Abstract：
:Adenovirus genotype 7h was previously reported to be originated from a recombination event between adenovirus genotypes 7p and 3p. Based on those findings, further characterization of other adenovirus 7h strains become important to determine whether all adenovirus 7h strains arose from a single recombinational event. To explore such a possibility, 160 clinical isolates were studied after developing a PCR assay using a primer set designed to amplify the region corresponding to E3-7,7 Kd of adenovirus ADV 7p and E3-9 Kd of adenovirus 3p. The assay was able to differentiate most of the subgenus B strains from adeno 7h with the genotype 3d. The study of several adenovirus 7h clinical isolates revealed the existence of three variants of adeno 7h. One of the variants, 7h3, shows a high degree of similarity with gene E3-9 Kd of ADV 3p, but lacks the corresponding AUG codon. Our results suggest that more than one recombination event may explain the detection of three different types of adenovirus 7h. The genotype variants of adeno 7h were detected in different years, indicating that the recombination events took place independently from each other. The study of the recombination region may allow further understanding of the function of several viral polypeptides in the immune response, and understanding the mechanism involved in virulence associated to adenovirus 7h.
journal_name
Biol Resjournal_title
Biological researchauthors
Bruzzone M,Barro M,Spencer Edoi
10.4067/s0716-97602001000200010keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
75-82issue
2eissn
0716-9760issn
0717-6287journal_volume
34pub_type
杂志文章abstract：:Red blood cell carbonic anhydrase (CA) activity has not been studied in high altitude natives. Because CA is an intraerythocytic enzyme and high altitude natives are polycythemic, it is important to know if the activity of CA per red cell volume is different from that of their sea level counterparts. Blood was collect...
journal_title：Biological research
pub_type： 杂志文章
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journal_title：Biological research
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doi：
更新日期：1998-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602007000200004
更新日期：2007-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602007000400007
更新日期：2007-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2004-01-01 00:00:00
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更新日期：2012-01-01 00:00:00
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更新日期：2004-01-01 00:00:00
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doi：10.1186/s40659-017-0130-y
更新日期：2017-09-04 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602008000300004
更新日期：2008-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
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doi：10.1186/s40659-018-0207-2
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
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更新日期：2004-01-01 00:00:00
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更新日期：2006-01-01 00:00:00
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更新日期：2014-09-05 00:00:00
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更新日期：2010-01-01 00:00:00
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pub_type： 杂志文章
doi：/S0716-97602011000300004
更新日期：2011-01-01 00:00:00
