Abstract:
BACKGROUND:Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specific protein profiles in children diagnosed with early childhood caries (ECC) might be a basis for effective screening tests and specialized examinations which may enable progression of disease. METHODS:The objective of the studies was to determine the role of histatin-5 and β-defensing-2 as a diagnostic marker of early childhood caries progression. In this work, results of concentration determination of two salivary proteins (histatin-5 and β-defensin-2) were presented. In addition, bacterial profiles from dental plaque in various stages of ECC and control were marked. The assessment of alteration in the concentration of these two proteins in a study group of children with various stages of ECC and a control group consisting of children with no symptoms was performed by enzyme-linked immunosorbent assays. RESULTS:The statistical analysis showed a significant increase in the concentration of histatin-5 and β-defensin-2 in the study group compared to the control group and correlated with the progression of the disease. CONCLUSIONS:The confirmation of concentration changes in these proteins during the progression of dental caries may discover valuable disease progression biomarkers.
journal_name
Biol Resjournal_title
Biological researchauthors
Jurczak A,Kościelniak D,Papież M,Vyhouskaya P,Krzyściak Wdoi
10.1186/s40659-015-0050-7subject
Has Abstractpub_date
2015-10-31 00:00:00pages
61eissn
0716-9760issn
0717-6287pii
10.1186/s40659-015-0050-7journal_volume
48pub_type
杂志文章abstract:BACKGROUND:Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been defined as an anti-cancer a...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0141-8
更新日期:2017-10-17 00:00:00
abstract::Oxidant/antioxidant imbalance has been reported in some infectious diseases, including community-acquired pneumonia (CAP). The aim was to assess the antioxidant status in adults with CAP and its relationship with clinical severity at admission. Fifty-nine patients with CAP were enrolled and categorized at admission by...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602013000200013
更新日期:2013-01-01 00:00:00
abstract::The ascorbate-glutathione (ASC-GSH) cycle has an important role in defensive processes against oxidative damage generated by drought stress. In this study, the changes that take place in apoplastic and symplastic ASC-GSH cycle enzymes of the leaf and petiole were investigated under drought stress causing leaf rolling ...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602009000300006
更新日期:2009-01-01 00:00:00
abstract::Studies of kallikrein-kinin systems since the 1930's have now led to substantial insight into the importance of this vasoactive system in the regulation of cardiovascular and renal function. It now seems clear that before long, these insights will lead to new therapeutic attacks upon diseases of the cardiovascular sys...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells and develop therapeutic treatments for bone- or adipose-related diseases. In this study, the role of R...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0148-1
更新日期:2017-12-26 00:00:00
abstract::The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602011000300004
更新日期:2011-01-01 00:00:00
abstract::Unilateral brain damage which includes the hippocampus leads to memory impairments consistent with hemispheric specialization on the same side. Damage to the corpus callosum, the major connecting pathway between the left and right hemispheres, also leads to memory impairments. This suggests both hemispheric specializa...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::In mammals, neurogenesis continues during adulthood in restricted places of the nervous system, namely the subventricular zone, the dentate gyms and the olfactory epithelium. A dual role of the second messenger nitric oxide has been reported in such places, either promoting or inhibiting proliferation of neuronal prec...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/s0716-97602006000500002
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS:The mRNA and DNA copies of USP39 ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0121-z
更新日期:2017-04-12 00:00:00
abstract::A peptide from hindguts of the Triatoma infestans, the hematophagous Chagas' insect vector, activates adenylyl cyclase activity in Trypanosoma cruzi epimastigote membranes and stimulates the in vitro differentiation of epimastigotes (proliferative and non-infectious forms) to metacyclic trypomastigotes (non-proliferat...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Adenovirus genotype 7h was previously reported to be originated from a recombination event between adenovirus genotypes 7p and 3p. Based on those findings, further characterization of other adenovirus 7h strains become important to determine whether all adenovirus 7h strains arose from a single recombinational event. ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602001000200010
更新日期:2001-01-01 00:00:00
abstract::Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related chang...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602007000400007
更新日期:2007-01-01 00:00:00
abstract::Renal response to atrial natriuretic peptide in chronic cholestasis was studied in anaesthetized rats and in their isolated perfused kidneys. Cholestasis was induced by bile duct section after ligature, while controls were sham operated. Three weeks after surgery, cholestatic rats showed moderate arterial hypotension,...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Eight Chilean strains of Dunaliella salina obtained within a restricted geographic range, but exhibiting a high variability in their morphology, rate of growth and carotenogenic capacity, were analyzed by Random Amplified Polymorphic DNA (RAPD-PCR) Twenty of the 50 random primers (D, P, OPA and OPD series) that were t...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602001000100012
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive with poor prognosis. Long non-coding RNAs (lncRNAs), a group of non-coding RNAs, play important roles in the progression of PDAC. This study aimed to investigate the potential involvement of lncRNA CCAT2 in PDAC tumorigenesis. METHODS:Expression o...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0149-0
更新日期:2018-01-03 00:00:00
abstract::Most Colombian populations stem from the admixture of Caucasians, Amerindians and Negroids. In the world, these two latter ethnical groups show a significantly higher prevalence of epilepsy than the former one. We tested the hypothesis that the high prevalence of idiopathic epilepsy with generalized tonic clonic seizu...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Although several histone variants have been studied in both animal and plant organisms, little is known about their distribution during processes that involve alterations in chromatin function, such as differentiation, dedifferentiation and hormone treatment. In this study we evaluated the ratio of each histone varian...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602009000400006
更新日期:2009-01-01 00:00:00
abstract::Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different neural systems. In this study we measured the effect of stimulants on ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602004000300010
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The Hawthorn (Crateagus sp.) mostly occurs around the temperate region of the world with a high number of species, producing a fruit with numerous beneficial effects for human health. The aim of the study was to determine organic acid and sugar contents in the fruit of a number of hawthorn species grown in E...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-21
更新日期:2014-05-30 00:00:00
abstract::Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled r...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000400005
更新日期:2008-01-01 00:00:00
abstract::7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in several physiologic and pathophysiologic processes. For instance, the cyt...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000400008
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerati...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-019-0241-8
更新日期:2019-07-05 00:00:00
abstract::Transducin serves as a mediator between the receptor protein, rhodopsin, and the effector protein, cGMP phosphodiesterase, in the visual process. Transducin is a protein composed of three polypeptides: T alpha, T beta, and T gamma, and acts as two functional units, the alpha-subunit and the beta gamma-complex. In the ...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Tumor growth is the result of combined cell proliferation overwhelming cell death and neoangiogenesis. This report shows CAM angiogenesis promoted by TA3 tumor supernatant with or without low dosis of betamethasone (Minimal antiangiogenic concentration: beta-MAAC). Methylcellulose discs instilled with 10 microliters o...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602001000300010
更新日期:2001-01-01 00:00:00
abstract::Peroxisomes are thought to be formed by division of pre-existing peroxisomes after the import of newly synthesized proteins. However, it has been recently suggested that the endoplasmic reticulum (ER) provides an alternative de novo mechanism for peroxisome biogenesis in some cells. To test a possible role of the ER-G...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602007000200014
更新日期:2007-01-01 00:00:00
abstract::The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asy...
journal_title:Biological research
pub_type: 历史文章,杂志文章,评审
doi:10.4067/S0716-97602012000300002
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS:A total of 15 differential...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00287-2
更新日期:2020-05-07 00:00:00
abstract::Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In ...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/s0716-97602004000400028
更新日期:2004-01-01 00:00:00
abstract::Cells tightly regulate iron levels through the activity of iron regulatory proteins (IRPs) that bind to RNA motifs called iron responsive elements (IREs). When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferriti...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602000000200013
更新日期:2000-01-01 00:00:00
abstract::Hepcidin (Hepc) is a 25 amino acid cationic peptide with broad antibacterial and antifungal actions. A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding the transcription factor USF2 failed to produce Hepc mRNA and developed spontaneous visceral i...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000100022
更新日期:2006-01-01 00:00:00