Abstract：
:NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-associated protein 102 (SAP102) interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Our results show that interactions between SAP102 and Sec8 are involved in the delivery of NMDARs to the cell surface in heterologous cells and neurons. Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Sans N,Prybylowski K,Petralia RS,Chang K,Wang YX,Racca C,Vicini S,Wenthold RJdoi
10.1038/ncb990keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
520-30issue
6eissn
1465-7392issn
1476-4679pii
ncb990journal_volume
5pub_type
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