Abstract:
:Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. There is accumulating evidence that epigenetic modifications may represent mechanisms underlying the links of genetic and environmental factors with increased risk of osteoporosis and bone fracture. Some RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been shown to be epigenetic regulators with significant involvement in the control of gene expression, affecting multiple biological processes, including bone metabolism. This review summarizes the results of recent studies on the mechanisms of miRNA-, lncRNA-, and circRNA-mediated osteoporosis associated with osteoblasts and osteoclasts. Deeper insights into the roles of these three classes of RNA in osteoporosis could provide unique opportunities for developing novel diagnostic and therapeutic approaches to this disease.
journal_name
Biol Resjournal_title
Biological researchauthors
Yang Y,Yujiao W,Fang W,Linhui Y,Ziqi G,Zhichen W,Zirui W,Shengwang Wdoi
10.1186/s40659-020-00309-zsubject
Has Abstractpub_date
2020-09-16 00:00:00pages
40issue
1eissn
0716-9760issn
0717-6287pii
10.1186/s40659-020-00309-zjournal_volume
53pub_type
杂志文章,评审abstract:BACKGROUND:Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosystem. Insect's ability to respond to temperature stress evolved through a complex adaptive process, t...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-015-0054-3
更新日期:2015-11-19 00:00:00
abstract::In the last twenty years an important effort in brain sciences, especially in cognitive science, has been the development of mathematical tool that can deal with the complexity of extensive recordings corresponding to the neuronal activity obtained from hundreds of neurons. We discuss here along with some historical i...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:/S0716-97602007000500009
更新日期:2007-01-01 00:00:00
abstract::The hypothesis that the vacation-study-expectancy scholar regime produces most of the monthly rhythm of the age at menarche (AaM) was tested. Studies on monthly menarche incidence (MI) refuted climatic factors as a main factor in this rhythm, and indicated that the main factor of this rhythm is the succession of expec...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/S0716-97602013000100003
更新日期:2013-01-01 00:00:00
abstract::The regeneration of natural tetraploid T. pratense, originated from Erzurum-Turkey, is reported in this study. This plant has low seed setting and hard seed problems due to polyploidy. Hypocotyl, cotyledon, apical meristems, epicotyl and young primary leaves were inoculated on MS and PC-L2 media containing different c...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000100004
更新日期:2008-01-01 00:00:00
abstract::We review the development of our knowledge and interpretations of the intermediary metabolism of Trypanosoma (Schizotrypanum) cruzi. Already in the 1950's it was clearly established that when this organism was exposed to large external concentrations of carbohydrates it was unable to catabolize them completely, even i...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranacea extract on the bioavailability of the sodium pertechnetate (Na(99m)TcO(4...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602007000200004
更新日期:2007-01-01 00:00:00
abstract::The aim of this study is to describe the ultrastructural changes of the egg apparatus associated with fertilisation of the natural tetraploid Trifolium pratense. The pollen tube enters one of the synergids through the filliform apparatus from the micropyle. Before the entry of the pollen tube into the embryo sac, one ...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602009000100003
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Glo...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-40
更新日期:2014-09-04 00:00:00
abstract::Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca(2+)-induced Ca2+ release, whereas reducing ag...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:10.4067/s0716-97602004000400007
更新日期:2004-01-01 00:00:00
abstract::X-Ray diffraction is the only method currently available for the determination of the detailed three-dimensional structure of macromolecules. In this article, the principles behind the use of X-ray crystallography in the study of protein structure are presented. The results obtained in its application to several enzym...
journal_title:Biological research
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS:The mRNA and DNA copies of USP39 ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0121-z
更新日期:2017-04-12 00:00:00
abstract::The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asy...
journal_title:Biological research
pub_type: 历史文章,杂志文章,评审
doi:10.4067/S0716-97602012000300002
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS:A total of 15 differential...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-020-00287-2
更新日期:2020-05-07 00:00:00
abstract::Invasive properties of 15 strains of thermotolerant Campylobacter (12 C. jejuni and 3 C. coli) were studied using HeLa cells cultures. In four of them (3 C. jejuni and 1 C. coli), randomly selected, intestinal perfusion experiments were conducted in order to asses enterotoxigenicity. All strains were able to invade He...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. In this work, in cortical neurons we characterized viability and changes in reduced and oxidize...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000100012
更新日期:2006-01-01 00:00:00
abstract::Hearing loss is the most common inherited sensorial deficiency in humans; about 1 in 1000 children suffer from severe or profound hearing loss at birth. Mutations in the GJB2 gene are the most common cause of prelingual, non-syndromic autosomal recessive deafness in many populations; the c.35delG mutation is the most ...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602013000300003
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to carry out a bibliometric analysis of the articles published in Chile during 1987-2006 that were categorized into the Plant Science discipline by ISI. The data was extracted from the Web of Science datábase, obtaining a total of 911 articles for analysis. Almost half of the articles wer...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602008000200002
更新日期:2008-01-01 00:00:00
abstract::Compared with morphological and life history traits, quantitative genetic variation of metabolic and related traits in animals has been poorly studied. We used flow-through VCO(2) respirometry and simultaneous activity measurement on nymphs of the sand cricket (Gryllus firmus) from inbred lines to estimate broad-sense...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602007000100001
更新日期:2007-01-01 00:00:00
abstract::The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, due in part to the diversity of neuron subtypes. We explored the expression of voltage-gated c...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602006000300010
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric ox...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-015-0049-0
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:The Hawthorn (Crateagus sp.) mostly occurs around the temperate region of the world with a high number of species, producing a fruit with numerous beneficial effects for human health. The aim of the study was to determine organic acid and sugar contents in the fruit of a number of hawthorn species grown in E...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-21
更新日期:2014-05-30 00:00:00
abstract::7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in several physiologic and pathophysiologic processes. For instance, the cyt...
journal_title:Biological research
pub_type: 杂志文章
doi:/S0716-97602010000400008
更新日期:2010-01-01 00:00:00
abstract::Allium cepa L. meristems were used as a plant model to study the p53-independent control of S and G2 phases by checkpoint pathways, in eukaryotic cells. Checkpoint blocks were induced at early and mid S by hydroxyurea. After their spontaneous override, cells became accumulated in G2-prophase, giving rise later on to a...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602003000300009
更新日期:2003-01-01 00:00:00
abstract::Prolactin (PRL) is a pituitary hormone that plays important roles in mammalian reproductive physiology, specially lactation. The regulation of PRL secretion shows important species differences. To study PRL regulation in a subhuman primate, the Cebus apella, we developed an heterologous radioimmunoassay using an antib...
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been defined as an anti-cancer a...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-017-0141-8
更新日期:2017-10-17 00:00:00
abstract::Loss of Imprinting (LOI) of IGF2 and over-expressed IGF2 are associated with tumorigenesis. Our previous epidemiological study found a relatively high frequency of IGF2 LOI in healthy mid-gestation pregnant women. The aim of this study is to determine whether the expression of IGF2 is associated with its imprinting st...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/S0716-97602012000400004
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:This study aimed to determine the seasonal changes of total antioxidant activity and phenolic compounds in samples taken from leaves (April, July, October) and stems (April, July, October, January) of some almond (Prunus amygdalus L.) varieties (Nonpareil, Ferragnes and Texas). RESULTS:It was indicated that...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/0717-6287-47-9
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Zinc finger RNA binding protein (ZFR) is involved in the regulation of growth and cancer development. However, little is known about ZFR function in pancreatic cancer. METHODS:Herein, to investigate whether ZFR is involved in tumor growth, Oncomine microarray data was firstly used to evaluate ZFR gene expre...
journal_title:Biological research
pub_type: 杂志文章
doi:10.1186/s40659-016-0086-3
更新日期:2016-05-13 00:00:00
abstract::Santiago de Chile has a high level of air pollution with ozone (O3), carbon monoxide (CO) and particles equal or smaller than 10 microns (PM10) usually exceeding the accepted standards. This situation should be noxious for the exposed population and particularly--in the case of O3 and PM10--for the respiratory system....
journal_title:Biological research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Eight Chilean strains of Dunaliella salina obtained within a restricted geographic range, but exhibiting a high variability in their morphology, rate of growth and carotenogenic capacity, were analyzed by Random Amplified Polymorphic DNA (RAPD-PCR) Twenty of the 50 random primers (D, P, OPA and OPD series) that were t...
journal_title:Biological research
pub_type: 杂志文章
doi:10.4067/s0716-97602001000100012
更新日期:2001-01-01 00:00:00