Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

abstract：:Guard cells, which form stomata in leaf epidermes, sense a multitude of environmental signals and integrate this information to regulate stomatal movements. Compared with the advanced understanding of light and water stress responses in guard cells, the molecular mechanisms that underlie stomatal CO(2) signalling have...

journal_title：Nature cell biology

authors： Hashimoto M,Negi J,Young J,Israelsson M,Schroeder JI,Iba K

更新日期：2006-04-01 00:00:00

abstract：:The metazoan nuclear pore complex (NPC) disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 sub-complex. We have found that Nup107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, ...

journal_title：Nature cell biology

authors： Mishra RK,Chakraborty P,Arnaoutov A,Fontoura BM,Dasso M

更新日期：2010-02-01 00:00:00

abstract：:YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...

journal_title：Nature cell biology

authors： Mo JS,Meng Z,Kim YC,Park HW,Hansen CG,Kim S,Lim DS,Guan KL

更新日期：2015-04-01 00:00:00

abstract：:In mammals, motile cilia cover many organs, such as fallopian tubes, respiratory tracts and brain ventricles. The development and function of these organs critically depend on efficient directional fluid flow ensured by the alignment of ciliary beating. To identify the mechanisms involved in this process, we analysed ...

journal_title：Nature cell biology

authors： Guirao B,Meunier A,Mortaud S,Aguilar A,Corsi JM,Strehl L,Hirota Y,Desoeuvre A,Boutin C,Han YG,Mirzadeh Z,Cremer H,Montcouquiol M,Sawamoto K,Spassky N

更新日期：2010-04-01 00:00:00

abstract：:The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane components. Here, simultaneous observations of quantum dot-labelled FcepsilonRI motion and GFP-tagged actin dynamics provide direct evidence that actin filament bundles define micron-sized domains that confine mobile receptors. Dyna...

journal_title：Nature cell biology

authors： Andrews NL,Lidke KA,Pfeiffer JR,Burns AR,Wilson BS,Oliver JM,Lidke DS

更新日期：2008-08-01 00:00:00

abstract：:Despite the presence of mutations in APC or beta-catenin, which are believed to activate the Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity when beta-catenin localization is analysed, indicating a more complex regulation of Wnt signalling. We explored this heterogeneity with...

journal_title：Nature cell biology

authors： Vermeulen L,De Sousa E Melo F,van der Heijden M,Cameron K,de Jong JH,Borovski T,Tuynman JB,Todaro M,Merz C,Rodermond H,Sprick MR,Kemper K,Richel DJ,Stassi G,Medema JP

更新日期：2010-05-01 00:00:00

abstract：:In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file. ...

journal_title：Nature cell biology

authors： Li L,Guo F,Gao Y,Ren Y,Yuan P,Yan L,Li R,Lian Y,Li J,Hu B,Gao J,Wen L,Tang F,Qiao J

更新日期：2018-10-01 00:00:00

abstract：:Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriche...

journal_title：Nature cell biology

authors： Phillips CM,Meng X,Zhang L,Chretien JH,Urnov FD,Dernburg AF

更新日期：2009-08-01 00:00:00

abstract：:Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...

journal_title：Nature cell biology

authors： Moreau V,Frischknecht F,Reckmann I,Vincentelli R,Rabut G,Stewart D,Way M

更新日期：2000-07-01 00:00:00

abstract：:The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show that Ran-GTP stimulates microtubule assembly by increasing the rescue frequency of microtubules three- to eightf...

journal_title：Nature cell biology

authors： Wilde A,Lizarraga SB,Zhang L,Wiese C,Gliksman NR,Walczak CE,Zheng Y

更新日期：2001-03-01 00:00:00

abstract：:The presence of actin in the nucleus has been well established, and several studies have implicated nuclear actin in transcriptional regulation. Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is a member of the WASP family of proteins; these proteins function in the cytoplasm as key regulators of cortical actin fi...

journal_title：Nature cell biology

authors： Wu X,Yoo Y,Okuhama NN,Tucker PW,Liu G,Guan JL

更新日期：2006-07-01 00:00:00

abstract：:The position of the mitotic spindle controls the plane of cell cleavage and determines whether polarized cells divide symmetrically or asymmetrically. In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and act...

journal_title：Nature cell biology

authors： Galli M,Muñoz J,Portegijs V,Boxem M,Grill SW,Heck AJ,van den Heuvel S

更新日期：2011-08-21 00:00:00

abstract：:Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, ...

journal_title：Nature cell biology

authors： Li F,Ackermann EJ,Bennett CF,Rothermel AL,Plescia J,Tognin S,Villa A,Marchisio PC,Altieri DC

更新日期：1999-12-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. ...

journal_title：Nature cell biology

authors： Kamura T,Hara T,Matsumoto M,Ishida N,Okumura F,Hatakeyama S,Yoshida M,Nakayama K,Nakayama KI

更新日期：2004-12-01 00:00:00

abstract：:During meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other. Here we show, by comparing the ...

journal_title：Nature cell biology

authors： Prieto P,Shaw P,Moore G

更新日期：2004-09-01 00:00:00

abstract：:Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet organogenesis and β...

journal_title：Nature cell biology

authors： Nair GG,Liu JS,Russ HA,Tran S,Saxton MS,Chen R,Juang C,Li ML,Nguyen VQ,Giacometti S,Puri S,Xing Y,Wang Y,Szot GL,Oberholzer J,Bhushan A,Hebrok M

更新日期：2019-02-01 00:00:00

abstract：:LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK...

journal_title：Nature cell biology

authors： Yang X,Yu K,Hao Y,Li DM,Stewart R,Insogna KL,Xu T

更新日期：2004-07-01 00:00:00

abstract：:Historically, the late arrival of optical microscopy is something of a puzzle, although it may be a testament to the fact that the development of new technology is driven by the desire for scientific knowledge, and not the other way around. The explorations that began in the 17th century are by no means complete, but ...

journal_title：Nature cell biology

authors： Amos B

更新日期：2000-08-01 00:00:00

abstract：:Re-establishment of nuclear structure and chromatin organization after cell division is integral for genome regulation or development and is frequently altered during cancer progression. The mechanisms underlying chromatin expansion in daughter cells remain largely unclear. Here, we describe the transient formation of...

journal_title：Nature cell biology

authors： Baarlink C,Plessner M,Sherrard A,Morita K,Misu S,Virant D,Kleinschnitz EM,Harniman R,Alibhai D,Baumeister S,Miyamoto K,Endesfelder U,Kaidi A,Grosse R

更新日期：2017-12-01 00:00:00

abstract：:For accurate segregation of chromosomes during cell division, microtubule fibres must attach sister kinetochores to opposite poles of the mitotic spindle (bi-orientation). Aurora kinases are linked to oncogenesis and have been implicated in the regulation of chromosome-microtubule attachments. Although loss of Aurora ...

journal_title：Nature cell biology

authors： Lampson MA,Renduchitala K,Khodjakov A,Kapoor TM

更新日期：2004-03-01 00:00:00

abstract：:Science denial is not new but, in the digital age, evidence-based conclusions appear to be increasingly threatened by beliefs based on emotion and isolated personal experience. When confronting a post-truth world, scientists must defend the scientific method and increase public engagement. ...

journal_title：Nature cell biology

authors：

更新日期：2018-11-01 00:00:00

abstract：:The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with...

journal_title：Nature cell biology

authors： Farassati F,Yang AD,Lee PW

更新日期：2001-08-01 00:00:00

abstract：:SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11. Actively importing cystine is potentially toxic due to its low solubility, forcing cancer cells with high levels of SLC7A11 (SLC7...

journal_title：Nature cell biology

authors： Liu X,Olszewski K,Zhang Y,Lim EW,Shi J,Zhang X,Zhang J,Lee H,Koppula P,Lei G,Zhuang L,You MJ,Fang B,Li W,Metallo CM,Poyurovsky MV,Gan B

更新日期：2020-04-01 00:00:00

abstract：:The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...

journal_title：Nature cell biology

authors： Moisan A,Lee YK,Zhang JD,Hudak CS,Meyer CA,Prummer M,Zoffmann S,Truong HH,Ebeling M,Kiialainen A,Gérard R,Xia F,Schinzel RT,Amrein KE,Cowan CA

更新日期：2015-01-01 00:00:00

abstract：:Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process,...

journal_title：Nature cell biology

authors： Hatch EM

更新日期：2016-12-23 00:00:00

abstract：:Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...

journal_title：Nature cell biology

authors： Bement WM,Leda M,Moe AM,Kita AM,Larson ME,Golding AE,Pfeuti C,Su KC,Miller AL,Goryachev AB,von Dassow G

更新日期：2015-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...

journal_title：Nature cell biology

authors： Holcman D,Parutto P,Chambers JE,Fantham M,Young LJ,Marciniak SJ,Kaminski CF,Ron D,Avezov E

更新日期：2018-10-01 00:00:00

abstract：:Although myosin II filaments are known to exist in non-muscle cells, their dynamics and organization are incompletely understood. Here, we combined structured illumination microscopy with pharmacological and genetic perturbations, to study the process of actomyosin cytoskeleton self-organization into arcs and stress f...

journal_title：Nature cell biology

authors： Hu S,Dasbiswas K,Guo Z,Tee YH,Thiagarajan V,Hersen P,Chew TL,Safran SA,Zaidel-Bar R,Bershadsky AD

更新日期：2017-02-01 00:00:00

abstract：:Gastrulation leads to three germ layers--ectoderm, mesoderm and endoderm--that are separated by two basement membranes. In the mouse embryo, the emergent gut endoderm results from the widespread intercalation of cells of two distinct origins: pluripotent epiblast-derived definitive endoderm (DE) and extra-embryonic vi...

journal_title：Nature cell biology

authors： Viotti M,Nowotschin S,Hadjantonakis AK

更新日期：2014-12-01 00:00:00

abstract：:Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesin loading onto chro...

journal_title：Nature cell biology

authors： Nasmyth K

更新日期：2011-10-03 00:00:00