Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.

abstract：:The retinoblastoma protein (pRB) negatively regulates the progression from G1 to S phase of the cell cycle, in part, by repressing E2F-dependent transcription. pRB also possesses E2F-independent functions that contribute to cell-cycle control--for example, during pRB-mediated cell-cycle arrest pRB associates with Skp2...

journal_title：Nature cell biology

authors： Binné UK,Classon MK,Dick FA,Wei W,Rape M,Kaelin WG Jr,Näär AM,Dyson NJ

更新日期：2007-02-01 00:00:00

abstract：:Formation of a bipolar spindle is essential for faithful chromosome segregation at mitosis. Because centrosomes define spindle poles, defects in centrosome number and structural organization can lead to a loss of bipolarity. In addition, microtubule-mediated pulling and pushing forces acting on centrosomes and chromos...

journal_title：Nature cell biology

authors： Oshimori N,Ohsugi M,Yamamoto T

更新日期：2006-10-01 00:00:00

abstract：:The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain...

journal_title：Nature cell biology

authors： Holcman D,Parutto P,Chambers JE,Fantham M,Young LJ,Marciniak SJ,Kaminski CF,Ron D,Avezov E

更新日期：2018-10-01 00:00:00

abstract：:RNA interference has become an indispensable tool for loss-of-function studies across eukaryotes. By enabling stable and reversible gene silencing, shRNAs provide a means to study long-term phenotypes, perform pool-based forward genetic screens and examine the consequences of temporary target inhibition in vivo. Howev...

journal_title：Nature cell biology

authors： Fellmann C,Lowe SW

更新日期：2014-01-01 00:00:00

abstract：:Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remains to be resolved whether Topo II has any role in checkpoint control. Here we report that when phosphorylated, Ser 1524 of Topo IIalpha acts as a binding site for the BR...

journal_title：Nature cell biology

authors： Luo K,Yuan J,Chen J,Lou Z

更新日期：2009-02-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. Th...

journal_title：Nature cell biology

authors： Labernadie A,Kato T,Brugués A,Serra-Picamal X,Derzsi S,Arwert E,Weston A,González-Tarragó V,Elosegui-Artola A,Albertazzi L,Alcaraz J,Roca-Cusachs P,Sahai E,Trepat X

更新日期：2017-03-01 00:00:00

abstract：:Collective cell migration occurs in a range of contexts: cancer cells frequently invade in cohorts while retaining cell-cell junctions. Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact. When actomyosin is not downregulated at cell-cell c...

journal_title：Nature cell biology

authors： Hidalgo-Carcedo C,Hooper S,Chaudhry SI,Williamson P,Harrington K,Leitinger B,Sahai E

更新日期：2011-01-01 00:00:00

abstract：:Repulsive guidance molecule (RGM) is a recently identified protein implicated in both axonal guidance and neural tube closure. The avoidance of chick RGM in the posterior optic tectum by growing temporal, but not nasal, retinal ganglion cell axons is thought to contribute to visual map formation. In contrast to ephrin...

journal_title：Nature cell biology

authors： Rajagopalan S,Deitinghoff L,Davis D,Conrad S,Skutella T,Chedotal A,Mueller BK,Strittmatter SM

更新日期：2004-08-01 00:00:00

abstract：:We describe a genome-wide gain-of-function screen for regulators of NF-kappaB, and identify Rap1 (Trf2IP), as an essential modulator of NF-kappaB-mediated pathways. NF-kappaB is induced by ectopic expression of Rap1, whereas its activity is inhibited by Rap1 depletion. In addition to localizing on telomeres, mammalian...

journal_title：Nature cell biology

authors： Teo H,Ghosh S,Luesch H,Ghosh A,Wong ET,Malik N,Orth A,de Jesus P,Perry AS,Oliver JD,Tran NL,Speiser LJ,Wong M,Saez E,Schultz P,Chanda SK,Verma IM,Tergaonkar V

更新日期：2010-08-01 00:00:00

abstract：:When co-translationally inserted into endoplasmic reticulum (ER) membranes, newly synthesized proteins encounter the lumenal environment of the ER, which contains chaperone proteins that facilitate the folding reactions necessary for protein oligomerization, maturation and export from the ER. Here we show, using a tem...

journal_title：Nature cell biology

authors： Nehls S,Snapp EL,Cole NB,Zaal KJ,Kenworthy AK,Roberts TH,Ellenberg J,Presley JF,Siggia E,Lippincott-Schwartz J

更新日期：2000-05-01 00:00:00

abstract：:Tumour growth and invasiveness require extracellular matrix (ECM) degradation and are stimulated by the GALA pathway, which induces protein O-glycosylation in the endoplasmic reticulum (ER). ECM degradation requires metalloproteases, but whether other enzymes are required is unclear. Here, we show that GALA induces th...

journal_title：Nature cell biology

authors： Ros M,Nguyen AT,Chia J,Le Tran S,Le Guezennec X,McDowall R,Vakhrushev S,Clausen H,Humphries MJ,Saltel F,Bard FA

更新日期：2020-11-01 00:00:00

abstract：:The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process. However, the signalling components involved in such rapid Ca(2+) movement are not fully understood. Here we report that mice deficient in the newly identified PtdInsP...

journal_title：Nature cell biology

authors： Shen J,Yu WM,Brotto M,Scherman JA,Guo C,Stoddard C,Nosek TM,Valdivia HH,Qu CK

更新日期：2009-06-01 00:00:00

abstract：:Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here w...

journal_title：Nature cell biology

authors： Di Guglielmo GM,Le Roy C,Goodfellow AF,Wrana JL

更新日期：2003-05-01 00:00:00

abstract：:Stereocilia are microvilli-derived mechanosensory organelles that are arranged in rows of graded heights on the apical surface of inner-ear hair cells. The 'staircase'-like architecture of stereocilia bundles is necessary to detect sound and head movement, and is achieved through differential elongation of the actin c...

journal_title：Nature cell biology

authors： Belyantseva IA,Boger ET,Naz S,Frolenkov GI,Sellers JR,Ahmed ZM,Griffith AJ,Friedman TB

更新日期：2005-02-01 00:00:00

abstract：:The position of the mitotic spindle controls the plane of cell cleavage and determines whether polarized cells divide symmetrically or asymmetrically. In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and act...

journal_title：Nature cell biology

authors： Galli M,Muñoz J,Portegijs V,Boxem M,Grill SW,Heck AJ,van den Heuvel S

更新日期：2011-08-21 00:00:00

abstract：:Historically, the late arrival of optical microscopy is something of a puzzle, although it may be a testament to the fact that the development of new technology is driven by the desire for scientific knowledge, and not the other way around. The explorations that began in the 17th century are by no means complete, but ...

journal_title：Nature cell biology

authors： Amos B

更新日期：2000-08-01 00:00:00

abstract：:Adenomatous polyposis coli protein (APC) is an important tumour suppressor in the human colon epithelium. In a complex with glycogen synthase kinase-3 (GSK-3), APC binds to and destabilizes cytoplasmic ('free') beta-catenin. Here, using a yeast two-hybrid screen for proteins that bind to the Drosophila beta-catenin ho...

journal_title：Nature cell biology

authors： Yu X,Waltzer L,Bienz M

更新日期：1999-07-01 00:00:00

abstract：:Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic mark that specifies centromere identity. Here we identify the essential centromere...

journal_title：Nature cell biology

authors： Carroll CW,Silva MC,Godek KM,Jansen LE,Straight AF

更新日期：2009-07-01 00:00:00

abstract：:YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumour suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression ...

journal_title：Nature cell biology

authors： Mo JS,Meng Z,Kim YC,Park HW,Hansen CG,Kim S,Lim DS,Guan KL

更新日期：2015-04-01 00:00:00

abstract：:Influx of Ca(2+) through store-operated Ca(2+) channels (SOCs) is a central component of receptor-evoked Ca(2+) signals. Orai channels are SOCs that are gated by STIM1, a Ca(2+) sensor located in the ER but how it gates and regulates the Orai channels is unknown. Here, we report the molecular basis for gating of Orais...

journal_title：Nature cell biology

authors： Yuan JP,Zeng W,Dorwart MR,Choi YJ,Worley PF,Muallem S

更新日期：2009-03-01 00:00:00

abstract：:Different sites of plasma membrane attachment may underlie functional differences between isoforms of Ras. Here we show that palmitoylation and farnesylation targets H-ras to lipid rafts and caveolae, but that the interaction of H-ras with these membrane subdomains is dynamic. GTP-loading redistributes H-ras from raft...

journal_title：Nature cell biology

authors： Prior IA,Harding A,Yan J,Sluimer J,Parton RG,Hancock JF

更新日期：2001-04-01 00:00:00

abstract：:The metazoan nuclear pore complex (NPC) disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 sub-complex. We have found that Nup107-160 interacts with the gamma-tubulin ring complex (gamma-TuRC), an essential and conserved microtubule nucleator, ...

journal_title：Nature cell biology

authors： Mishra RK,Chakraborty P,Arnaoutov A,Fontoura BM,Dasso M

更新日期：2010-02-01 00:00:00

abstract：:TP53 (tumour protein 53) is one of the most frequently mutated genes in human cancer and its role during cellular transformation has been studied extensively. However, the homeostatic functions of p53 are less well understood. Here, we explore the molecular dependency network of TP53 through an RNAi-mediated synthetic...

journal_title：Nature cell biology

authors： Krastev DB,Slabicki M,Paszkowski-Rogacz M,Hubner NC,Junqueira M,Shevchenko A,Mann M,Neugebauer KM,Buchholz F

更新日期：2011-06-05 00:00:00

abstract：:Guard cells, which form stomata in leaf epidermes, sense a multitude of environmental signals and integrate this information to regulate stomatal movements. Compared with the advanced understanding of light and water stress responses in guard cells, the molecular mechanisms that underlie stomatal CO(2) signalling have...

journal_title：Nature cell biology

authors： Hashimoto M,Negi J,Young J,Israelsson M,Schroeder JI,Iba K

更新日期：2006-04-01 00:00:00

abstract：:To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire chromosomes are copied remains a major challenge. Here, we use nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human...

journal_title：Nature cell biology

authors： Alabert C,Bukowski-Wills JC,Lee SB,Kustatscher G,Nakamura K,de Lima Alves F,Menard P,Mejlvang J,Rappsilber J,Groth A

更新日期：2014-03-01 00:00:00

abstract：:Actin and myosin are major components of the cell cytoskeleton, with structural and regulatory functions that affect many essential cellular processes. Although they were traditionally thought to function only in the cytoplasm, it is now well accepted that actin and multiple myosins are found in the nucleus. Increasin...

journal_title：Nature cell biology

authors： de Lanerolle P,Serebryannyy L

更新日期：2011-11-02 00:00:00

abstract：:The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been shown to prevent diet-i...

journal_title：Nature cell biology

authors： Moisan A,Lee YK,Zhang JD,Hudak CS,Meyer CA,Prummer M,Zoffmann S,Truong HH,Ebeling M,Kiialainen A,Gérard R,Xia F,Schinzel RT,Amrein KE,Cowan CA

更新日期：2015-01-01 00:00:00

abstract：:The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports...

journal_title：Nature cell biology

authors： Lüders J

更新日期：2012-11-01 00:00:00

abstract：:Focal adhesions are integrin-based multiprotein complexes, several micrometres in diameter, that mechanically link the extracellular matrix with the termini of actin bundles. The molecular diversity of focal adhesions and their role in cell migration and matrix sensing has been extensively studied, but their ultrastru...

journal_title：Nature cell biology

authors： Patla I,Volberg T,Elad N,Hirschfeld-Warneken V,Grashoff C,Fässler R,Spatz JP,Geiger B,Medalia O

更新日期：2010-09-01 00:00:00

abstract：:Apoptosis is induced by caspases, which are members of the cysteine protease family. Caspases are synthesized as inactive zymogens and initiator caspases first gain activity by associating with an oligomeric complex of their adaptor proteins, such as the apoptosome. Activated initiator caspases subsequently cleave and...

journal_title：Nature cell biology

authors： Shapiro PJ,Hsu HH,Jung H,Robbins ES,Ryoo HD

更新日期：2008-12-01 00:00:00