当前位置： SCI文献检索 > NATURE CELL BIOLOGY期刊下所有文献 > Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.

Abstract：

:Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of Ang1-Tie2 signalling in developmental vascular formation. It remains elusive how the Tie2 signalling pathway plays distinct roles in both vascular quiescence and angiogenesis. We demonstrate here that Ang1 bridges Tie2 at cell-cell contacts, resulting in trans-association of Tie2 in the presence of cell-cell contacts. In clear contrast, in isolated cells, extracellular matrix-bound Ang1 locates Tie2 at cell-substratum contacts. Furthermore, Tie2 activated at cell-cell or cell-substratum contacts leads to preferential activation of Akt and Erk, respectively. Microarray analyses and real-time PCR validation clearly show the differential gene expression profile in vascular endothelial cells upon Ang1 stimulation in the presence or absence of cell-cell contacts, implying downstream signalling is dependent upon the spatial localization of Tie2.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Fukuhara S,Sako K,Minami T,Noda K,Kim HZ,Kodama T,Shibuya M,Takakura N,Koh GY,Mochizuki N

doi

10.1038/ncb1714

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

513-26

issue

5

eissn

1465-7392

issn

1476-4679

pii

ncb1714

journal_volume

10

pub_type

杂志文章

相关文献

NATURE CELL BIOLOGY文献大全
  • A transient pool of nuclear F-actin at mitotic exit controls chromatin organization.

    abstract：:Re-establishment of nuclear structure and chromatin organization after cell division is integral for genome regulation or development and is frequently altered during cancer progression. The mechanisms underlying chromatin expansion in daughter cells remain largely unclear. Here, we describe the transient formation of...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3641

    authors： Baarlink C,Plessner M,Sherrard A,Morita K,Misu S,Virant D,Kleinschnitz EM,Harniman R,Alibhai D,Baumeister S,Miyamoto K,Endesfelder U,Kaidi A,Grosse R

    更新日期：2017-12-01 00:00:00

  • CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

    abstract：:Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is infl...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2423

    authors： Logarinho E,Maffini S,Barisic M,Marques A,Toso A,Meraldi P,Maiato H

    更新日期：2012-02-05 00:00:00

  • New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.

    abstract：:Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35036326

    authors： Hinuma S,Shintani Y,Fukusumi S,Iijima N,Matsumoto Y,Hosoya M,Fujii R,Watanabe T,Kikuchi K,Terao Y,Yano T,Yamamoto T,Kawamata Y,Habata Y,Asada M,Kitada C,Kurokawa T,Onda H,Nishimura O,Tanaka M,Ibata Y,Fujino M

    更新日期：2000-10-01 00:00:00

  • Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.

    abstract：:Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic mark that specifies centromere identity. Here we identify the essential centromere...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1899

    authors： Carroll CW,Silva MC,Godek KM,Jansen LE,Straight AF

    更新日期：2009-07-01 00:00:00

  • Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development.

    abstract：:Glycogen has long been considered to have a function in energy metabolism. However, our recent study indicated that glycogen metabolism, directed by cytosolic phosphoenolpyruvate carboxykinase Pck1, controls the formation and maintenance of CD8+ memory T (Tmem) cells by regulating redox homeostasis1. This unusual meta...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0440-0

    authors： Zhang H,Tang K,Ma J,Zhou L,Liu J,Zeng L,Zhu L,Xu P,Chen J,Wei K,Liang X,Lv J,Xie J,Liu Y,Wan Y,Huang B

    更新日期：2020-01-01 00:00:00

  • PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

    abstract：:Mitochondria drive apoptosis by releasing pro-apoptotic proteins that promote caspase activation in the cytosol. The rhomboid protease PARL, an intramembrane cleaving peptidase in the inner membrane, regulates mitophagy and plays an ill-defined role in apoptosis. Here, we employed PARL-based proteomics to define its s...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3488

    authors： Saita S,Nolte H,Fiedler KU,Kashkar H,Venne AS,Zahedi RP,Krüger M,Langer T

    更新日期：2017-04-01 00:00:00

  • The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.

    abstract：:Formation of a bipolar spindle is essential for faithful chromosome segregation at mitosis. Because centrosomes define spindle poles, defects in centrosome number and structural organization can lead to a loss of bipolarity. In addition, microtubule-mediated pulling and pushing forces acting on centrosomes and chromos...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1474

    authors： Oshimori N,Ohsugi M,Yamamoto T

    更新日期：2006-10-01 00:00:00

  • Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.

    abstract：:The cyclical protrusion and retraction of the leading edge is a hallmark of many migrating cells involved in processes such as development, inflammation and tumorigenesis. The molecular identity of the signalling mechanisms that control these cycles has remained unknown. Here, we used live-cell imaging of biosensors t...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2231

    authors： Tkachenko E,Sabouri-Ghomi M,Pertz O,Kim C,Gutierrez E,Machacek M,Groisman A,Danuser G,Ginsberg MH

    更新日期：2011-06-01 00:00:00

  • Replicating repetitive DNA.

    abstract：:The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particu...

    journal_title：Nature cell biology

    pub_type： 评论,杂志文章

    doi：10.1038/ncb3367

    authors： Tognetti S,Speck C

    更新日期：2016-05-27 00:00:00

  • The base of the proteasome regulatory particle exhibits chaperone-like activity.

    abstract：:Protein substrates of the proteasome must apparently be unfolded and translocated through a narrow channel to gain access to the proteolytic active sites of the enzyme. Protein folding in vivo is mediated by molecular chaperones. Here, to test for chaperone activity of the proteasome, we assay the reactivation of dena...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/12043

    authors： Braun BC,Glickman M,Kraft R,Dahlmann B,Kloetzel PM,Finley D,Schmidt M

    更新日期：1999-08-01 00:00:00

  • Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.

    abstract：:Mouse embryos with a loss-of-function mutation in the gene encoding the receptor tyrosine kinase ErbB4 exhibit misprojections of cranial sensory ganglion afferent axons. Here we analyse ErbB4-deficient mice, and find that morphological differences between wild-type and mutant cranial ganglia correlate with aberrant mi...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/35000058

    authors： Golding JP,Trainor P,Krumlauf R,Gassmann M

    更新日期：2000-02-01 00:00:00

  • COPII and the regulation of protein sorting in mammals.

    abstract：:Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout ...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/ncb2390

    authors： Zanetti G,Pahuja KB,Studer S,Shim S,Schekman R

    更新日期：2011-12-22 00:00:00

  • Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.

    abstract：:Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or gamma-irradiation. The preRC assembles on replication origins at the end of mitosis and durin...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1061

    authors： Higa LA,Mihaylov IS,Banks DP,Zheng J,Zhang H

    更新日期：2003-11-01 00:00:00

  • To be or not to be in the nucleolus.

    abstract：:Compartmentalization has long been known to have a key role in regulation of cellular processes. By keeping enzymes and regulatory complexes in compartments where the delivery of substrate or exit of product is controlled, competing reactions can occur simultaneously in different parts of the cell. Moreover, spatial c...

    journal_title：Nature cell biology

    pub_type： 杂志文章,评审

    doi：10.1038/35014078

    authors： Carmo-Fonseca M,Mendes-Soares L,Campos I

    更新日期：2000-06-01 00:00:00

  • Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.

    abstract：:Cancer-induced immune responses affect tumour progression and therapeutic response. In multiple murine models and clinical datasets, we identified large variations of neutrophils and macrophages that define 'immune subtypes' of triple-negative breast cancer (TNBC), including neutrophil-enriched (NES) and macrophage-en...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0373-7

    authors： Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,

    更新日期：2019-09-01 00:00:00

  • SHARPIN is an endogenous inhibitor of β1-integrin activation.

    abstract：:Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1-integrins, but the counteracting inhibiting mechanisms are poorly defined. We identified SHARPIN as an important inactivator of β1-integrins in an RNAi screen. SHARPIN inhibited β1-integrin ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2340

    authors： Rantala JK,Pouwels J,Pellinen T,Veltel S,Laasola P,Mattila E,Potter CS,Duffy T,Sundberg JP,Kallioniemi O,Askari JA,Humphries MJ,Parsons M,Salmi M,Ivaska J

    更新日期：2011-09-25 00:00:00

  • Safeguarding ART.

    abstract：:Assisted reproductive technologies (ART) are exceptional among clinical therapies, as unlike most medical procedures, ART have generational consequences. Further, human embryo research in the US has been sponsored solely by the private sector and, until recent biotechnology forays into human embryonic stem cell (hESC)...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb-nm-fertilityS19

    authors： Schatten GP

    更新日期：2002-10-01 00:00:00

  • Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling.

    abstract：:Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland function, their diversity has not been fully addressed. By exploiting high-resolution three-dimensional imaging and flow cytometry, we identified a unique population of tissue-resident ductal mac...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-020-0505-0

    authors： Dawson CA,Pal B,Vaillant F,Gandolfo LC,Liu Z,Bleriot C,Ginhoux F,Smyth GK,Lindeman GJ,Mueller SN,Rios AC,Visvader JE

    更新日期：2020-05-01 00:00:00

  • Tensile forces govern germ-layer organization in zebrafish.

    abstract：:Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1705

    authors： Krieg M,Arboleda-Estudillo Y,Puech PH,Käfer J,Graner F,Müller DJ,Heisenberg CP

    更新日期：2008-04-01 00:00:00

  • XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules.

    abstract：:Metaphase spindles are microtubule-based structures that use a multitude of proteins to modulate their morphology and function. Today, we understand many details of microtubule assembly, the role of microtubule-associated proteins, and the action of molecular motors. Ultimately, the challenge remains to understand how...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2834

    authors： Reber SB,Baumgart J,Widlund PO,Pozniakovsky A,Howard J,Hyman AA,Jülicher F

    更新日期：2013-09-01 00:00:00

  • Stem cell quiescence acts as a tumour suppressor in squamous tumours.

    abstract：:In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined c...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2889

    authors： White AC,Khuu JK,Dang CY,Hu J,Tran KV,Liu A,Gomez S,Zhang Z,Yi R,Scumpia P,Grigorian M,Lowry WE

    更新日期：2014-01-01 00:00:00

  • The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila.

    abstract：:Many extracellular signals are transmitted to the interior of the cell by receptors with seven membrane-spanning helices that trigger their effects by means of heterotrimeric guanine-nucleotide-binding regulatory proteins (G proteins). These G-protein-coupled receptors (GPCRs) control various physiological functions i...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1133

    authors： Cvejic S,Zhu Z,Felice SJ,Berman Y,Huang XY

    更新日期：2004-06-01 00:00:00

  • Arabidopsis cortical microtubules position cellulose synthase delivery to the plasma membrane and interact with cellulose synthase trafficking compartments.

    abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1886

    authors： Gutierrez R,Lindeboom JJ,Paredez AR,Emons AM,Ehrhardt DW

    更新日期：2009-07-01 00:00:00

  • Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.

    abstract：:The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucle...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb0901-809

    authors： Selva EM,Hong K,Baeg GH,Beverley SM,Turco SJ,Perrimon N,Häcker U

    更新日期：2001-09-01 00:00:00

  • ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

    abstract：:Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the Warburg effect by unclear mechanisms. Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Phosphor...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2629

    authors： Yang W,Zheng Y,Xia Y,Ji H,Chen X,Guo F,Lyssiotis CA,Aldape K,Cantley LC,Lu Z

    更新日期：2012-12-01 00:00:00

  • Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

    abstract：:During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and daughter centriole. This linker is disassembled at the onset of mitosis in a process known as centrosome disjunction, thereby facilitating centrosome separation and bipolar spindle formation. Th...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb2120

    authors： Mardin BR,Lange C,Baxter JE,Hardy T,Scholz SR,Fry AM,Schiebel E

    更新日期：2010-12-01 00:00:00

  • Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

    abstract：:Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen. This action of NO has both physiological and pathophysiological consequences. Here we report that endogenously generated NO, which disrupts the respiratory chain, may cause ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb1188

    authors： Xu W,Liu L,Charles IG,Moncada S

    更新日期：2004-11-01 00:00:00

  • EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

    abstract：:The emergence of resistance to poly-ADP-ribose polymerase inhibitors (PARPi) poses a threat to the treatment of BRCA1 and BRCA2 (BRCA1/2)-deficient tumours. Stabilization of stalled DNA replication forks is a recently identified PARPi-resistance mechanism that promotes genomic stability in BRCA1/2-deficient cancers. D...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3626

    authors： Rondinelli B,Gogola E,Yücel H,Duarte AA,van de Ven M,van der Sluijs R,Konstantinopoulos PA,Jonkers J,Ceccaldi R,Rottenberg S,D'Andrea AD

    更新日期：2017-11-01 00:00:00

  • Ankyrin repeat-containing N-Ank proteins shape cellular membranes.

    abstract：:Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several ...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/s41556-019-0381-7

    authors： Wolf D,Hofbrucker-MacKenzie SA,Izadi M,Seemann E,Steiniger F,Schwintzer L,Koch D,Kessels MM,Qualmann B

    更新日期：2019-10-01 00:00:00

  • F-actin dismantling through a redox-driven synergy between Mical and cofilin.

    abstract：:Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin d...

    journal_title：Nature cell biology

    pub_type： 杂志文章

    doi：10.1038/ncb3390

    authors： Grintsevich EE,Yesilyurt HG,Rich SK,Hung RJ,Terman JR,Reisler E

    更新日期：2016-08-01 00:00:00