p53 mutations promote proteasomal activity.

abstract：:Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a protein kinase, DYRK2, has unexpected role as a scaffold for an E3 ubiquitin ligase complex. DYRK2 associates with an E3 ligase complex containing EDD, DDB1 and VPRBP pro...

journal_title：Nature cell biology

authors： Maddika S,Chen J

更新日期：2009-04-01 00:00:00

abstract：:Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assem...

journal_title：Nature cell biology

authors： Janiesch PC,Kim J,Mouysset J,Barikbin R,Lochmüller H,Cassata G,Krause S,Hoppe T

更新日期：2007-04-01 00:00:00

abstract：:Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and ...

journal_title：Nature cell biology

authors： Chan GK,Jablonski SA,Starr DA,Goldberg ML,Yen TJ

更新日期：2000-12-01 00:00:00

abstract：:The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particu...

journal_title：Nature cell biology

authors： Tognetti S,Speck C

更新日期：2016-05-27 00:00:00

abstract：:Reference datasets should be accessible independently of scientific papers in a citable form, allowing attribution. ...

journal_title：Nature cell biology

authors：

更新日期：2009-11-01 00:00:00

abstract：:NF-kappa B/Rel transcription factors control apoptosis, also known as programmed cell death. This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing tumour necrosis factor alpha (TNFalpha)-induced killing. With regard to TNFalpha, the anti-apoptotic activity of NF-kappa B involves suppres...

journal_title：Nature cell biology

authors： Papa S,Zazzeroni F,Bubici C,Jayawardena S,Alvarez K,Matsuda S,Nguyen DU,Pham CG,Nelsbach AH,Melis T,De Smaele E,Tang WJ,D'Adamio L,Franzoso G

更新日期：2004-02-01 00:00:00

abstract：:Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external...

journal_title：Nature cell biology

authors： Celià-Terrassa T,Kang Y

更新日期：2018-08-01 00:00:00

abstract：:Telomere attrition and other forms of telomere damage can activate the ATM kinase pathway. What generates the DNA damage signal at mammalian chromosome ends or at other double-strand breaks is not known. Telomere dysfunction is often accompanied by disappearance of the 3' telomeric overhang, raising the possibility th...

journal_title：Nature cell biology

authors： Celli GB,de Lange T

更新日期：2005-07-01 00:00:00

abstract：:Protein ubiquitination regulates many cellular processes, including protein degradation, signal transduction, DNA repair and cell division. In the classical model, a uniform polyubiquitin chain that is linked through Lys 48 is required for recognition and degradation by the 26S proteasome. Here, we used a reconstitute...

journal_title：Nature cell biology

authors： Kirkpatrick DS,Hathaway NA,Hanna J,Elsasser S,Rush J,Finley D,King RW,Gygi SP

更新日期：2006-07-01 00:00:00

abstract：:Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG ...

journal_title：Nature cell biology

authors： Nakamura S,Shigeyama S,Minami S,Shima T,Akayama S,Matsuda T,Esposito A,Napolitano G,Kuma A,Namba-Hamano T,Nakamura J,Yamamoto K,Sasai M,Tokumura A,Miyamoto M,Oe Y,Fujita T,Terawaki S,Takahashi A,Hamasaki M,Yamamot

更新日期：2020-10-01 00:00:00

abstract：:Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. ...

journal_title：Nature cell biology

authors： Livesey FJ

更新日期：2012-10-01 00:00:00

abstract：:During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and daughter centriole. This linker is disassembled at the onset of mitosis in a process known as centrosome disjunction, thereby facilitating centrosome separation and bipolar spindle formation. Th...

journal_title：Nature cell biology

authors： Mardin BR,Lange C,Baxter JE,Hardy T,Scholz SR,Fry AM,Schiebel E

更新日期：2010-12-01 00:00:00

abstract：:MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endo...

journal_title：Nature cell biology

authors： Kotlyarov A,Neininger A,Schubert C,Eckert R,Birchmeier C,Volk HD,Gaestel M

更新日期：1999-06-01 00:00:00

abstract：:Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damage...

journal_title：Nature cell biology

authors： van Tuyn J,Adams PD

更新日期：2012-04-02 00:00:00

abstract：:We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics. We show that Rab10 localizes to the ER and to dynamic ER-associated structures that track along microtubules and mark the position of new ER tubule growth. Rab10 depletion or expression of a Rab10 GDP-locked mutant alters E...

journal_title：Nature cell biology

authors： English AR,Voeltz GK

更新日期：2013-02-01 00:00:00

abstract：:When co-translationally inserted into endoplasmic reticulum (ER) membranes, newly synthesized proteins encounter the lumenal environment of the ER, which contains chaperone proteins that facilitate the folding reactions necessary for protein oligomerization, maturation and export from the ER. Here we show, using a tem...

journal_title：Nature cell biology

authors： Nehls S,Snapp EL,Cole NB,Zaal KJ,Kenworthy AK,Roberts TH,Ellenberg J,Presley JF,Siggia E,Lippincott-Schwartz J

更新日期：2000-05-01 00:00:00

abstract：:Rad23 is a nucleotide-excision repair protein with a previously unknown biochemical function. We determined that yeast and human Rad23 inhibited multi-ubiquitin (Ub) chain formation and the degradation of proteolytic substrates. Significantly, Rad23 could be co-precipitated with a substrate that contained a short mult...

journal_title：Nature cell biology

authors： Ortolan TG,Tongaonkar P,Lambertson D,Chen L,Schauber C,Madura K

更新日期：2000-09-01 00:00:00

abstract：:RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...

journal_title：Nature cell biology

authors： Fellmann C,Lowe SW

更新日期：2014-01-01 00:00:00

abstract：:Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of the molecular mechanisms by which adhesion disassembly is regulated, including the contributions of adhesion adaptor proteins...

journal_title：Nature cell biology

authors： Franco SJ,Rodgers MA,Perrin BJ,Han J,Bennin DA,Critchley DR,Huttenlocher A

更新日期：2004-10-01 00:00:00

abstract：:In some organs, adult stem cells are uniquely poised to serve as cancer cells of origin. It is unclear, however, whether tumorigenesis is influenced by the activation state of the adult stem cell. Hair follicle stem cells (HFSCs) act as cancer cells of origin for cutaneous squamous cell carcinoma and undergo defined c...

journal_title：Nature cell biology

authors： White AC,Khuu JK,Dang CY,Hu J,Tran KV,Liu A,Gomez S,Zhang Z,Yi R,Scumpia P,Grigorian M,Lowry WE

更新日期：2014-01-01 00:00:00

abstract：:Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiqu...

journal_title：Nature cell biology

authors： Meerang M,Ritz D,Paliwal S,Garajova Z,Bosshard M,Mailand N,Janscak P,Hübscher U,Meyer H,Ramadan K

更新日期：2011-10-23 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but how they arise is not clear1,2. Here we show that mtDNA mutations are present in primordial germ cells (PGCs) within healthy female human embryos. Isolated PGCs have a profound reduct...

journal_title：Nature cell biology

authors： Floros VI,Pyle A,Dietmann S,Wei W,Tang WCW,Irie N,Payne B,Capalbo A,Noli L,Coxhead J,Hudson G,Crosier M,Strahl H,Khalaf Y,Saitou M,Ilic D,Surani MA,Chinnery PF

更新日期：2018-02-01 00:00:00

abstract：:Here we evaluate the idea that the Golgi is in dynamic equilibrium with the endoplasmic reticulum (ER). In cytoplasts that lack the Golgi apparatus, no regrowth of the Golgi is observed, nor is any transport from the ER to the cell surface detected. However, introduction of the smallest measurable amount of Golgi (equ...

journal_title：Nature cell biology

authors： Pelletier L,Jokitalo E,Warren G

更新日期：2000-11-01 00:00:00

abstract：:Plant cell morphogenesis relies on the organization and function of two polymer arrays separated by the plasma membrane: the cortical microtubule cytoskeleton and cellulose microfibrils in the cell wall. Studies using in vivo markers confirmed that one function of the cortical microtubule array is to drive organizatio...

journal_title：Nature cell biology

authors： Gutierrez R,Lindeboom JJ,Paredez AR,Emons AM,Ehrhardt DW

更新日期：2009-07-01 00:00:00

abstract：:Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin funct...

journal_title：Nature cell biology

authors： Evangelista M,Pruyne D,Amberg DC,Boone C,Bretscher A

更新日期：2002-01-01 00:00:00

abstract：:Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dep...

journal_title：Nature cell biology

authors： Krek W

更新日期：2000-07-01 00:00:00

abstract：:The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increas...

journal_title：Nature cell biology

authors： Mohammadi H,Sahai E

更新日期：2018-07-01 00:00:00

abstract：:Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show that GALA induces th...

journal_title：Nature cell biology

authors： Ros M,Nguyen AT,Chia J,Le Tran S,Le Guezennec X,McDowall R,Vakhrushev S,Clausen H,Humphries MJ,Saltel F,Bard FA

更新日期：2020-11-01 00:00:00

abstract：:Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H(2)O(2)) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not be...

journal_title：Nature cell biology

authors： Klamt F,Zdanov S,Levine RL,Pariser A,Zhang Y,Zhang B,Yu LR,Veenstra TD,Shacter E

更新日期：2009-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...

journal_title：Nature cell biology

authors： Mavrakis KJ,Wolfe AL,Oricchio E,Palomero T,de Keersmaecker K,McJunkin K,Zuber J,James T,Khan AA,Leslie CS,Parker JS,Paddison PJ,Tam W,Ferrando A,Wendel HG

更新日期：2010-04-01 00:00:00