Extracellular serine controls epidermal stem cell fate and tumour initiation.

abstract：:Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. ...

journal_title：Nature cell biology

authors： Yahara Y,Barrientos T,Tang YJ,Puviindran V,Nadesan P,Zhang H,Gibson JR,Gregory SG,Diao Y,Xiang Y,Qadri YJ,Souma T,Shinohara ML,Alman BA

更新日期：2020-01-01 00:00:00

abstract：:PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P(2)) and phosphatidylinositol-3...

journal_title：Nature cell biology

authors： Kanai F,Liu H,Field SJ,Akbary H,Matsuo T,Brown GE,Cantley LC,Yaffe MB

更新日期：2001-07-01 00:00:00

abstract：:The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...

journal_title：Nature cell biology

authors： Pan Z,Yang D,Nagaraj RY,Nosek TA,Nishi M,Takeshima H,Cheng H,Ma J

更新日期：2002-05-01 00:00:00

abstract：:Analysis of the mechanisms underlying cell fates requires the molecular quantification of cellular features. Classical techniques use population average readouts at single time points. However, these approaches mask cellular heterogeneity and dynamics and are limited for studying rare and heterogeneous cell population...

journal_title：Nature cell biology

authors： Hoppe PS,Coutu DL,Schroeder T

更新日期：2014-10-01 00:00:00

abstract：:Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance; however, its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. However, β-catenin has additional roles at the plasma membra...

journal_title：Nature cell biology

authors： Lyashenko N,Winter M,Migliorini D,Biechele T,Moon RT,Hartmann C

更新日期：2011-06-19 00:00:00

abstract：:The Ndc80 complex (Ndc80, Nuf2, Spc24 and Spc25) is a highly conserved kinetochore protein essential for end-on anchorage to spindle microtubule plus ends and for force generation coupled to plus-end polymerization and depolymerization. Spc24/Spc25 at one end of the Ndc80 complex binds the kinetochore. The N-terminal ...

journal_title：Nature cell biology

authors： Suzuki A,Badger BL,Haase J,Ohashi T,Erickson HP,Salmon ED,Bloom K

更新日期：2016-04-01 00:00:00

abstract：:Cell-cell adhesion mediated by specific cell-surface molecules is essential for multicellular development. Here we quantify de-adhesion forces at the resolution of individual cell-adhesion molecules, by controlling the interactions between single cells and combining single-molecule force spectroscopy with genetic mani...

journal_title：Nature cell biology

authors： Benoit M,Gabriel D,Gerisch G,Gaub HE

更新日期：2000-06-01 00:00:00

abstract：:The anaphase-promoting complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin. Lys 48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradation of cyclin B...

journal_title：Nature cell biology

authors： Dimova NV,Hathaway NA,Lee BH,Kirkpatrick DS,Berkowitz ML,Gygi SP,Finley D,King RW

更新日期：2012-01-29 00:00:00

abstract：:Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...

journal_title：Nature cell biology

authors： Kaminski MM,Tosic J,Kresbach C,Engel H,Klockenbusch J,Müller AL,Pichler R,Grahammer F,Kretz O,Huber TB,Walz G,Arnold SJ,Lienkamp SS

更新日期：2016-12-01 00:00:00

abstract：:Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes sy...

journal_title：Nature cell biology

authors： Zhou BO,Yu H,Yue R,Zhao Z,Rios JJ,Naveiras O,Morrison SJ

更新日期：2017-08-01 00:00:00

abstract：:Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches. The p...

journal_title：Nature cell biology

authors： Youn CK,Cho HJ,Kim SH,Kim HB,Kim MH,Chang IY,Lee JS,Chung MH,Hahm KS,You HJ

更新日期：2005-02-01 00:00:00

abstract：:Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that slide misaligned chromoso...

journal_title：Nature cell biology

authors： Barisic M,Aguiar P,Geley S,Maiato H

更新日期：2014-12-01 00:00:00

abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

journal_title：Nature cell biology

authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

更新日期：2019-09-01 00:00:00

abstract：:During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify lineage and differentiation status. Among these factors, the transforming growth factor (TGF)-beta family is imp...

journal_title：Nature cell biology

authors： Derynck R,Akhurst RJ

更新日期：2007-09-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature cell biology

authors： Huang Y,Zucker B,Zhang S,Elias S,Zhu Y,Chen H,Ding T,Li Y,Sun Y,Lou J,Kozlov MM,Yu L

更新日期：2019-10-01 00:00:00

abstract：:Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in sig...

journal_title：Nature cell biology

authors： Fernandez-Capetillo O,Chen HT,Celeste A,Ward I,Romanienko PJ,Morales JC,Naka K,Xia Z,Camerini-Otero RD,Motoyama N,Carpenter PB,Bonner WM,Chen J,Nussenzweig A

更新日期：2002-12-01 00:00:00

abstract：:Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin's directionality and...

journal_title：Nature cell biology

authors： Endow SA

更新日期：1999-10-01 00:00:00

abstract：:Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remode...

journal_title：Nature cell biology

authors： Anitei M,Stange C,Parshina I,Baust T,Schenck A,Raposo G,Kirchhausen T,Hoflack B

更新日期：2010-04-01 00:00:00

abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...

journal_title：Nature cell biology

authors： Petridou NI,Spiró Z,Heisenberg CP

更新日期：2017-05-31 00:00:00

abstract：:Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...

journal_title：Nature cell biology

authors： Coppé JP,Mori M,Pan B,Yau C,Wolf DM,Ruiz-Saenz A,Brunen D,Prahallad A,Cornelissen-Steijger P,Kemper K,Posch C,Wang C,Dreyer CA,Krijgsman O,Lee PRE,Chen Z,Peeper DS,Moasser MM,Bernards R,van 't Veer LJ

更新日期：2019-06-01 00:00:00

abstract：:The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (N...

journal_title：Nature cell biology

authors： Zheng W,Umitsu M,Jagan I,Tran CW,Ishiyama N,BeGora M,Araki K,Ohashi PS,Ikura M,Muthuswamy SK

更新日期：2016-11-01 00:00:00

abstract：:Proteins containing ubiquitin-binding domains (UBDs) interact with ubiquitinated targets and regulate diverse biological processes, including endocytosis, signal transduction, transcription and DNA repair. Many of the UBD-containing proteins are also themselves monoubiquitinated, but the functional role and the mechan...

journal_title：Nature cell biology

authors： Hoeller D,Crosetto N,Blagoev B,Raiborg C,Tikkanen R,Wagner S,Kowanetz K,Breitling R,Mann M,Stenmark H,Dikic I

更新日期：2006-02-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotency. Here, we re...

journal_title：Nature cell biology

authors： Giulitti S,Pellegrini M,Zorzan I,Martini P,Gagliano O,Mutarelli M,Ziller MJ,Cacchiarelli D,Romualdi C,Elvassore N,Martello G

更新日期：2019-02-01 00:00:00

abstract：:Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear. Using single-molecule imaging, we directly observe that the microtubule latt...

journal_title：Nature cell biology

authors： Tan R,Lam AJ,Tan T,Han J,Nowakowski DW,Vershinin M,Simó S,Ori-McKenney KM,McKenney RJ

更新日期：2019-09-01 00:00:00

abstract：:Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which drives a TGF-β-rich s...

journal_title：Nature cell biology

authors： Hoare M,Ito Y,Kang TW,Weekes MP,Matheson NJ,Patten DA,Shetty S,Parry AJ,Menon S,Salama R,Antrobus R,Tomimatsu K,Howat W,Lehner PJ,Zender L,Narita M

更新日期：2016-09-01 00:00:00

abstract：:Recent theoretical analysis of a model lattice of interacting transmembrane receptor proteins has indicated that such clustering in the membrane could provide a novel mechanism for regulating receptor signalling in cells. It has been calculated that cooperative interactions between receptors organized into a cluster, ...

journal_title：Nature cell biology

authors： Yin CC,Lai FA

更新日期：2000-09-01 00:00:00

abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...

journal_title：Nature cell biology

authors： Kaltschmidt JA,Davidson CM,Brown NH,Brand AH

更新日期：2000-01-01 00:00:00

abstract：:Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...

journal_title：Nature cell biology

authors： Carmo-Fonseca M,Mendes-Soares L,Campos I

更新日期：2000-06-01 00:00:00

abstract：:Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP pro...

journal_title：Nature cell biology

authors： Maddika S,Chen J

更新日期：2009-04-01 00:00:00

abstract：:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributo...

journal_title：Nature cell biology

authors： Delaunay S,Frye M

更新日期：2019-05-01 00:00:00