Abstract:
:Thymulin is a well-characterized thymic hormone that exists as a nonapeptide coupled to equimolar amounts of Zn2+. Thymulin is known to have multiple biological roles, including T cell differentiation, immune regulation, and analgesic functions. It has been shown that thymulin is produced by the reticulo-epithelial cells of the thymus, and it circulates in the blood from the moment of birth, maintain its serum level until puberty diminishing thereafter in life. To study the localization of this hormone, we prepared polyclonal and monoclonal antibodies against the commercial peptide and utilized immunocytochemical techniques for visualization. The results indicate that thymulin stains the thymic reticular cells, the outer layers of Hassall's corpuscles and a large round cellular type, which is keratin-negative and does not show affinity for the common leukocyte antigen (CD-45). In mice, this thymulin-positive cell remains in the thymus throughout life and even appears in relatively increased numbers in old involuted thymi. It also appears in thymus-dependent areas of the spleen and lymph nodes, demonstrating that at least one of the thymus cells containing this peptide can be found in peripheral lymphoid tissue.
journal_name
Biol Resjournal_title
Biological researchauthors
Folch H,Villegas JV,Leyan V,Barría M,Eller G,Esquivel Pdoi
/S0716-97602010000300005subject
Has Abstractpub_date
2010-01-01 00:00:00pages
291-8issue
3eissn
0716-9760issn
0717-6287pii
S0716-97602010000300005journal_volume
43pub_type
杂志文章abstract::The development of plant transformation in the mid-1980s and of many new tools for cell biology, molecular genetics, and biochemistry has resulted in enormous progress in plant biology in the past decade. With the completion of the genome sequence of Arabidopsis thaliana just around the corner, we can expect even fast...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000200003
更新日期:2010-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1186/s40659-017-0130-y
更新日期:2017-09-04 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:/S0716-97602007000500009
更新日期:2007-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-015-0050-7
更新日期:2015-10-31 00:00:00
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journal_title:Biological research
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更新日期:2007-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
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更新日期:2020-09-16 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-016-0086-3
更新日期:2016-05-13 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/S0716-97602013000100003
更新日期:2013-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602013000200003
更新日期:2013-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000200017
更新日期:2006-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602011000400008
更新日期:2011-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-7
更新日期:2014-03-26 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-015-0049-0
更新日期:2015-10-13 00:00:00
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journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602007000100001
更新日期:2007-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602005000100007
更新日期:2005-01-01 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-018-0199-y
更新日期:2018-11-24 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-21
更新日期:2014-05-30 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-016-0089-0
更新日期:2016-06-03 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-40
更新日期:2014-09-04 00:00:00
abstract::Hearing loss is the most common inherited sensorial deficiency in humans; about 1 in 1000 children suffer from severe or profound hearing loss at birth. Mutations in the GJB2 gene are the most common cause of prelingual, non-syndromic autosomal recessive deafness in many populations; the c.35delG mutation is the most ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602013000300003
更新日期:2013-01-01 00:00:00
abstract::The neuropeptide oxytocin (OXT) is a key factor in the initiation and regulation of sociosexual behavior. The present study analyzes the effects of cohabitation and social challenge on plasma OXT concentration rates in guinea pig pairs in relation to male sociosexual behavior. The cohabitation phase lasted 3 days. On ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000200007
更新日期:2006-01-01 00:00:00
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journal_title:Biological research
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doi:10.4067/s0716-97602004000200017
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-...
journal_title:Biological research
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更新日期:2019-04-16 00:00:00
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journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602012000100003
更新日期:2012-01-01 00:00:00