Abstract：
:The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, due in part to the diversity of neuron subtypes. We explored the expression of voltage-gated currents of Xenopus primary spinal neurons unequivocally identified by means of single-cell RT-PCR. We found that identified spinal neurons exhibit heterogeneity in the temporal appearance of voltage-gated currents. Nevertheless, all neurons progress to similar functional phenotypes. A physiological feature is the onset and increase of the expression of sodium currents. To understand the mechanisms underlying this process, we studied the effect of a dominant negative form of the transcriptional silencer REST/NRSF and found that it associates to an increase in the density of sodium currents. This observation is compatible with a role of this factor in the regulation of gene expression in neurons. These experiments constitute a proof of principle for the feasibility of analyzing molecular mechanisms of the regulation of ion channel genes during early neuronal development and provide direct evidence of the role of REST/NRSF in the control of neuronal sodium channel expression.
journal_name
Biol Resjournal_title
Biological researchauthors
Olguín P,Armisen R,Kukuljan Mdoi
10.4067/s0716-97602006000300010subject
Has Abstractpub_date
2006-01-01 00:00:00pages
483-91issue
3eissn
0716-9760issn
0717-6287pii
S0716-97602006000300010journal_volume
39pub_type
杂志文章abstract：:The development of an effective hypersensitive response (HR) in any plant system relies, not only in their gene composition and expression, but also on an effective and rapid signal transduction system. Lemon seedlings induce the phenylpropanoid pathway, which results in the de novo biosynthesis of the phytoalexin sco...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602002000300012
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abstract：:Hearing loss is the most common inherited sensorial deficiency in humans; about 1 in 1000 children suffer from severe or profound hearing loss at birth. Mutations in the GJB2 gene are the most common cause of prelingual, non-syndromic autosomal recessive deafness in many populations; the c.35delG mutation is the most ...
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journal_title：Biological research
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doi：
更新日期：1996-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/s0716-97602004000400028
更新日期：2004-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/0717-6287-47-40
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doi：
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Biological research
pub_type： 杂志文章,评审
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journal_title：Biological research
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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doi：/S0716-97602011000200009
更新日期：2011-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602009000100013
更新日期：2009-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602008000300004
更新日期：2008-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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doi：10.1186/s40659-015-0043-6
更新日期：2015-09-12 00:00:00
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journal_title：Biological research
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doi：
更新日期：1993-01-01 00:00:00
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journal_title：Biological research
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doi：
更新日期：1996-01-01 00:00:00
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doi：/S0716-97602010000200003
更新日期：2010-01-01 00:00:00
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doi：
更新日期：1997-01-01 00:00:00
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更新日期：2015-07-26 00:00:00
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更新日期：2018-11-24 00:00:00
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journal_title：Biological research
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doi：/S0716-97602009000300006
更新日期：2009-01-01 00:00:00
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更新日期：2017-12-26 00:00:00
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更新日期：2019-04-16 00:00:00
abstract：BACKGROUND:Impaired wound healing is a complication of diabetes and a serious problem in clinical practice. We previously found that whey protein (WP) was able to regulate wound healing normally in streptozotocin (STZ)-diabetic models. This subsequent study was designed to assess the effect of WP on heat shock protein-...
journal_title：Biological research
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