当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > Senescent cells harbour features of the cancer epigenome.

Senescent cells harbour features of the cancer epigenome.

Abstract：

:Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cells must bypass. Here we show by whole-genome single-nucleotide bisulfite sequencing that replicative senescent human cells exhibit widespread DNA hypomethylation and focal hypermethylation. Hypomethylation occurs preferentially at gene-poor, late-replicating, lamin-associated domains and is linked to mislocalization of the maintenance DNA methyltransferase (DNMT1) in cells approaching senescence. Low-level gains of methylation are enriched in CpG islands, including at genes whose methylation and silencing is thought to promote cancer. Gains and losses of methylation in replicative senescence are thus qualitatively similar to those in cancer, and this 'reprogrammed' methylation landscape is largely retained when cells bypass senescence. Consequently, the DNA methylome of senescent cells might promote malignancy, if these cells escape the proliferative barrier.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Cruickshanks HA,McBryan T,Nelson DM,Vanderkraats ND,Shah PP,van Tuyn J,Singh Rai T,Brock C,Donahue G,Dunican DS,Drotar ME,Meehan RR,Edwards JR,Berger SL,Adams PD

doi

10.1038/ncb2879

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1495-506

issue

12

eissn

1465-7392

issn

1476-4679

pii

ncb2879

journal_volume

15

pub_type

杂志文章

相关文献

NATURE CELL BIOLOGY文献大全
  • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

    abstract：:Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints. Histone H2AX, p53 binding-protein 1 (53BP1) and Chk2 are targets of ATM-mediated phosphorylation, but little is known about their roles in sig...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb884

    authors： Fernandez-Capetillo O,Chen HT,Celeste A,Ward I,Romanienko PJ,Morales JC,Naka K,Xia Z,Camerini-Otero RD,Motoyama N,Carpenter PB,Bonner WM,Chen J,Nussenzweig A

    更新日期：2002-12-01 00:00:00

  • Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells.

    abstract：:Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2719

    authors： Tanaka T,Komai Y,Tokuyama Y,Yanai H,Ohe S,Okazaki K,Ueno H

    更新日期：2013-05-01 00:00:00

  • Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs.

    abstract：:The actin filament (F-actin) cytoskeleton associates dynamically with the plasma membrane and is thus ideally positioned to participate in endocytosis. Indeed, a wealth of genetic and biochemical evidence has confirmed that actin interacts with components of the endocytic machinery, although its precise function in en...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1025

    authors： Sokac AM,Co C,Taunton J,Bement W

    更新日期：2003-08-01 00:00:00

  • Safeguarding ART.

    abstract：:Assisted reproductive technologies (ART) are exceptional among clinical therapies, as unlike most medical procedures, ART have generational consequences. Further, human embryo research in the US has been sponsored solely by the private sector and, until recent biotechnology forays into human embryonic stem cell (hESC)...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb-nm-fertilityS19

    authors： Schatten GP

    更新日期：2002-10-01 00:00:00

  • VHL takes HIF's breath away.

    abstract：:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dep...

    journal_title：Nature cell biology

    pub_type： 评论,新闻

    doi：10.1038/35017129

    authors： Krek W

    更新日期：2000-07-01 00:00:00

  • The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.

    abstract：:While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0397-z

    authors： Karoutas A,Szymanski W,Rausch T,Guhathakurta S,Rog-Zielinska EA,Peyronnet R,Seyfferth J,Chen HR,de Leeuw R,Herquel B,Kimura H,Mittler G,Kohl P,Medalia O,Korbel JO,Akhtar A

    更新日期：2019-10-01 00:00:00

  • Correcting improper chromosome-spindle attachments during cell division.

    abstract：:For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked to oncogenesis and have been implicated in the regulation of chromosome-microtubule attachments. Although loss of Aurora ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1102

    authors： Lampson MA,Renduchitala K,Khodjakov A,Kapoor TM

    更新日期：2004-03-01 00:00:00

  • CRISPR mutagenesis screening of mice.

    abstract：: ...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/s41556-018-0224-y

    authors： Serebrenik YV,Shalem O

    更新日期：2018-11-01 00:00:00

  • Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network.

    abstract：:Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes. Two main types of clathrin adaptor act in TGN-endosome traffic: GGA proteins and the...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2427

    authors： Daboussi L,Costaguta G,Payne GS

    更新日期：2012-02-19 00:00:00

  • Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation.

    abstract：:Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse with autophagosomes to form autolysosomes. Following starvation-induced autophagy, nascent lysosomes are formed from autolysosomal membranes through an evolutionarily conserved cellular process, autophagic lysosome reformation (ALR), w...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2557

    authors： Rong Y,Liu M,Ma L,Du W,Zhang H,Tian Y,Cao Z,Li Y,Ren H,Zhang C,Li L,Chen S,Xi J,Yu L

    更新日期：2012-09-01 00:00:00

  • Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling.

    abstract：:Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified a unique population of tissue-resident ductal mac...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-0505-0

    authors： Dawson CA,Pal B,Vaillant F,Gandolfo LC,Liu Z,Bleriot C,Ginhoux F,Smyth GK,Lindeman GJ,Mueller SN,Rios AC,Visvader JE

    更新日期：2020-05-01 00:00:00

  • The impact of cellular metabolism on chromatin dynamics and epigenetics.

    abstract：:The substrates used to modify nucleic acids and chromatin are affected by nutrient availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a fundamental component of chromatin status and thereby of genome regulation. Here we describe the biochemical and genetic principles of how meta...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb3629

    authors： Reid MA,Dai Z,Locasale JW

    更新日期：2017-11-01 00:00:00

  • Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

    abstract：:Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0271-4

    authors： Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

    更新日期：2019-02-01 00:00:00

  • Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

    abstract：:Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA precursors and ribosomal proteins. These defects were associated with red...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0127-y

    authors： Lessard F,Igelmann S,Trahan C,Huot G,Saint-Germain E,Mignacca L,Del Toro N,Lopes-Paciencia S,Le Calvé B,Montero M,Deschênes-Simard X,Bury M,Moiseeva O,Rowell MC,Zorca CE,Zenklusen D,Brakier-Gingras L,Bourdeau V,Oeffin

    更新日期：2018-07-01 00:00:00

  • EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.

    abstract：:The Notch1 gene has an important role in mammalian cell-fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signalling, we identified epidermal growth factor receptor (EGFR) as a ke...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1750

    authors： Kolev V,Mandinova A,Guinea-Viniegra J,Hu B,Lefort K,Lambertini C,Neel V,Dummer R,Wagner EF,Dotto GP

    更新日期：2008-08-01 00:00:00

  • Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif.

    abstract：:Clathrin-coated vesicles (CCVs) are a central component of endocytosis and traffic between the trans-Golgi network (TGN) and endosomes. Although endocytic CCV formation is well characterized, much less is known about CCV formation at internal membranes. Here we describe two epsin amino-terminal homology (ENTH) domain-...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb901

    authors： Duncan MC,Costaguta G,Payne GS

    更新日期：2003-01-01 00:00:00

  • Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

    abstract：:The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3573

    authors： Hanssen LLP,Kassouf MT,Oudelaar AM,Biggs D,Preece C,Downes DJ,Gosden M,Sharpe JA,Sloane-Stanley JA,Hughes JR,Davies B,Higgs DR

    更新日期：2017-08-01 00:00:00

  • NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

    abstract：:Somatic cell reprogramming by exogenous factors requires cooperation with transcriptional co-activators and co-repressors to effectively remodel the epigenetic environment. How this interplay is regulated remains poorly understood. Here, we demonstrate that NCoR/SMRT co-repressors bind to pluripotency loci to create a...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-018-0047-x

    authors： Zhuang Q,Li W,Benda C,Huang Z,Ahmed T,Liu P,Guo X,Ibañez DP,Luo Z,Zhang M,Abdul MM,Yang Z,Yang J,Huang Y,Zhang H,Huang D,Zhou J,Zhong X,Zhu X,Fu X,Fan W,Liu Y,Xu Y,Ward C,Khan MJ,Kanwal S,Mirza B,Tor

    更新日期：2018-04-01 00:00:00

  • Dynein branches out.

    abstract：:Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites. ...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/ncb1008-1131

    authors： Tear G

    更新日期：2008-10-01 00:00:00

  • Teaching tumour suppressors new tricks.

    abstract：:Examination of the tumour suppressor adenomatous polyposis coli (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule cytoskeleton, supporting the idea that APC has an important function in cell migration. ...

    journal_title：Nature cell biology

    pub_type： 新闻,评审

    doi：10.1038/35008685

    authors： McCartney BM,Peifer M

    更新日期：2000-04-01 00:00:00

  • WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.

    abstract：:Lamellipodia/ruffles and filopodia are protruding organelles containing short and highly branched or long and unbranched actin filaments, respectively. The microscopic morphology, dynamic development and protein signature of both lamellipodia/ruffles and filopodia have been investigated; however, little is known about...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1745

    authors： Beli P,Mascheroni D,Xu D,Innocenti M

    更新日期：2008-07-01 00:00:00

  • Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

    abstract：:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2133

    authors： Hidalgo-Carcedo C,Hooper S,Chaudhry SI,Williamson P,Harrington K,Leitinger B,Sahai E

    更新日期：2011-01-01 00:00:00

  • Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.

    abstract：:To study the role of the BH3 domain in mediating pro-apoptotic and anti-apoptotic activities of Bcl-2 family members, we identified a series of novel small molecules (BH3Is) that inhibit the binding of the Bak BH3 peptide to Bcl-xL. NMR analyses revealed that BH3Is target the BH3-binding pocket of Bcl-xL. Inhibitors s...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35055085

    authors： Degterev A,Lugovskoy A,Cardone M,Mulley B,Wagner G,Mitchison T,Yuan J

    更新日期：2001-02-01 00:00:00

  • ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells.

    abstract：:Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show that GALA induces th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-00590-w

    authors： Ros M,Nguyen AT,Chia J,Le Tran S,Le Guezennec X,McDowall R,Vakhrushev S,Clausen H,Humphries MJ,Saltel F,Bard FA

    更新日期：2020-11-01 00:00:00

  • The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.

    abstract：:The spindle checkpoint ensures accurate chromosome segregation by delaying cell-cycle progression until all sister kinetochores capture microtubules from opposite poles and come under tension (for reviews, see refs 1, 2). Although the checkpoint is activated by either the lack of kinetochore-microtubule attachments or...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1341

    authors： Pinsky BA,Kung C,Shokat KM,Biggins S

    更新日期：2006-01-01 00:00:00

  • S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction.

    abstract：:Treatment of cultured vertebrate neurons with nitric oxide leads to growth-cone collapse, axon retraction and the reconfiguration of axonal microtubules. We show that the light chain of microtubule-associated protein (MAP) 1B is a substrate for S-nitrosylation in vivo, in cultured cells and in vitro. S-nitrosylation o...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1625

    authors： Stroissnigg H,Trancíková A,Descovich L,Fuhrmann J,Kutschera W,Kostan J,Meixner A,Nothias F,Propst F

    更新日期：2007-09-01 00:00:00

  • COPII and the regulation of protein sorting in mammals.

    abstract：:Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout ...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb2390

    authors： Zanetti G,Pahuja KB,Studer S,Shim S,Schekman R

    更新日期：2011-12-22 00:00:00

  • Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein.

    abstract：:The formation of branched epithelial networks is fundamental to the development of many organs, such as the lung, the kidney or the vasculature. Little is known about the mechanisms that control cell rearrangements during tubulogenesis and regulate the size of individual tubes. Recent studies indicate that whereas the...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1049

    authors： Jaźwińska A,Ribeiro C,Affolter M

    更新日期：2003-10-01 00:00:00

  • The expression of Sox17 identifies and regulates haemogenic endothelium.

    abstract：:Although it is well recognized that haematopoietic stem cells (HSCs) develop from a specialized population of endothelial cells known as haemogenic endothelium, the regulatory pathways that control this transition are not well defined. Here we identify Sox17 as a key regulator of haemogenic endothelial development. An...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2724

    authors： Clarke RL,Yzaguirre AD,Yashiro-Ohtani Y,Bondue A,Blanpain C,Pear WS,Speck NA,Keller G

    更新日期：2013-05-01 00:00:00

  • Chromosomes at loose ends.

    abstract：:Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the asso...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/ncb3321

    authors： Nakajima Y,Haber JE

    更新日期：2016-03-01 00:00:00