Abstract：
:Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy. Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation, but this process was independent of the transcriptional activity of FoxO1. In response to stress, FoxO1 was acetylated by dissociation from sirtuin-2 (SIRT2), a NAD(+)-dependent histone deacetylase, and the acetylated FoxO1 bound to Atg7, an E1-like protein, to influence the autophagic process leading to cell death. This FoxO1-modulated cell death is associated with tumour suppressor activity in human colon tumours and a xenograft mouse model. Our finding links the anti-neoplastic activity of FoxO1 and the process of autophagy.
journal_name
Nat Cell Bioljournal_title
Nature cell biologyauthors
Zhao Y,Yang J,Liao W,Liu X,Zhang H,Wang S,Wang D,Feng J,Yu L,Zhu WGdoi
10.1038/ncb2069subject
Has Abstractpub_date
2010-07-01 00:00:00pages
665-75issue
7eissn
1465-7392issn
1476-4679pii
ncb2069journal_volume
12pub_type
杂志文章abstract：:Protein degradation in eukaryotes often requires the ubiquitin-selective chaperone p97 for substrate recruitment and ubiquitin-chain assembly. However, the physiological relevance of p97, and its role in developmental processes, remain unclear. Here, we discover an unanticipated function for CDC-48/p97 in myosin assem...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1554
更新日期：2007-04-01 00:00:00
abstract：:The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by secreting soluble factors that promote tumorigenesis. Here we identify a feedforward mechanism in which endothelial cells (ECs), in response to tumour-derived mediators, release angiocrines dri...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2954
更新日期：2014-05-01 00:00:00
abstract：:The transition from cellular quiescence (G0) into S phase is regulated by the mitogenic-activation of D-type cyclins and cyclin-dependent kinases (Cdks), the sequestration of the Cdk inhibitors (CDKIs), p21 and p27, and the hyperphosphorylation of Rb with release of E2F transcription factors. However, fibroblasts that...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1548
更新日期：2007-03-01 00:00:00
abstract：:Understanding the factors that direct tissue organization during development is one of the most fundamental goals in developmental biology. Various hypotheses explain cell sorting and tissue organization on the basis of the adhesive and mechanical properties of the constituent cells. However, validating these hypothes...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1705
更新日期：2008-04-01 00:00:00
abstract：:MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17-92 cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo. Clinical use of these findings hinges on isolating the oncogenic activity within the 17-92 cluster and defin...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2037
更新日期：2010-04-01 00:00:00
abstract：:The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/ncb3611
更新日期：2017-10-01 00:00:00
abstract：:Chaperone proteins are thought to promote the correct folding and assembly of newly synthesized proteins and to facilitate restoration of the folded state under environmental conditions that favour protein denaturation. They are among the most ubiquitous and highly conserved of all proteins. The eukaryotic endoplasmic...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1001-891
更新日期：2001-10-01 00:00:00
abstract：:Re-establishment of nuclear structure and chromatin organization after cell division is integral for genome regulation or development and is frequently altered during cancer progression. The mechanisms underlying chromatin expansion in daughter cells remain largely unclear. Here, we describe the transient formation of...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3641
更新日期：2017-12-01 00:00:00
abstract：:Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-indepe...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35017080
更新日期：2000-07-01 00:00:00
abstract：:Symmetrical cell division requires duplication of DNA and protein content to generate two daughter cells. Centrosomes also duplicate during cell division, but the mechanism controlling this process is incompletely understood. We describe an alternative splice form of SadB encoding a short SADB Ser/Thr kinase whose act...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1921
更新日期：2009-09-01 00:00:00
abstract：:Lingual keratinized epithelial cells, which constitute the filiform papillae of the tongue, have one of the most rapid tissue turnover rates in the mammalian body and are thought to be the source of squamous cell carcinoma of the tongue. However, the mechanism of tissue maintenance and regeneration is largely unknown ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2719
更新日期：2013-05-01 00:00:00
abstract：:Endoplasmic reticulum (ER)-associated protein degradation by the ubiquitin-proteasome system requires the dislocation of substrates from the ER into the cytosol. It has been speculated that a functional ubiquitin proteasome pathway is not only essential for proteolysis, but also for the preceding export step. Here, we...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb746
更新日期：2002-02-01 00:00:00
abstract：:Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubic...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb3197
更新日期：2015-07-01 00:00:00
abstract：:The actin filament (F-actin) cytoskeleton associates dynamically with the plasma membrane and is thus ideally positioned to participate in endocytosis. Indeed, a wealth of genetic and biochemical evidence has confirmed that actin interacts with components of the endocytic machinery, although its precise function in en...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1025
更新日期：2003-08-01 00:00:00
abstract：:Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive response to cellular hypoxia is HIF (hypoxia-inducible factor), a transcription factor that activates an array of genes impli...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1144
更新日期：2004-07-01 00:00:00
abstract：:Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb3059
更新日期：2014-11-01 00:00:00
abstract：:In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2294
更新日期：2011-07-17 00:00:00
abstract：:Stereocilia are microvilli-derived mechanosensory organelles that are arranged in rows of graded heights on the apical surface of inner-ear hair cells. The 'staircase'-like architecture of stereocilia bundles is necessary to detect sound and head movement, and is achieved through differential elongation of the actin c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1219
更新日期：2005-02-01 00:00:00
abstract：:Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is responsive to signals from the spindle. We show that shortly after a...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3251
更新日期：2015-11-01 00:00:00
abstract：:The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient c...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3415
更新日期：2016-11-01 00:00:00
abstract：:Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin d...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3390
更新日期：2016-08-01 00:00:00
abstract：: ...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/s41556-018-0246-5
更新日期：2018-12-01 00:00:00
abstract：:The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particu...
journal_title：Nature cell biology
pub_type： 评论,杂志文章
doi：10.1038/ncb3367
更新日期：2016-05-27 00:00:00
abstract：:The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and functions remains ...
journal_title：Nature cell biology
pub_type： 杂志文章,评审
doi：10.1038/s41556-018-0250-9
更新日期：2019-01-01 00:00:00
abstract：:Chromatin structure is thought to play a critical role in gene expression. Using the lac operator/repressor system and two colour variants of green fluorescent protein (GFP), we developed a system to visualize a gene and its protein product directly in living cells, allowing us to examine the spatial organization and ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/35046510
更新日期：2000-12-01 00:00:00
abstract：:The actin cable is a supracellular structure that embryonic epithelia produce to close gaps. However, the action of the cable remains debated. Here, we address the function of the cable using Drosophila dorsal closure, a paradigm to understand wound healing. First, we show that the actin cytoskeleton protein Zasp52 is...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb3421
更新日期：2016-11-01 00:00:00
abstract：:In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent contraction of acto-myosin. In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo. Depletion of PDK1 alters th...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1675
更新日期：2008-02-01 00:00:00
abstract：:Growing microtubule end regions recruit a variety of proteins collectively termed +TIPs, which confer local functions to the microtubule cytoskeleton. +TIPs form dynamic interaction networks whose behaviour depends on a number of potentially competitive and hierarchical interaction modes. The rules that determine whic...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2999
更新日期：2014-08-01 00:00:00
abstract：:Proteins essential for vesicle formation by the Coat Protein I (COPI) complex are being identified, but less is known about the role of specific lipids. Brefeldin-A ADP-ribosylated substrate (BARS) functions in the fission step of COPI vesicle formation. Here, we show that BARS induces membrane curvature in cooperatio...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb1774
更新日期：2008-10-01 00:00:00
abstract：:Metazoan internal organs are assembled from polarized tubular epithelia that must set aside an apical membrane domain as a lumenal surface. In a global Caenorhabditis elegans tubulogenesis screen, interference with several distinct fatty-acid-biosynthetic enzymes transformed a contiguous central intestinal lumen into ...
journal_title：Nature cell biology
pub_type： 杂志文章
doi：10.1038/ncb2328
更新日期：2011-09-18 00:00:00
