Abstract:
BACKGROUND:CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS:We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS:Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.
journal_name
Biol Resjournal_title
Biological researchauthors
Takahashi H,Ikeda K,Ogawa K,Saito S,Ngoma AM,Mashimo Y,Ueda K,Furukawa M,Shichishima-Nakamura A,Ohkawara H,Nollet KE,Ohto H,Takeishi Ydoi
10.1186/s40659-015-0033-8subject
Has Abstractpub_date
2015-07-26 00:00:00pages
41eissn
0716-9760issn
0717-6287pii
10.1186/s40659-015-0033-8journal_volume
48pub_type
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