Abstract：
:Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled reaching task). Rats were trained a lateralised reaching task during an "early" (22-31 days old) or "late" (362-371 days old) postnatal period. The trained and corresponding control rats were sacrificed at day 372, immediately after the behavioural testing. The "early" trained group preserved the learned skilled reaching task when tested at day 372, without requiring any additional training. The "late" trained group showed a similar capacity to that of the "early" trained group for learning the skilled reaching task. All trained animals ("early" and "late" trained groups) showed a significant Inter hemispheric decrease of neuronal density in the corresponding motor forelimb representation area of MI (cortical layers II-III). It is concluded that learning a skilled reaching task implies long lasting structural changes in restricted cortical regions of the motor cortex. The generation and persistence of these changes probably reflect a plastic reorganization for storing and retrieving motor skills. The plastic changes were also observed in the older rats, suggesting that motor cortex maintains its plastic capacity throughout the lifespan.
journal_name
Biol Resjournal_title
Biological researchauthors
Morales Pdoi
/S0716-97602008000400005subject
Has Abstractpub_date
2008-01-01 00:00:00pages
397-404issue
4eissn
0716-9760issn
0717-6287pii
S0716-97602008000400005journal_volume
41pub_type
杂志文章abstract：BACKGROUND:Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented. RESULTS:In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 ...
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journal_title：Biological research
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更新日期：2003-01-01 00:00:00
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journal_title：Biological research
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