A study on β-defensin-2 and histatin-5 as a diagnostic marker of early childhood caries progression.

Abstract:

BACKGROUND:Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) in the light of an alarming increase in resistance of bacteria and fungi against antibiotics. AMPs are used as biomarkers in diagnosis and monitoring of oral cavity pathologies. Therefore, the determination of specific protein profiles in children diagnosed with early childhood caries (ECC) might be a basis for effective screening tests and specialized examinations which may enable progression of disease. METHODS:The objective of the studies was to determine the role of histatin-5 and β-defensing-2 as a diagnostic marker of early childhood caries progression. In this work, results of concentration determination of two salivary proteins (histatin-5 and β-defensin-2) were presented. In addition, bacterial profiles from dental plaque in various stages of ECC and control were marked. The assessment of alteration in the concentration of these two proteins in a study group of children with various stages of ECC and a control group consisting of children with no symptoms was performed by enzyme-linked immunosorbent assays. RESULTS:The statistical analysis showed a significant increase in the concentration of histatin-5 and β-defensin-2 in the study group compared to the control group and correlated with the progression of the disease. CONCLUSIONS:The confirmation of concentration changes in these proteins during the progression of dental caries may discover valuable disease progression biomarkers.

journal_name

Biol Res

journal_title

Biological research

authors

Jurczak A,Kościelniak D,Papież M,Vyhouskaya P,Krzyściak W

doi

10.1186/s40659-015-0050-7

subject

Has Abstract

pub_date

2015-10-31 00:00:00

pages

61

eissn

0716-9760

issn

0717-6287

pii

10.1186/s40659-015-0050-7

journal_volume

48

pub_type

杂志文章
  • The case for a relationship between human memory, hippocampus and corpus callosum.

    abstract::Unilateral brain damage which includes the hippocampus leads to memory impairments consistent with hemispheric specialization on the same side. Damage to the corpus callosum, the major connecting pathway between the left and right hemispheres, also leads to memory impairments. This suggests both hemispheric specializa...

    journal_title:Biological research

    pub_type: 杂志文章,评审

    doi:

    authors: Zaidel DW

    更新日期:1995-01-01 00:00:00

  • Ethyl acetate fraction from Angelica sinensis inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production.

    abstract:BACKGROUND:The root of Angelica sinensis (AS), also known as "Dang-gui," was a popular herbal medicine widely used in the treatment of gynecological diseases in China, Korea, and Japan for a long time. This study aimed to determine the effects of ethyl acetate fraction from Angelica sinensis (EAAS) on the interleukin-1...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/0717-6287-47-41

    authors: Lee WS,Lim JH,Sung MS,Lee EG,Oh YJ,Yoo WH

    更新日期:2014-09-05 00:00:00

  • Progress in tear microdesiccate analysis by combining various transmitted-light microscope techniques.

    abstract:BACKGROUND:Tear desiccation on a glass surface followed by transmitted-light microscopy has served as diagnostic test for dry eye. Four distinctive morphological domains (zones I, II, III and transition band) have been recently recognized in tear microdesiccates. Physicochemical dissimilarities among those domains hamp...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/s40659-016-0089-0

    authors: Traipe-Salas F,Traipe-Castro L,Salinas-Toro D,López D,Valenzuela F,Cartes C,Toledo-Araya H,Pérez C,López Solís R

    更新日期:2016-06-03 00:00:00

  • Developmental regulation of the expression of sodium currents in Xenopus primary neurons.

    abstract::The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, due in part to the diversity of neuron subtypes. We explored the expression of voltage-gated c...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.4067/s0716-97602006000300010

    authors: Olguín P,Armisen R,Kukuljan M

    更新日期:2006-01-01 00:00:00

  • The cellular mechanisms of body iron homeostasis.

    abstract::Cells tightly regulate iron levels through the activity of iron regulatory proteins (IRPs) that bind to RNA motifs called iron responsive elements (IREs). When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferriti...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.4067/s0716-97602000000200013

    authors: Nuñez MT,Garate MA,Arredondo M,Tapia V,Muñoz P

    更新日期:2000-01-01 00:00:00

  • Dynamical complexity in cognitive neural networks.

    abstract::In the last twenty years an important effort in brain sciences, especially in cognitive science, has been the development of mathematical tool that can deal with the complexity of extensive recordings corresponding to the neuronal activity obtained from hundreds of neurons. We discuss here along with some historical i...

    journal_title:Biological research

    pub_type: 杂志文章,评审

    doi:/S0716-97602007000500009

    authors: Goles E,Palacios AG

    更新日期:2007-01-01 00:00:00

  • Plant science research productivity in Chile during the past 20 years.

    abstract::The purpose of this study was to carry out a bibliometric analysis of the articles published in Chile during 1987-2006 that were categorized into the Plant Science discipline by ISI. The data was extracted from the Web of Science datábase, obtaining a total of 911 articles for analysis. Almost half of the articles wer...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602008000200002

    authors: Krauskopf E

    更新日期:2008-01-01 00:00:00

  • Oscillatory fluid flow elicits changes in morphology, cytoskeleton and integrin-associated molecules in MLO-Y4 cells, but not in MC3T3-E1 cells.

    abstract::Interstitial fluid flow stress is one of the most important mechanical stimulations of bone cells under physiological conditions. Osteocytes and osteoblasts act as primary mechanosensors within bones, and in vitro are able to respond to fluid shear stress, both morphologically and functionally. However, there is littl...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.4067/S0716-97602012000200008

    authors: Xu H,Zhang J,Wu J,Guan Y,Weng Y,Shang P

    更新日期:2012-01-01 00:00:00

  • Sarcophaga (Liosarcophaga) dux (Diptera: Sarcophagidae): A flesh fly species of medical importance.

    abstract:BACKGROUND:Although tropical climate of Thailand is suitably endowed with biodiversity of insects, flies of medical importance is not well investigated. Using information from literature search, fly survey approach and specialist's experience, we review database of Sarcophaga (Liosarcophaga) dux Thomson (Diptera: Sarco...

    journal_title:Biological research

    pub_type: 杂志文章,评审

    doi:10.1186/0717-6287-47-14

    authors: Sukontason KL,Sanit S,Klong-Klaew T,Tomberlin JK,Sukontason K

    更新日期:2014-04-01 00:00:00

  • Fimbria-fornix lesion impairs long-term potentiation in the dentate gyrus of the rat.

    abstract::Bilateral aspiration lesions of the fimbria-fornix were performed in 10 male Sprague Dawley rats weighing 240-300 g under chloral hydrate narcose (420 mg/kg). Another 9 animals were operated in the same way, but no aspiration was carried out to constitute a control group. A week after surgery recording and stimulation...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:

    authors: Bergado JA,Moreno H,Nuñez N

    更新日期:1996-01-01 00:00:00

  • The antioxidative defense system is involved in the premature senescence in transgenic tobacco (Nicotiana tabacum NC89).

    abstract:BACKGROUND:α-Farnesene is a volatile sesquiterpene synthesized by the plant mevalonate (MVA) pathway through the action of α-farnesene synthase. The α-farnesene synthase 1 (MdAFS1) gene was isolated from apple peel (var. white winter pearmain), and transformed into tobacco (Nicotiana tabacum NC89). The transgenic plant...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/s40659-016-0088-1

    authors: Liu Y,Wang L,Liu H,Zhao R,Liu B,Fu Q,Zhang Y

    更新日期:2016-07-02 00:00:00

  • The monthly rhythm of incidence and age at menarche: thirty five years of research. The circa-vacation-study expectancy rhythm of incidence and age at menarche.

    abstract::The hypothesis that the vacation-study-expectancy scholar regime produces most of the monthly rhythm of the age at menarche (AaM) was tested. Studies on monthly menarche incidence (MI) refuted climatic factors as a main factor in this rhythm, and indicated that the main factor of this rhythm is the succession of expec...

    journal_title:Biological research

    pub_type: 杂志文章,评审

    doi:10.4067/S0716-97602013000100003

    authors: Valenzuela CY

    更新日期:2013-01-01 00:00:00

  • Biological similarity theories: a comparison with the empirical allometric equations.

    abstract::Twelve biological variables were submitted to dimensional analysis in accordance with the MLT-system of physics (M, mass; L, length; T, time). Each of these variables has a characteristic numerical value for the exponents alpha for mass, beta for length, and gamma for time. By means of Newton's reduction coefficient (...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:

    authors: Günther B,Gonzalez U,Morgado E

    更新日期:1992-01-01 00:00:00

  • Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae).

    abstract:BACKGROUND:Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric ox...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/s40659-015-0049-0

    authors: Dzoyem JP,Tsamo AT,Melong R,Mkounga P,Nkengfack AE,McGaw LJ,Eloff JN

    更新日期:2015-10-13 00:00:00

  • Ultrastructural changes of the egg apparatus associated with fertilisation of natural tetraploid Trifolium pratense L. (Fabaceae).

    abstract::The aim of this study is to describe the ultrastructural changes of the egg apparatus associated with fertilisation of the natural tetraploid Trifolium pratense. The pollen tube enters one of the synergids through the filliform apparatus from the micropyle. Before the entry of the pollen tube into the embryo sac, one ...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602009000100003

    authors: Buyukkartal HN

    更新日期:2009-01-01 00:00:00

  • Further studies on vertebrate S-type lectins: cross-reactivity between toad and human lectins.

    abstract::Galectins (S-type or S-Lac lectins) are a well-defined family of beta-galactoside animal lectins characterized by a high sequence homology in the carbohydrate-binding domain. We have previously purified and characterized the S-type lectin from the ovary of the toad Bufo arenarum. In this study, we purified the S-type ...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:

    authors: Elola MT,Fink NE

    更新日期:1997-01-01 00:00:00

  • The possible role of myosin light chain in myoblast proliferation.

    abstract::Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this r...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602009000100013

    authors: Zhang SZ,Xu Y,Xie HQ,Li XQ,Wei YQ,Yang ZM

    更新日期:2009-01-01 00:00:00

  • IcarisideII facilitates the differentiation of ADSCs to SCs via let-7i/STAT3 axis to preserve erectile function.

    abstract:BACKGROUND:IcarisideII (ICAII) could promote the differentiation of adipose tissue-derived stem cells (ADSCs) to Schwann cells (SCs), leading to improvement of erectile function (EF) and providing a realistic therapeutic option for the treatment of erectile dysfunction (ED). However, the underlying molecular mechanisms...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/s40659-019-0262-3

    authors: Ge P,Guo Y,Shen J

    更新日期:2019-10-03 00:00:00

  • Analysis of 5382insC (BRCA1) and 6174delT (BRCA2) mutations in 382 healthy Chilean women with a family history of breast cancer.

    abstract::Breast cancer is the most common malignancy among women. Chilean studies reveal that this cancer presents the third highest mortality rate. A family history of breast cancer is one of the major risk factors for the development of this disease. BRCA1 and BRCA2 are the two main hereditary breast cancer susceptibility ge...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.4067/s0716-97602002000100011

    authors: Jara L,Ampuero S,Seccia L,Bustamante M,Blanco R,Ojeda JM

    更新日期:2002-01-01 00:00:00

  • Antitumor function and mechanism of phycoerythrin from Porphyra haitanensis.

    abstract::The anti-tumor effect of R-Phycoerythrin (R-PE) from Porphyra haitanensis was studied using cell line HeLa as an in vitro model and Sarcoma-180 (S180) tumor-bearing mice as an in vivo model. The results showed that the combination treatment of R-PE and photodynamic therapy PDT) significantly inhibited the growth of He...

    journal_title:Biological research

    pub_type: 杂志文章,评审

    doi:10.4067/S0716-97602013000100013

    authors: Pan Q,Chen M,Li J,Wu Y,Zhen C,Liang B

    更新日期:2013-01-01 00:00:00

  • Seed germination of Agave species as influenced by substrate water potential.

    abstract:BACKGROUND:Plants of Agave spp. perform Crassulacean acid metabolism (CAM) and are highly drought-tolerant, but little is known concerning seed germination under low water availability. The aim of this study was to assess the effect of substrate water potential (ΨW) on seed germination and contrast hydrotime parameters...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/0717-6287-47-11

    authors: Ramírez-Tobías HM,Peña-Valdivia CB,Trejo C,Aguirre R JR,Vaquera H H

    更新日期:2014-04-01 00:00:00

  • Effects of substrate water potential in root growth of Agave salmiana Otto ex Salm-Dyck seedlings.

    abstract::The objective of this study was to test the hypothesis that root of maguey (Agave salmiana Otto ex Salm-Dyck) seedlings reacts during the first 24 h to low substrate water potential (PsiW), by anatomical modifications. Three-4 cm root length seedlings were planted in vermiculite for 24 h at PsiW between -0.03 and -2.3...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602009000200013

    authors: Peña-Valdivia CB,Sánchez-Urdaneta AB

    更新日期:2009-01-01 00:00:00

  • Genomic organization of nucleolin gene in carp fish: evidence for several genes.

    abstract::The protein nucleolin, functionally involved in the main steps of ribosome biogenesis, is codified by a single copy gene in mammals. Here we report that at least three different genes codify for this protein in carp fish (Cyprinus carpio). This is the first description of the genomic organization of nucleolin in a tel...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.4067/s0716-97602006000200017

    authors: Quezada C,Navarro C,San Martín R,Alvarez M,Molina A,Vera MI

    更新日期:2006-01-01 00:00:00

  • Anti-inflammatory and redox-protective activities of citronellal.

    abstract::The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and ...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602011000400008

    authors: Melo MS,Guimarães AG,Santana MF,Siqueira RS,De Lima Ado C,Dias AS,Santos MR,Onofre AS,Quintans JS,De Sousa DP,Almeida JR,Estevam CS,Araujo BS,Quintans-Júnior LJ

    更新日期:2011-01-01 00:00:00

  • Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.

    abstract:BACKGROUND:Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/s40659-019-0229-4

    authors: Wei H,Lin L,Zhang X,Feng Z,Wang Y,You Y,Wang X,Hou Y

    更新日期:2019-04-16 00:00:00

  • Comparison of the effect of hypothalamic neuropeptides upon luteinizing hormone secretion by cultured rat anterior pituitary cells.

    abstract::Bovine median eminence contains a factor difference from gonadotropin-releasing hormone (GnRH) than increases basal luteinizing hormone (LH) secretion and potentiates GnRH-stimulated LH release. We compared the effect of hypothalamic neuropeptides on basal and GnRH-stimulated LH secretion using rat pituitary cells und...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:

    authors: Leiva LA,Croxatto HB

    更新日期:1994-01-01 00:00:00

  • Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages.

    abstract::The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602011000300004

    authors: Gomes ML,Monteiro JC,Freitas KM,Sbervelheri MM,Dolder H

    更新日期:2011-01-01 00:00:00

  • miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/β-catenin signaling pathway.

    abstract:BACKGROUND:miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown. METHODS:In this study, an I/R-induced...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.1186/s40659-018-0179-2

    authors: Zhu X,Li W,Li H

    更新日期:2018-09-04 00:00:00

  • Immunohistochemical evidences showing the presence of thymulin containing cells located in involuted thymus and in peripheral lymphoid organs.

    abstract::Thymulin is a well-characterized thymic hormone that exists as a nonapeptide coupled to equimolar amounts of Zn2+. Thymulin is known to have multiple biological roles, including T cell differentiation, immune regulation, and analgesic functions. It has been shown that thymulin is produced by the reticulo-epithelial ce...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:/S0716-97602010000300005

    authors: Folch H,Villegas JV,Leyan V,Barría M,Eller G,Esquivel P

    更新日期:2010-01-01 00:00:00

  • Effect of psychostimulants on distinct attentional parameters in attentional deficit/hyperactivity disorder.

    abstract::Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different neural systems. In this study we measured the effect of stimulants on ...

    journal_title:Biological research

    pub_type: 杂志文章

    doi:10.4067/s0716-97602004000300010

    authors: López J,López V,Rojas D,Carrasco X,Rothhammer P,García R,Rothhammer F,Aboitiz F

    更新日期:2004-01-01 00:00:00