abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyperproliferation and excessive inflammatory response are considered to be potentially useful for pso...

journal_title：Biological research

authors： Gao J,Chen F,Fang H,Mi J,Qi Q,Yang M

更新日期：2020-10-20 00:00:00

abstract：:Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. T...

journal_title：Biological research

authors： Yang Y,Yujiao W,Fang W,Linhui Y,Ziqi G,Zhichen W,Zirui W,Shengwang W

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS:A total of 15 differential...

journal_title：Biological research

authors： Wei X,Zhang Y,Yang Z,Sha Y,Pan Y,Chen Y,Cai L

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Previous studies have shown that long noncoding RNA (lncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this lncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC00483 on gastric can...

journal_title：Biological research

authors： Luo M,Liang C

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Papillary thyroid cancer (PTC) is the most common malignancy of all thyroid cancers. LncRNA LINC00460 has been proved to play roles in the oncogenesis and progression of various tumors, including papillary thyroid cancer. However, the potential molecular mechanism of LINC00460 in PTC is poorly investigated. ...

journal_title：Biological research

authors： Li G,Kong Q

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:IcarisideII (ICAII) could promote the differentiation of adipose tissue-derived stem cells (ADSCs) to Schwann cells (SCs), leading to improvement of erectile function (EF) and providing a realistic therapeutic option for the treatment of erectile dysfunction (ED). However, the underlying molecular mechanisms...

journal_title：Biological research

authors： Ge P,Guo Y,Shen J

更新日期：2019-10-03 00:00:00

abstract：BACKGROUND:Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to identify patients at risk of poor prognoses. METHODS:Tissue microarrays were used to measure expressio...

journal_title：Biological research

authors： Li W,Chen Y,Sun X,Yang J,Zhang DY,Wang D,Suo J

更新日期：2019-08-09 00:00:00

abstract：BACKGROUND:Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerati...

journal_title：Biological research

authors： Wang X,Peng P,Pan Z,Fang Z,Lu W,Liu X

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-...

journal_title：Biological research

authors： Wei H,Lin L,Zhang X,Feng Z,Wang Y,You Y,Wang X,Hou Y

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart ...

journal_title：Biological research

authors： Alcayaga J,Del Rio R,Moya EA,Freire M,Iturriaga R

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:Accumulating studies have demonstrated that high-mobility group A2 (HMGA2), an oncofetal protein, plays a role in tumor development and progression. However, the molecular role of HMGA2 in ovarian carcinoma is yet to be established. MicroRNAs (miRNAs), a group of small noncoding RNAs, negatively regulate gen...

journal_title：Biological research

authors： Xing F,Song Z,He Y

更新日期：2018-11-24 00:00:00

abstract：BACKGROUND:miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown. METHODS:In this study, an I/R-induced...

journal_title：Biological research

authors： Zhu X,Li W,Li H

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive with poor prognosis. Long non-coding RNAs (lncRNAs), a group of non-coding RNAs, play important roles in the progression of PDAC. This study aimed to investigate the potential involvement of lncRNA CCAT2 in PDAC tumorigenesis. METHODS:Expression o...

journal_title：Biological research

authors： Cai Y,Li X,Shen P,Zhang D

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells and develop therapeutic treatments for bone- or adipose-related diseases. In this study, the role of R...

journal_title：Biological research

authors： Madrigal A,Tan L,Zhao Y

更新日期：2017-12-26 00:00:00

abstract：BACKGROUND:Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been defined as an anti-cancer a...

journal_title：Biological research

authors： Du M,Zhang Z,Gao T

更新日期：2017-10-17 00:00:00

abstract：BACKGROUND:CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived CCL2 on microglia activation in vitro. METHODS:The rats were pretreated with CCL2 receptor inhibit...

journal_title：Biological research

authors： Zhang L,Tan J,Jiang X,Qian W,Yang T,Sun X,Chen Z,Zhu Q

更新日期：2017-09-04 00:00:00

abstract：BACKGROUND:Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS:The mRNA and DNA copies of USP39 ...

journal_title：Biological research

authors： Gan Z,Han K,Lin S,Hu H,Shen Z,Min D

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:α-Farnesene is a volatile sesquiterpene synthesized by the plant mevalonate (MVA) pathway through the action of α-farnesene synthase. The α-farnesene synthase 1 (MdAFS1) gene was isolated from apple peel (var. white winter pearmain), and transformed into tobacco (Nicotiana tabacum NC89). The transgenic plant...

journal_title：Biological research

authors： Liu Y,Wang L,Liu H,Zhao R,Liu B,Fu Q,Zhang Y

更新日期：2016-07-02 00:00:00

abstract：BACKGROUND:Tear desiccation on a glass surface followed by transmitted-light microscopy has served as diagnostic test for dry eye. Four distinctive morphological domains (zones I, II, III and transition band) have been recently recognized in tear microdesiccates. Physicochemical dissimilarities among those domains hamp...

journal_title：Biological research

authors： Traipe-Salas F,Traipe-Castro L,Salinas-Toro D,López D,Valenzuela F,Cartes C,Toledo-Araya H,Pérez C,López Solís R

更新日期：2016-06-03 00:00:00

abstract：BACKGROUND:Zinc finger RNA binding protein (ZFR) is involved in the regulation of growth and cancer development. However, little is known about ZFR function in pancreatic cancer. METHODS:Herein, to investigate whether ZFR is involved in tumor growth, Oncomine microarray data was firstly used to evaluate ZFR gene expre...

journal_title：Biological research

authors： Zhao X,Chen M,Tan J

更新日期：2016-05-13 00:00:00

abstract：BACKGROUND:Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity in several organisms. In this study, we have investigated the role of Co3O4-NPs in inducing phyt...

journal_title：Biological research

authors： Faisal M,Saquib Q,Alatar AA,Al-Khedhairy AA,Ahmed M,Ansari SM,Alwathnani HA,Dwivedi S,Musarrat J,Praveen S

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:Prunella vulgaris L. is a medical plant cultivated in sloping, sun-shaded areas in China. Recently, owing to air-environmental stress, especially drought stress strongly inhibits plant growth and development, the appropriate fertilizer supply can alleviate these effects. However, these is little information ...

journal_title：Biological research

authors： Chen Y,Liu L,Guo Q,Zhu Z,Zhang L

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosystem. Insect's ability to respond to temperature stress evolved through a complex adaptive process, t...

journal_title：Biological research

authors： Zhang Y,Wu H,Xie J,Jiang R,Deng C,Pang H

更新日期：2015-11-19 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented. RESULTS:In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 ...

journal_title：Biological research

authors： Xu YK,Ke Y,Wang B,Lin JH

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specif...

journal_title：Biological research

authors： Jurczak A,Kościelniak D,Papież M,Vyhouskaya P,Krzyściak W

更新日期：2015-10-31 00:00:00

abstract：BACKGROUND:Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric ox...

journal_title：Biological research

authors： Dzoyem JP,Tsamo AT,Melong R,Mkounga P,Nkengfack AE,McGaw LJ,Eloff JN

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:Impaired wound healing is a complication of diabetes and a serious problem in clinical practice. We previously found that whey protein (WP) was able to regulate wound healing normally in streptozotocin (STZ)-diabetic models. This subsequent study was designed to assess the effect of WP on heat shock protein-...

journal_title：Biological research

authors： Ahmed RR,Mahmoud A,Ahmed OM,Metwalli A,Ebaid H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary problems. It also used in treating gastric problems, body pain, and rheumatic pains of joints. The ...

journal_title：Biological research

authors： Al Mamun MA,Islam K,Alam MJ,Khatun A,Alam MM,Al-Bari MA,Alam MJ

更新日期：2015-09-12 00:00:00

abstract：BACKGROUND:CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for ...

journal_title：Biological research

authors： Takahashi H,Ikeda K,Ogawa K,Saito S,Ngoma AM,Mashimo Y,Ueda K,Furukawa M,Shichishima-Nakamura A,Ohkawara H,Nollet KE,Ohto H,Takeishi Y

更新日期：2015-07-26 00:00:00

abstract：:As regards their morphology and biology, tumours consist of heterogeneous cell populations. The cancer stem cell (CSC) hypothesis assumes that a tumour is hierarchically organized and not all of the cells are equally capable of generating descendants, similarly to normal tissue. The only cells being able to self-renew...

journal_title：Biological research

authors： Fulawka L,Donizy P,Halon A

更新日期：2014-12-10 00:00:00

abstract：BACKGROUND:The study was conducted to evaluate the in vitro thrombolytic activity, and in vivo analgesic, anti-inflammatory and antipyretic potentials of different hydrocarbon soluble extracts of Litsea glutinosa leaves for the first time widely used in the folkloric treatments in Bangladesh. This work aimed to create ...

journal_title：Biological research

authors： Bhowmick R,Sarwar MS,Dewan SM,Das A,Das B,Uddin MM,Islam MS,Islam MS

更新日期：2014-10-29 00:00:00

abstract：BACKGROUND:The root of Angelica sinensis (AS), also known as "Dang-gui," was a popular herbal medicine widely used in the treatment of gynecological diseases in China, Korea, and Japan for a long time. This study aimed to determine the effects of ethyl acetate fraction from Angelica sinensis (EAAS) on the interleukin-1...

journal_title：Biological research

authors： Lee WS,Lim JH,Sung MS,Lee EG,Oh YJ,Yoo WH

更新日期：2014-09-05 00:00:00

abstract：BACKGROUND:Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Glo...

journal_title：Biological research

authors： Berenguer AG,Fernandes AT,Oliveira S,Rodrigues M,Ornelas P,Romeira D,Serrão T,Rosa A,Câmara R

更新日期：2014-09-04 00:00:00

abstract：BACKGROUND:The Hawthorn (Crateagus sp.) mostly occurs around the temperate region of the world with a high number of species, producing a fruit with numerous beneficial effects for human health. The aim of the study was to determine organic acid and sugar contents in the fruit of a number of hawthorn species grown in E...

journal_title：Biological research

authors： Gundogdu M,Ozrenk K,Ercisli S,Kan T,Kodad O,Hegedus A

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Plants of Agave spp. perform Crassulacean acid metabolism (CAM) and are highly drought-tolerant, but little is known concerning seed germination under low water availability. The aim of this study was to assess the effect of substrate water potential (ΨW) on seed germination and contrast hydrotime parameters...

journal_title：Biological research

authors： Ramírez-Tobías HM,Peña-Valdivia CB,Trejo C,Aguirre R JR,Vaquera H H

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Although tropical climate of Thailand is suitably endowed with biodiversity of insects, flies of medical importance is not well investigated. Using information from literature search, fly survey approach and specialist's experience, we review database of Sarcophaga (Liosarcophaga) dux Thomson (Diptera: Sarco...

journal_title：Biological research

authors： Sukontason KL,Sanit S,Klong-Klaew T,Tomberlin JK,Sukontason K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:This study aimed to determine the seasonal changes of total antioxidant activity and phenolic compounds in samples taken from leaves (April, July, October) and stems (April, July, October, January) of some almond (Prunus amygdalus L.) varieties (Nonpareil, Ferragnes and Texas). RESULTS:It was indicated that...

journal_title：Biological research

authors： Sivaci A,Duman S

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Left ventricular diastolic dysfunction is one of the main characteristics of heart failure patients with a preserved left ventricular ejection fraction. As bilirubin is regarded as an important endogenous antioxidant molecule, serum total bilirubin levels were compared between heart failure patients with a p...

journal_title：Biological research

authors： Zheng H,Li Y,Xie N

更新日期：2014-03-26 00:00:00

abstract：:Hearing loss is the most common inherited sensorial deficiency in humans; about 1 in 1000 children suffer from severe or profound hearing loss at birth. Mutations in the GJB2 gene are the most common cause of prelingual, non-syndromic autosomal recessive deafness in many populations; the c.35delG mutation is the most ...

journal_title：Biological research

authors： Cifuentes L,Arancibia M,Torrente M,Acuña M,Farfán C,Ríos C

更新日期：2013-01-01 00:00:00

abstract：:Cyanobacteria display a large diversity of cellular forms ranging from unicellular to complex multicellular filaments or aggregates. Species in the group present a wide range of metabolic characteristics including the fixation of atmospheric nitrogen, resistance to extreme environments, production of hydrogen, seconda...

journal_title：Biological research

authors： Stucken K,Koch R,Dagan T

更新日期：2013-01-01 00:00:00