Abstract:
:Bilateral aspiration lesions of the fimbria-fornix were performed in 10 male Sprague Dawley rats weighing 240-300 g under chloral hydrate narcose (420 mg/kg). Another 9 animals were operated in the same way, but no aspiration was carried out to constitute a control group. A week after surgery recording and stimulation electrodes were lowered to the dentate gyrus and the perforant path respectively, using the same narcose. After tetanic stimulation (10 trains at 400 Hz) a potentiation of the population spike develops in both groups, but the slope of the excitatory postsynaptic potential showed no potentiation in the lesioned group. Acetylcholinesterase histochemistry confirmed a severe reduction of the cholinergic innervation to the hippocampal formation, suggesting a causal relationship to the deficits seen in long-term potentiation. This impaired potentiation could be related to the memory deficits reported for fimbria-fornix lesioned rats. Such pattern of potentiation deviates from what has been described for aged, memory deficient rats, but closely corresponds to the changes described in infantile rats.
journal_name
Biol Resjournal_title
Biological researchauthors
Bergado JA,Moreno H,Nuñez Nsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
197-202issue
2eissn
0716-9760issn
0717-6287journal_volume
29pub_type
杂志文章abstract::The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602011000300004
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pub_type: 杂志文章
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:
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journal_title:Biological research
pub_type: 杂志文章
doi:
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journal_title:Biological research
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doi:10.4067/S0716-97602013000200003
更新日期:2013-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:/S0716-97602010000200013
更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
doi:/S0716-97602008000400005
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更新日期:2015-10-31 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1186/0717-6287-47-9
更新日期:2014-04-01 00:00:00
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doi:
更新日期:1993-01-01 00:00:00
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更新日期:2020-10-20 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2017-04-12 00:00:00
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更新日期:2014-05-30 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
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journal_title:Biological research
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更新日期:2017-09-04 00:00:00
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更新日期:2016-06-03 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602011000400008
更新日期:2011-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00