Abstract：
:The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Delaunay S,Frye Mdoi
10.1038/s41556-019-0319-0subject
Has Abstractpub_date
2019-05-01 00:00:00pages
552-559issue
5eissn
1465-7392issn
1476-4679pii
10.1038/s41556-019-0319-0journal_volume
21pub_type
杂志文章,评审abstract：:Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells. ...
journal_title：Nature cell biology
pub_type： 评论,新闻
doi：10.1038/ncb1010-928
更新日期：2010-10-01 00:00:00
abstract：:The anaphase-promoting complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin. Lys 48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradation of cyclin B...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2425
更新日期：2012-01-29 00:00:00
abstract：:Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-017-0017-8
更新日期：2018-02-01 00:00:00
abstract：:In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and brain ventricles. The development and function of these organs critically depend on efficient directional fluid flow ensured by the alignment of ciliary beating. To identify the mechanisms involved in this process, we analysed ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2040
更新日期：2010-04-01 00:00:00
abstract：:Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3534
更新日期：2017-06-01 00:00:00
abstract：:Protein ubiquitination regulates many cellular processes, including protein degradation, signal transduction, DNA repair and cell division. In the classical model, a uniform polyubiquitin chain that is linked through Lys 48 is required for recognition and degradation by the 26S proteasome. Here, we used a reconstitute...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1436
更新日期：2006-07-01 00:00:00
abstract：:Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...
journal_title：Nature cell biology
pub_type： 更正并重新发布的文章,杂志文章
doi：10.1038/ncb770
更新日期：2002-03-01 00:00:00
abstract：:Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of ac...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2307
更新日期：2011-08-14 00:00:00
abstract：:Stereocilia are microvilli-derived mechanosensory organelles that are arranged in rows of graded heights on the apical surface of inner-ear hair cells. The 'staircase'-like architecture of stereocilia bundles is necessary to detect sound and head movement, and is achieved through differential elongation of the actin c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1219
更新日期：2005-02-01 00:00:00
abstract：:Haematopoietic stem cells (HSCs) arise in the developing aorta during embryogenesis. The number of HSC clones born has been estimated through transplantation, but experimental approaches to assess the absolute number of forming HSCs in a native setting have remained challenging. Here, we applied single-cell and clonal...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3444
更新日期：2017-01-01 00:00:00
abstract：:Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. ...
journal_title：Nature cell biology
pub_type： 新闻
doi：10.1038/ncb2599
更新日期：2012-10-01 00:00:00
abstract：:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2133
更新日期：2011-01-01 00:00:00
abstract：:Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in sig...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb884
更新日期：2002-12-01 00:00:00
abstract：:The most dangerous insults to the genome's integrity are those that break both strands of the DNA. Double-strand breaks can be repaired by homologous recombination; in this conserved mechanism, a global genomic homology search finds sequences similar to those near the break, and uses them as a template for DNA synthes...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2745
更新日期：2013-06-01 00:00:00
abstract：:Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...
journal_title：Nature cell biology
pub_type： 社论
doi：10.1038/ncb1109-1273a
更新日期：2009-11-01 00:00:00
abstract：:It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential. ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb0202-e25
更新日期：2002-02-01 00:00:00
abstract：:Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3645
更新日期：2017-11-29 00:00:00
abstract：:The retinoblastoma protein (pRB) negatively regulates the progression from G1 to S phase of the cell cycle, in part, by repressing E2F-dependent transcription. pRB also possesses E2F-independent functions that contribute to cell-cycle control--for example, during pRB-mediated cell-cycle arrest pRB associates with Skp2...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1532
更新日期：2007-02-01 00:00:00
abstract：:Direct reprogramming by forced expression of transcription factors can convert one cell type into another. Thus, desired cell types can be generated bypassing pluripotency. However, direct reprogramming towards renal cells remains an unmet challenge. Here, we identify renal cell fate-inducing factors on the basis of t...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3437
更新日期：2016-12-01 00:00:00
abstract：:Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of the molecular mechanisms by which adhesion disassembly is regulated, including the contributions of adhesion adaptor proteins...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1175
更新日期：2004-10-01 00:00:00
abstract：:While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-019-0397-z
更新日期：2019-10-01 00:00:00
abstract：:Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating bot...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb3086
更新日期：2015-01-01 00:00:00
abstract：:Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb3059
更新日期：2014-11-01 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates embryonic development and tissue homeostasis; however, aberrations of its activity occur in cancer. TGF-beta signals through its Type II and Type I receptors (TbetaRII and TbetaRI) causing phosphorylation of Smad proteins. TGF-beta...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1780
更新日期：2008-10-01 00:00:00
abstract：:The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although the biochemical c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3179
更新日期：2015-07-01 00:00:00
abstract：:Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cells must bypass. Here we show by whole-genome single-nucleotide bi...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2879
更新日期：2013-12-01 00:00:00
abstract：:Here we show that segregation of homologous chromosomes and that of sister chromatids are differentially regulated in Xenopus and possibly in other higher eukaryotes. Upon hormonal stimulation, Xenopus oocytes microinjected with antibodies against the anaphase-promoting complex (APC) activator Fizzy or the APC core su...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35050607
更新日期：2001-01-01 00:00:00
abstract：:The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3421
更新日期：2016-11-01 00:00:00
abstract：:Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets as phospho-sens...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/s41556-019-0328-z
更新日期：2019-06-01 00:00:00
abstract：:The asymmetric segregation of cell-fate determinants and the generation of daughter cells of different sizes rely on the correct orientation and position of the mitotic spindle. In the Drosophila embryo, the determinant Prospero is localized basally and is segregated equally to daughters of similar cell size during ep...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/71323
更新日期：2000-01-01 00:00:00
