Abstract:
BACKGROUND:The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS:A total of 15 differentially expressed interleukins between the colon cancer tissue and normal colon tissue were evaluated from the Cancer Genome Atlas (TCGA) database with R software and only interleukin-7 (IL-7) was significantly associated with survival. The signaling pathway associated with IL-7 was then investigated using gene enrichment analysis. In addition, subsets of TNM were analyzed in detail and univariate and multivariate COX regression analysis were conducted. Finally, we performed western blotting, immunohistochemistry, cell proliferation and cell apoptosis analysis to examine the expression of IL-7 in patients with intestinal cancer. RESULTS:The study demonstrated that IL-7 could inhibit the progression of colon cancer. In addition, IL-7 was found to be associated with overall survival (OS) and pathological stage. Further analysis of IL-7 expression with clinical data indicated that IL-7 was a key factor in inhibiting colon cancer progression. CONCLUSION:IL-7 was a key factor in inhibiting the progression of colon cancer and was closely related to overall survival.
journal_name
Biol Resjournal_title
Biological researchauthors
Wei X,Zhang Y,Yang Z,Sha Y,Pan Y,Chen Y,Cai Ldoi
10.1186/s40659-020-00287-2subject
Has Abstractpub_date
2020-05-07 00:00:00pages
20issue
1eissn
0716-9760issn
0717-6287pii
10.1186/s40659-020-00287-2journal_volume
53pub_type
杂志文章abstract::Studies of kallikrein-kinin systems since the 1930's have now led to substantial insight into the importance of this vasoactive system in the regulation of cardiovascular and renal function. It now seems clear that before long, these insights will lead to new therapeutic attacks upon diseases of the cardiovascular sys...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Invasive properties of 15 strains of thermotolerant Campylobacter (12 C. jejuni and 3 C. coli) were studied using HeLa cells cultures. In four of them (3 C. jejuni and 1 C. coli), randomly selected, intestinal perfusion experiments were conducted in order to asses enterotoxigenicity. All strains were able to invade He...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Twelve biological variables were submitted to dimensional analysis in accordance with the MLT-system of physics (M, mass; L, length; T, time). Each of these variables has a characteristic numerical value for the exponents alpha for mass, beta for length, and gamma for time. By means of Newton's reduction coefficient (...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosystem. Insect's ability to respond to temperature stress evolved through a complex adaptive process, t...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-015-0054-3
更新日期:2015-11-19 00:00:00
abstract:BACKGROUND:The root of Angelica sinensis (AS), also known as "Dang-gui," was a popular herbal medicine widely used in the treatment of gynecological diseases in China, Korea, and Japan for a long time. This study aimed to determine the effects of ethyl acetate fraction from Angelica sinensis (EAAS) on the interleukin-1...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-41
更新日期:2014-09-05 00:00:00
abstract::The major cysteine proteinase from Trypanosoma cruzi, cruzipain, can be obtained essentially homogeneous, starting from crude epimastigote extracts, in one step, by affinity chromatography on Cystatin-Sepharose (specific for cysteine proteinases) or ConA-Sepharose (specific for high mannose N-linked glycoproteins). Th...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Although several histone variants have been studied in both animal and plant organisms, little is known about their distribution during processes that involve alterations in chromatin function, such as differentiation, dedifferentiation and hormone treatment. In this study we evaluated the ratio of each histone varian...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602009000400006
更新日期:2009-01-01 00:00:00
abstract::In the last few decades, several works on event related potentials (ERPs hereafter) during sleep have been reported. In spite of numerous studies, clear methodological rules for this kind of study are often missing, making it difficult to valorize the scope of these results. We propose here a description of methodolog...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000300004
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Plants of Agave spp. perform Crassulacean acid metabolism (CAM) and are highly drought-tolerant, but little is known concerning seed germination under low water availability. The aim of this study was to assess the effect of substrate water potential (ΨW) on seed germination and contrast hydrotime parameters...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-11
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyperproliferation and excessive inflammatory response are considered to be potentially useful for pso...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00316-0
更新日期:2020-10-20 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-9
更新日期:2014-04-01 00:00:00
abstract::X-Ray diffraction is the only method currently available for the determination of the detailed three-dimensional structure of macromolecules. In this article, the principles behind the use of X-ray crystallography in the study of protein structure are presented. The results obtained in its application to several enzym...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::Treatment of tumor-bearing mice with LD12.5 values of iodoacetate; IAA (1.84 mg/100 g b.w.) and/or dimethylsulphoxide; DMSO (350 mg/100 g b.w.) significantly increased the cumulative mean survival time and percentage of survivors and reduced the mean tumor weight, compared to tumor-bearing controls, however, a more pr...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602003000200015
更新日期:2003-01-01 00:00:00
abstract::Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. T...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.1186/s40659-020-00309-z
更新日期:2020-09-16 00:00:00
abstract:BACKGROUND:Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity in several organisms. In this study, we have investigated the role of Co3O4-NPs in inducing phyt...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-016-0080-9
更新日期:2016-03-18 00:00:00
abstract::Shigella flexneri causes bacillary dysentery in humans. Essential to the establishment of the disease is the invasion of the colonic epithelial cells. Here we investigated the role of the lipopolysaccharide (LPS) O antigen in the ability of S. flexneri to adhere to and invade polarized Caco-2 cells. The S. flexneri 2a...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602012000100003
更新日期:2012-01-01 00:00:00
abstract::The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602011000300004
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been defined as an anti-cancer a...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0141-8
更新日期:2017-10-17 00:00:00
abstract::By using the fluorescent Ca2+ indicator fura 2, submicromolar levels of intracellular Ca2+ have been detected in Trypanosoma cruzi different stages. The intracellular transport mechanisms involved in maintaining Ca2+ homeostasis in T. cruzi have been characterized by measuring Ca2+ transport in digitonin-permeabilized...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asy...
journal_title:Biological research
pub_type: 历史文章,杂志文章,评审
doi:10.4067/S0716-97602012000300002
更新日期:2012-01-01 00:00:00
abstract::Red blood cell carbonic anhydrase (CA) activity has not been studied in high altitude natives. Because CA is an intraerythocytic enzyme and high altitude natives are polycythemic, it is important to know if the activity of CA per red cell volume is different from that of their sea level counterparts. Blood was collect...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602000000300006
更新日期:2000-01-01 00:00:00
abstract::Santiago de Chile has a high level of air pollution with ozone (O3), carbon monoxide (CO) and particles equal or smaller than 10 microns (PM10) usually exceeding the accepted standards. This situation should be noxious for the exposed population and particularly--in the case of O3 and PM10--for the respiratory system....
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In ...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/s0716-97602004000400028
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that long noncoding RNA (lncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this lncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC00483 on gastric can...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00283-6
更新日期:2020-04-15 00:00:00
abstract::Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different neural systems. In this study we measured the effect of stimulants on ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602004000300010
更新日期:2004-01-01 00:00:00
abstract::Object recognition memory allows discrimination between novel and familiar objects. This kind of memory consists of two components: recollection, which depends on the hippocampus, and familiarity, which depends on the perirhinal cortex (Pcx). The importance of brain-derived neurotrophic factor (BDNF) for recognition m...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000200013
更新日期:2010-01-01 00:00:00
abstract::Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca(2+)-induced Ca2+ release, whereas reducing ag...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/s0716-97602004000400007
更新日期:2004-01-01 00:00:00
abstract::Transducin serves as a mediator between the receptor protein, rhodopsin, and the effector protein, cGMP phosphodiesterase, in the visual process. Transducin is a protein composed of three polypeptides: T alpha, T beta, and T gamma, and acts as two functional units, the alpha-subunit and the beta gamma-complex. In the ...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Bilateral aspiration lesions of the fimbria-fornix were performed in 10 male Sprague Dawley rats weighing 240-300 g under chloral hydrate narcose (420 mg/kg). Another 9 animals were operated in the same way, but no aspiration was carried out to constitute a control group. A week after surgery recording and stimulation...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Despite the fact that the concept of sheet-flow in the pulmonary microcirculation of mammals was introduced more than three decades ago, the capillary circulatory model still prevails in the physiological literature. Since cardiac output is identical in the systemic and in pulmonary circulations, it is noteworthy that...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602005000100007
更新日期:2005-01-01 00:00:00