Thr 225-dependent Rad9 phosphorylation by...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1600

    authors： Kai M,Furuya K,Paderi F,Carr AM,Wang TS

    更新日期：2007-06-01 00:00:00

  • Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins.

    abstract：:Chromophore-assisted laser inactivation (CALI) is a light-mediated technique used to selectively inactivate proteins within cells. Here, we demonstrate that GFP can be used as a CALI reagent to locally inactivate proteins in living cells. We show that focused laser irradiation of EGFP-alpha-actinin expressed in Swiss ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb772

    authors： Rajfur Z,Roy P,Otey C,Romer L,Jacobson K

    更新日期：2002-04-01 00:00:00

  • Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion.

    abstract：:The formation of axon trajectories requires integration of local adhesive interactions with directional information from attractive and repulsive cues. Here, we show that these two types of information are functionally integrated; activation of the transmembrane receptor Roundabout (Robo) by its ligand, the secreted r...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb858

    authors： Rhee J,Mahfooz NS,Arregui C,Lilien J,Balsamo J,VanBerkum MF

    更新日期：2002-10-01 00:00:00

  • A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.

    abstract：:Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35017080

    authors： Moreau V,Frischknecht F,Reckmann I,Vincentelli R,Rabut G,Stewart D,Way M

    更新日期：2000-07-01 00:00:00

  • EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

    abstract：:The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a ke...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1750

    authors： Kolev V,Mandinova A,Guinea-Viniegra J,Hu B,Lefort K,Lambertini C,Neel V,Dummer R,Wagner EF,Dotto GP

    更新日期：2008-08-01 00:00:00

  • Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation.

    abstract：:The initial differential treatment of the two X chromosomes during X-chromosome inactivation is controlled by the X-inactivation centre (Xic). This locus determines how many X chromosomes are present in a cell ('counting') and which X chromosome will be inactivated in female cells ('choice'). Critical control sequence...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1365

    authors： Bacher CP,Guggiari M,Brors B,Augui S,Clerc P,Avner P,Eils R,Heard E

    更新日期：2006-03-01 00:00:00

  • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

    abstract：:Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA repair mechanisms and degradation. Mammalian telomeric chromatin is enriched for the constitutive heterochromatin marks H3K9me3, H4K20me3 and HP1 (refs 2, 3, 4, 5, ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1685

    authors： Schoeftner S,Blasco MA

    更新日期：2008-02-01 00:00:00

  • Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

    abstract：:During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and daughter centriole. This linker is disassembled at the onset of mitosis in a process known as centrosome disjunction, thereby facilitating centrosome separation and bipolar spindle formation. Th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2120

    authors： Mardin BR,Lange C,Baxter JE,Hardy T,Scholz SR,Fry AM,Schiebel E

    更新日期：2010-12-01 00:00:00

  • Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.

    abstract：:Over their lifetime, long-term haematopoietic stem cells (HSC) are exposed to a variety of stress conditions that they must endure. Many stresses, such as infection/inflammation, reactive oxygen species, nutritional deprivation and hypoxia, activate unfolded protein response signalling, which induces either adaptive c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0285-6

    authors： Liu L,Zhao M,Jin X,Ney G,Yang KB,Peng F,Cao J,Iwawaki T,Del Valle J,Chen X,Li Q

    更新日期：2019-03-01 00:00:00

  • Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

    abstract：:Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3534

    authors： Jin Y,Muhl L,Burmakin M,Wang Y,Duchez AC,Betsholtz C,Arthur HM,Jakobsson L

    更新日期：2017-06-01 00:00:00

  • The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.

    abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3179

    authors： Aravamudhan P,Goldfarb AA,Joglekar AP

    更新日期：2015-07-01 00:00:00

  • Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions.

    abstract：:The molecular requirements and morphology of migrating cells can vary depending on matrix geometry; therefore, predicting the optimal migration strategy or the effect of experimental perturbation is difficult. We present a model of cell motility that encompasses actin-polymerization-based protrusions, actomyosin contr...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2775

    authors： Tozluoğlu M,Tournier AL,Jenkins RP,Hooper S,Bates PA,Sahai E

    更新日期：2013-07-01 00:00:00

  • Single-cell technologies sharpen up mammalian stem cell research.

    abstract：:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb3042

    authors： Hoppe PS,Coutu DL,Schroeder T

    更新日期：2014-10-01 00:00:00

  • Visualization of gene activity in living cells.

    abstract：:Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35046510

    authors： Tsukamoto T,Hashiguchi N,Janicki SM,Tumbar T,Belmont AS,Spector DL

    更新日期：2000-12-01 00:00:00

  • Publisher Correction: Single-cell multi-omics sequencing of human early embryos.

    abstract：:In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...

    journal_title：Nature cell biology

    pub_type： 已发布勘误

    doi：10.1038/s41556-018-0166-4

    authors： Li L,Guo F,Gao Y,Ren Y,Yuan P,Yan L,Li R,Lian Y,Li J,Hu B,Gao J,Wen L,Tang F,Qiao J

    更新日期：2018-10-01 00:00:00

  • Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

    abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35087061

    authors： Farassati F,Yang AD,Lee PW

    更新日期：2001-08-01 00:00:00