Fimbria-fornix lesion impairs long-term potentiation in the dentate gyrus of the rat.

Abstract:

:Bilateral aspiration lesions of the fimbria-fornix were performed in 10 male Sprague Dawley rats weighing 240-300 g under chloral hydrate narcose (420 mg/kg). Another 9 animals were operated in the same way, but no aspiration was carried out to constitute a control group. A week after surgery recording and stimulation electrodes were lowered to the dentate gyrus and the perforant path respectively, using the same narcose. After tetanic stimulation (10 trains at 400 Hz) a potentiation of the population spike develops in both groups, but the slope of the excitatory postsynaptic potential showed no potentiation in the lesioned group. Acetylcholinesterase histochemistry confirmed a severe reduction of the cholinergic innervation to the hippocampal formation, suggesting a causal relationship to the deficits seen in long-term potentiation. This impaired potentiation could be related to the memory deficits reported for fimbria-fornix lesioned rats. Such pattern of potentiation deviates from what has been described for aged, memory deficient rats, but closely corresponds to the changes described in infantile rats.

journal_name

Biol Res

journal_title

Biological research

authors

Bergado JA,Moreno H,Nuñez N

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

197-202

issue

2

eissn

0716-9760

issn

0717-6287

journal_volume

29

pub_type

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