Abstract：
:Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Here we analyse ErbB4-deficient mice, and find that morphological differences between wild-type and mutant cranial ganglia correlate with aberrant migration of a subpopulation of hindbrain-derived cranial neural crest cells within the paraxial mesenchyme environment. In transplantation experiments using new grafting techniques in cultured mouse embryos, we determine that this phenotype is non-cell-autonomous: wild-type and mutant neural crest cells both migrate in a pattern consistent with the host environment, deviating from their normal pathway only when transplanted into mutant embryos. ErbB4 signalling events within the hindbrain therefore provide patterning information to cranial paraxial mesenchyme that is essential for the proper migration of neural crest cells.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Golding JP,Trainor P,Krumlauf R,Gassmann Mdoi
10.1038/35000058keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
103-9issue
2eissn
1465-7392issn
1476-4679journal_volume
2pub_type
杂志文章abstract：:In the version of this article originally published, parts of Figure 5 were misaligned because of a shift during production. In a, one data point was outside of the graph border. In b, axes lines were not connected, and graph lines did not reach the data points. In c and d, the axes lines were not connected. In e and ...
journal_title：Nature cell biology
pub_type： 杂志文章,已发布勘误
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pub_type： 杂志文章,已发布勘误
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pub_type： 杂志文章
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pub_type： 评论,杂志文章
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更新日期：2016-11-01 00:00:00
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pub_type： 评论,新闻
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更新日期：2012-04-02 00:00:00
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更新日期：2000-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
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更新日期：2018-08-01 00:00:00
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更新日期：2021-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/ncb3060
更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2016-04-27 00:00:00
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pub_type： 杂志文章
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更新日期：2012-02-05 00:00:00
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journal_title：Nature cell biology
pub_type： 新闻
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更新日期：2012-10-01 00:00:00
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journal_title：Nature cell biology
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journal_title：Nature cell biology
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