An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.

abstract：:NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-as...

journal_title：Nature cell biology

authors： Sans N,Prybylowski K,Petralia RS,Chang K,Wang YX,Racca C,Vicini S,Wenthold RJ

更新日期：2003-06-01 00:00:00

abstract：:Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP pro...

journal_title：Nature cell biology

authors： Maddika S,Chen J

更新日期：2009-04-01 00:00:00

abstract：:Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recen...

journal_title：Nature cell biology

authors： Heinrich C,Spagnoli FM,Berninger B

更新日期：2015-03-01 00:00:00

abstract：:MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides in length. Increasing evidence implicates miRs in myocardial disease processes. Here we show that miR-199b is a direct calcineurin/NFAT target gene that increases in expression in mouse and human heart failure, and targets the nuc...

journal_title：Nature cell biology

authors： da Costa Martins PA,Salic K,Gladka MM,Armand AS,Leptidis S,el Azzouzi H,Hansen A,Coenen-de Roo CJ,Bierhuizen MF,van der Nagel R,van Kuik J,de Weger R,de Bruin A,Condorelli G,Arbones ML,Eschenhagen T,De Windt LJ

更新日期：2010-12-01 00:00:00

abstract：:Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. ...

journal_title：Nature cell biology

authors： Yahara Y,Barrientos T,Tang YJ,Puviindran V,Nadesan P,Zhang H,Gibson JR,Gregory SG,Diao Y,Xiang Y,Qadri YJ,Souma T,Shinohara ML,Alman BA

更新日期：2020-01-01 00:00:00

abstract：:Primary cilia are required for vertebrate cells to respond to specific intercellular signals. Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes. Primary cilia first appear on cells of the epiblast at E6...

journal_title：Nature cell biology

authors： Bangs FK,Schrode N,Hadjantonakis AK,Anderson KV

更新日期：2015-02-01 00:00:00

abstract：:Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...

journal_title：Nature cell biology

authors： Viotti M,Nowotschin S,Hadjantonakis AK

更新日期：2014-12-01 00:00:00

abstract：:FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known. Here, we report that in the developing Xenopus and mouse forebrain, FoxG1 is nuclear in progenitor cells but cytoplasmic in diff...

journal_title：Nature cell biology

authors： Regad T,Roth M,Bredenkamp N,Illing N,Papalopulu N

更新日期：2007-05-01 00:00:00

abstract：:Several subunits of the class III phosphatidylinositol-3-OH kinase (PI(3)K-III) complex are known as tumour suppressors. Here we uncover a function for this complex and its catalytic product phosphatidylinositol-3-phosphate (PtdIns(3)P) in cytokinesis. We show that PtdIns(3)P localizes to the midbody during cytokinesi...

journal_title：Nature cell biology

authors： Sagona AP,Nezis IP,Pedersen NM,Liestøl K,Poulton J,Rusten TE,Skotheim RI,Raiborg C,Stenmark H

更新日期：2010-04-01 00:00:00

abstract：:Nutrient availability is central for T-cell functions and immune responses. Here we report that CD8+ T-cell activation and anti-tumour responses are strongly potentiated by the non-essential amino acid Asn. Increased Asn levels enhance CD8+ T-cell activation and effector functions against tumour cells in vitro and in ...

journal_title：Nature cell biology

authors： Wu J,Li G,Li L,Li D,Dong Z,Jiang P

更新日期：2021-01-01 00:00:00

abstract：:The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....

journal_title：Nature cell biology

authors： van der Laan M,Meinecke M,Dudek J,Hutu DP,Lind M,Perschil I,Guiard B,Wagner R,Pfanner N,Rehling P

更新日期：2007-10-01 00:00:00

abstract：:Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

journal_title：Nature cell biology

authors： Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

更新日期：2019-02-01 00:00:00

abstract：:The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...

journal_title：Nature cell biology

authors： Lüders J

更新日期：2012-11-01 00:00:00

abstract：:ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardio...

journal_title：Nature cell biology

authors： David R,Brenner C,Stieber J,Schwarz F,Brunner S,Vollmer M,Mentele E,Müller-Höcker J,Kitajima S,Lickert H,Rupp R,Franz WM

更新日期：2008-03-01 00:00:00

abstract：:Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellular adaptation in ki...

journal_title：Nature cell biology

authors： Miceli C,Roccio F,Penalva-Mousset L,Burtin M,Leroy C,Nemazanyy I,Kuperwasser N,Pontoglio M,Friedlander G,Morel E,Terzi F,Codogno P,Dupont N

更新日期：2020-09-01 00:00:00

abstract：:The store-operated calcium channel (SOC) located in the plasma membrane (PM) mediates capacitative entry of extracellular calcium after depletion of intracellular calcium stores in the endoplasmic or sarcoplasmic reticulum (ER/SR). An intimate interaction between the PM and the ER/SR is essential for the operation of ...

journal_title：Nature cell biology

authors： Pan Z,Yang D,Nagaraj RY,Nosek TA,Nishi M,Takeshima H,Cheng H,Ma J

更新日期：2002-05-01 00:00:00

abstract：:To generate the various tissues and organs that build up the adult body, plants and animals require organized formative cell divisions and correct cell specification. In plants, these processes are controlled mainly by phytohormones and transcriptional networks. Recently, ligand-receptor-like kinase signalling pathway...

journal_title：Nature cell biology

authors： De Smet I,Voss U,Jürgens G,Beeckman T

更新日期：2009-10-01 00:00:00

abstract：:Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromoso...

journal_title：Nature cell biology

authors： Balestrini A,Cosentino C,Errico A,Garner E,Costanzo V

更新日期：2010-05-01 00:00:00

abstract：:KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a functional genomic screen for genes that bypass RAS(V12)-induced senescence. However, in untransformed cells, KLF4 acts as a potent inhibitor of proliferation. KLF...

journal_title：Nature cell biology

authors： Rowland BD,Bernards R,Peeper DS

更新日期：2005-11-01 00:00:00

abstract：:The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion,...

journal_title：Nature cell biology

authors： Petridou NI,Spiró Z,Heisenberg CP

更新日期：2017-05-31 00:00:00

abstract：:Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a mod...

journal_title：Nature cell biology

authors： Hansen KH,Bracken AP,Pasini D,Dietrich N,Gehani SS,Monrad A,Rappsilber J,Lerdrup M,Helin K

更新日期：2008-11-01 00:00:00

abstract：:Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin d...

journal_title：Nature cell biology

authors： Grintsevich EE,Yesilyurt HG,Rich SK,Hung RJ,Terman JR,Reisler E

更新日期：2016-08-01 00:00:00

abstract：:The most dangerous insults to the genome's integrity are those that break both strands of the DNA. Double-strand breaks can be repaired by homologous recombination; in this conserved mechanism, a global genomic homology search finds sequences similar to those near the break, and uses them as a template for DNA synthes...

journal_title：Nature cell biology

authors： Agmon N,Liefshitz B,Zimmer C,Fabre E,Kupiec M

更新日期：2013-06-01 00:00:00

abstract：:Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...

journal_title：Nature cell biology

authors： Daboussi L,Costaguta G,Payne GS

更新日期：2012-02-19 00:00:00

abstract：:Phosphoinositide 3-kinase (PI(3)K) is a unique enzyme characterized by both lipid and protein kinase activities. Here, we demonstrate a requirement for the protein kinase activity of PI(3)K in agonist-dependent beta-adrenergic receptor (betaAR) internalization. Using PI(3)K mutants with either protein or lipid phospho...

journal_title：Nature cell biology

authors： Naga Prasad SV,Jayatilleke A,Madamanchi A,Rockman HA

更新日期：2005-08-01 00:00:00

abstract：:Filament-forming cytoskeletal proteins are essential for the structure and organization of all cells. Bacterial homologues of the major eukaryotic cytoskeletal families have now been discovered, but studies suggest that yet more remain to be identified. We demonstrate that the metabolic enzyme CTP synthase (CtpS) form...

journal_title：Nature cell biology

authors： Ingerson-Mahar M,Briegel A,Werner JN,Jensen GJ,Gitai Z

更新日期：2010-08-01 00:00:00

abstract：:Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. Here, we discovered an unexpected role for yeast dynein light chain (Dyn2) in the NPC. Dyn2 is a previously undescribed nucleoporin that functions as molecular glue to dimerize and stabilize the Nup82-Nsp1-Nup159...

journal_title：Nature cell biology

authors： Stelter P,Kunze R,Flemming D,Höpfner D,Diepholz M,Philippsen P,Böttcher B,Hurt E

更新日期：2007-07-01 00:00:00

abstract：:Actin networks drive many essential cellular processes, including cell migration, cytokinesis and tissue morphogenesis. However, how cells organize and regulate dynamic actin networks that consist of long, unbranched actin filaments is only poorly understood. This study in mouse oocytes reveals that cells can use vesi...

journal_title：Nature cell biology

authors： Holubcová Z,Howard G,Schuh M

更新日期：2013-08-01 00:00:00

abstract：:The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126(*), a microRNA pair derived from a...

journal_title：Nature cell biology

authors： Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

更新日期：2013-03-01 00:00:00

abstract：:For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked to oncogenesis and have been implicated in the regulation of chromosome-microtubule attachments. Although loss of Aurora ...

journal_title：Nature cell biology

authors： Lampson MA,Renduchitala K,Khodjakov A,Kapoor TM

更新日期：2004-03-01 00:00:00