Abstract:
:The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asymmetric division) are evaluated in the light of the niche hypothesis for the stemness state. The induction of cell pluripotency and the different stem cells sources are presented (embryonic, adult and cord blood). We highlight the embryonic and adult stem cell properties and possible therapies while we emphasize the particular scientific and social values of cord blood donation to set up cord blood banks. The current scientific and legal frameworks of cord blood banks are reviewed at an international level as well as allogenic, dedicated and autologous donations. The expectations and the challenges in relation to present-day targeted diseases like diabetes mellitus type I, Parkinson's disease and myocardial infarction are evaluated in the light of the cellular therapies for regenerative medicine.
journal_name
Biol Resjournal_title
Biological researchauthors
Monti M,Perotti C,Del Fante C,Cervio M,Redi CA,Fondazione IRCCS Policlinico San Matteo, Pavia (Italia).doi
10.4067/S0716-97602012000300002subject
Has Abstractpub_date
2012-01-01 00:00:00pages
207-14issue
3eissn
0716-9760issn
0717-6287pii
S0716-97602012000300002journal_volume
45pub_type
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