In vivo reprogramming for tissue repair.

abstract：:Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstr...

journal_title：Nature cell biology

authors： Alanko J,Mai A,Jacquemet G,Schauer K,Kaukonen R,Saari M,Goud B,Ivaska J

更新日期：2015-11-01 00:00:00

abstract：:Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can ...

journal_title：Nature cell biology

authors： Wei Y,Chen YH,Li LY,Lang J,Yeh SP,Shi B,Yang CC,Yang JY,Lin CY,Lai CC,Hung MC

更新日期：2011-01-01 00:00:00

abstract：:To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human...

journal_title：Nature cell biology

authors： Alabert C,Bukowski-Wills JC,Lee SB,Kustatscher G,Nakamura K,de Lima Alves F,Menard P,Mejlvang J,Rappsilber J,Groth A

更新日期：2014-03-01 00:00:00

abstract：:Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. ...

journal_title：Nature cell biology

authors： Storici F,Tichon AE

更新日期：2017-11-29 00:00:00

abstract：:Here we evaluate the idea that the Golgi is in dynamic equilibrium with the endoplasmic reticulum (ER). In cytoplasts that lack the Golgi apparatus, no regrowth of the Golgi is observed, nor is any transport from the ER to the cell surface detected. However, introduction of the smallest measurable amount of Golgi (equ...

journal_title：Nature cell biology

authors： Pelletier L,Jokitalo E,Warren G

更新日期：2000-11-01 00:00:00

abstract：:While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation...

journal_title：Nature cell biology

authors： Karoutas A,Szymanski W,Rausch T,Guhathakurta S,Rog-Zielinska EA,Peyronnet R,Seyfferth J,Chen HR,de Leeuw R,Herquel B,Kimura H,Mittler G,Kohl P,Medalia O,Korbel JO,Akhtar A

更新日期：2019-10-01 00:00:00

abstract：:Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalie...

journal_title：Nature cell biology

authors： Jin Y,Muhl L,Burmakin M,Wang Y,Duchez AC,Betsholtz C,Arthur HM,Jakobsson L

更新日期：2017-06-01 00:00:00

abstract：:RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...

journal_title：Nature cell biology

authors： Fellmann C,Lowe SW

更新日期：2014-01-01 00:00:00

abstract：:Treatment of cultured vertebrate neurons with nitric oxide leads to growth-cone collapse, axon retraction and the reconfiguration of axonal microtubules. We show that the light chain of microtubule-associated protein (MAP) 1B is a substrate for S-nitrosylation in vivo, in cultured cells and in vitro. S-nitrosylation o...

journal_title：Nature cell biology

authors： Stroissnigg H,Trancíková A,Descovich L,Fuhrmann J,Kutschera W,Kostan J,Meixner A,Nothias F,Propst F

更新日期：2007-09-01 00:00:00

abstract：:Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanis...

journal_title：Nature cell biology

authors： Birchmeier W

更新日期：2016-04-27 00:00:00

abstract：:In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined c...

journal_title：Nature cell biology

authors： White AC,Khuu JK,Dang CY,Hu J,Tran KV,Liu A,Gomez S,Zhang Z,Yi R,Scumpia P,Grigorian M,Lowry WE

更新日期：2014-01-01 00:00:00

abstract：:The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucle...

journal_title：Nature cell biology

authors： Selva EM,Hong K,Baeg GH,Beverley SM,Turco SJ,Perrimon N,Häcker U

更新日期：2001-09-01 00:00:00

abstract：:Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these processes are important in many cells, few factors that regulate spindle placement are known. Previous work has shown that GPB-1, the Gbeta subunit of a hetero...

journal_title：Nature cell biology

authors： Gotta M,Ahringer J

更新日期：2001-03-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are generated via the expression of the transcription factors OCT4 (also known as POU5F1), SOX2, KLF4 and cMYC (OSKM) in somatic cells. In contrast to murine naive iPSCs, conventional human iPSCs are in a more developmentally advanced state called primed pluripotency. Here, we re...

journal_title：Nature cell biology

authors： Giulitti S,Pellegrini M,Zorzan I,Martini P,Gagliano O,Mutarelli M,Ziller MJ,Cacchiarelli D,Romualdi C,Elvassore N,Martello G

更新日期：2019-02-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts ...

journal_title：Nature cell biology

authors： Shimoda M,Principe S,Jackson HW,Luga V,Fang H,Molyneux SD,Shao YW,Aiken A,Waterhouse PD,Karamboulas C,Hess FM,Ohtsuka T,Okada Y,Ailles L,Ludwig A,Wrana JL,Kislinger T,Khokha R

更新日期：2014-09-01 00:00:00

abstract：:Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative potential of normal cells that all cancer cells must bypass. Here we show by whole-genome single-nucleotide bi...

journal_title：Nature cell biology

authors： Cruickshanks HA,McBryan T,Nelson DM,Vanderkraats ND,Shah PP,van Tuyn J,Singh Rai T,Brock C,Donahue G,Dunican DS,Drotar ME,Meehan RR,Edwards JR,Berger SL,Adams PD

更新日期：2013-12-01 00:00:00

abstract：:In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent contraction of acto-myosin. In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo. Depletion of PDK1 alters th...

journal_title：Nature cell biology

authors： Pinner S,Sahai E

更新日期：2008-02-01 00:00:00

abstract：:Lamina-associated polypeptide (LAP) 2alpha is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2alpha and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin-LAP2alpha complex interacts with and regulates ret...

journal_title：Nature cell biology

authors： Naetar N,Korbei B,Kozlov S,Kerenyi MA,Dorner D,Kral R,Gotic I,Fuchs P,Cohen TV,Bittner R,Stewart CL,Foisner R

更新日期：2008-11-01 00:00:00

abstract：:Many classical biologists working in Antarctica have 'gone molecular' to study the physiological basis for life on or below the ice. Investigating the remarkable adaptations of specific cells, organelles and molecules to this extreme environment can provide new perspectives on the processes studied in conventional exp...

journal_title：Nature cell biology

authors： Römisch K,Matheson T

更新日期：2003-01-01 00:00:00

abstract：:The promyelocytic leukaemia (PML) tumour-suppressor protein potentiates p53 function by regulating post-translational modifications, such as CBP-dependent acetylation and Chk2-dependent phosphorylation, in the PML-Nuclear Body (NB). PML was recently shown to interact with the p53 ubiquitin-ligase Mdm2 (refs 4-6); howe...

journal_title：Nature cell biology

authors： Bernardi R,Scaglioni PP,Bergmann S,Horn HF,Vousden KH,Pandolfi PP

更新日期：2004-07-01 00:00:00

abstract：:Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damage...

journal_title：Nature cell biology

authors： van Tuyn J,Adams PD

更新日期：2012-04-02 00:00:00

abstract：:Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. ...

journal_title：Nature cell biology

authors： Yahara Y,Barrientos T,Tang YJ,Puviindran V,Nadesan P,Zhang H,Gibson JR,Gregory SG,Diao Y,Xiang Y,Qadri YJ,Souma T,Shinohara ML,Alman BA

更新日期：2020-01-01 00:00:00

abstract：:The mechanisms that control cell growth during the cell cycle are poorly understood. In budding yeast, cyclin dependent kinase 1 (Cdk1) triggers polarization of the actin cytoskeleton and bud emergence in late G1 through activation of the Cdc42 GTPase. However, Cdk1 is not thought to be required for subsequent growth ...

journal_title：Nature cell biology

authors： McCusker D,Denison C,Anderson S,Egelhofer TA,Yates JR 3rd,Gygi SP,Kellogg DR

更新日期：2007-05-01 00:00:00

abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...

journal_title：Nature cell biology

authors： Varga J,Greten FR

更新日期：2017-10-01 00:00:00

abstract：:Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assem...

journal_title：Nature cell biology

authors： Janiesch PC,Kim J,Mouysset J,Barikbin R,Lochmüller H,Cassata G,Krause S,Hoppe T

更新日期：2007-04-01 00:00:00

abstract：:Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...

journal_title：Nature cell biology

authors： Di Guglielmo GM,Le Roy C,Goodfellow AF,Wrana JL

更新日期：2003-05-01 00:00:00

abstract：:The mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this proton-motive force, the inner membrane forms a tight barrier and strictly controls the translocation of ions....

journal_title：Nature cell biology

authors： van der Laan M,Meinecke M,Dudek J,Hutu DP,Lind M,Perschil I,Guiard B,Wagner R,Pfanner N,Rehling P

更新日期：2007-10-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as E...

journal_title：Nature cell biology

authors： Takahashi Y,Coppola D,Matsushita N,Cualing HD,Sun M,Sato Y,Liang C,Jung JU,Cheng JQ,Mulé JJ,Pledger WJ,Wang HG

更新日期：2007-10-01 00:00:00

abstract：:Programmed cell death (apoptosis) is used by multicellular organisms during development and to maintain homeostasis within mature tissues. One of the first genes shown to regulate apoptosis was bcl-2. Subsequently, a number of Bcl-2-related proteins have been identified. Despite overwhelming evidence that Bcl-2 protei...

journal_title：Nature cell biology

authors： Vander Heiden MG,Thompson CB

更新日期：1999-12-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...

journal_title：Nature cell biology

authors： Floros VI,Pyle A,Dietmann S,Wei W,Tang WCW,Irie N,Payne B,Capalbo A,Noli L,Coxhead J,Hudson G,Crosier M,Strahl H,Khalaf Y,Saitou M,Ilic D,Surani MA,Chinnery PF

更新日期：2018-02-01 00:00:00