Abstract:
:Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Celià-Terrassa T,Kang Ydoi
10.1038/s41556-018-0145-9subject
Has Abstractpub_date
2018-08-01 00:00:00pages
868-877issue
8eissn
1465-7392issn
1476-4679pii
10.1038/s41556-018-0145-9journal_volume
20pub_type
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