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Homologue recognition during meiosis is associated with a change in chromatin conformation.

Abstract：

:During meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other. Here we show, by comparing the behaviour of wild-type wheat and wheat mutant for Ph1 (a suppressor of homeologous chromosome pairing), that when chromosomes recognise a partner to pair with, a conformational change to the chromatin is triggered in both partners that is followed by their intimate alignment [corrected]. Thus, a conformational change in the chromosomes at the onset of meiosis can be correlated directly with recognition.

journal_name

Nat Cell Biol

journal_title

Nature cell biology

authors

Prieto P,Shaw P,Moore G

doi

10.1038/ncb1168

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

906-8

issue

9

eissn

1465-7392

issn

1476-4679

pii

ncb1168

journal_volume

6

pub_type

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