CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations.

Abstract:

BACKGROUND:CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS:We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS:Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.

journal_name

Biol Res

journal_title

Biological research

authors

Takahashi H,Ikeda K,Ogawa K,Saito S,Ngoma AM,Mashimo Y,Ueda K,Furukawa M,Shichishima-Nakamura A,Ohkawara H,Nollet KE,Ohto H,Takeishi Y

doi

10.1186/s40659-015-0033-8

subject

Has Abstract

pub_date

2015-07-26 00:00:00

pages

41

eissn

0716-9760

issn

0717-6287

pii

10.1186/s40659-015-0033-8

journal_volume

48

pub_type

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