Abstract:
:A peptide from hindguts of the Triatoma infestans, the hematophagous Chagas' insect vector, activates adenylyl cyclase activity in Trypanosoma cruzi epimastigote membranes and stimulates the in vitro differentiation of epimastigotes (proliferative and non-infectious forms) to metacyclic trypomastigotes (non-proliferative and infectious forms). The peptide was purified from hindguts of insects fed two days before with chicken blood. After purification, the peptide showed upon SDS-PAGE a single band of about 10 kDa. The sequence for 20 residues of the amino terminus of this peptide was: H2N-Met-Leu-Thr-Ala-Glu-Asp-Lys-Lys-Leu-Ile-Gln-Gln-Ala-Trp-Glu-Lys-Ala- Ala-Ser-His. This sequence corresponds to the amino terminus of chicken alpha D-globin. A synthetic peptide with the sequence of the 40 amino acids corresponding to the amino terminus of alpha D-globin, also stimulated T. cruzi adenylyl cyclase activity and promoted metacyclogenesis.
journal_name
Biol Resjournal_title
Biological researchauthors
Fraidenraich D,Peña C,Isola EL,Lammel EM,Coso O,Añel AD,Baralle F,Torres HN,Flawia MMsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
279-83issue
1-2eissn
0716-9760issn
0717-6287journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Previous studies have shown that long noncoding RNA (lncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this lncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC00483 on gastric can...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00283-6
更新日期:2020-04-15 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000200012
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000200003
更新日期:2010-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602002000100011
更新日期:2002-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-11-24 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-9
更新日期:2014-04-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000400005
更新日期:2008-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-015-0043-6
更新日期:2015-09-12 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/s0716-97602006000500002
更新日期:2006-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000100004
更新日期:2008-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000200017
更新日期:2006-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000200013
更新日期:2010-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602011000400008
更新日期:2011-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00287-2
更新日期:2020-05-07 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000100022
更新日期:2006-01-01 00:00:00
abstract::Most Colombian populations stem from the admixture of Caucasians, Amerindians and Negroids. In the world, these two latter ethnical groups show a significantly higher prevalence of epilepsy than the former one. We tested the hypothesis that the high prevalence of idiopathic epilepsy with generalized tonic clonic seizu...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived CCL2 on microglia activation in vitro. METHODS:The rats were pretreated with CCL2 receptor inhibit...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0130-y
更新日期:2017-09-04 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000300004
更新日期:2008-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000300005
更新日期:2010-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Eight Chilean strains of Dunaliella salina obtained within a restricted geographic range, but exhibiting a high variability in their morphology, rate of growth and carotenogenic capacity, were analyzed by Random Amplified Polymorphic DNA (RAPD-PCR) Twenty of the 50 random primers (D, P, OPA and OPD series) that were t...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602001000100012
更新日期:2001-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602003000200015
更新日期:2003-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602002000300012
更新日期:2002-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602000000300006
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyperproliferation and excessive inflammatory response are considered to be potentially useful for pso...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00316-0
更新日期:2020-10-20 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:α-Farnesene is a volatile sesquiterpene synthesized by the plant mevalonate (MVA) pathway through the action of α-farnesene synthase. The α-farnesene synthase 1 (MdAFS1) gene was isolated from apple peel (var. white winter pearmain), and transformed into tobacco (Nicotiana tabacum NC89). The transgenic plant...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-016-0088-1
更新日期:2016-07-02 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000200002
更新日期:2008-01-01 00:00:00