Abstract：
:Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In this tissue, most cytoplasmic and nuclear calcium signals originate from calcium release from internal stores, mediated either by ryanodine receptor (RyR) or IP3 receptor (IP3R) channels. The latter are located both in the sarcoplasmic reticulum (SR) and in the nuclear membrane, and their activation results in long-lasting nuclear calcium increase. The calcium signals mediated by RyR and IP3R are very different in kinetics, amplitude and subcellular localization; an open question is whether these differences are differentially sensed by transcription factors. In neurons, it is well established that calcium entry through L-type calcium channels and NMDA receptors plays a role in the regulation of gene expression. Increasing evidence, however, points to a role for calcium release from intracellular stores in this process. In this article, we discuss how RyR-mediated calcium release contributes to the activation of the calcium-dependent transcription factor CREB and the subsequent LTP generation. We present novel results from our laboratory showing ERK-mediated CREB activation by hydrogen peroxide. This activation takes place in the absence of extracellular calcium and is blocked by inhibitory ryanodine concentrations, suggesting it is caused by redox activation of RyR-mediated calcium release.
journal_name
Biol Resjournal_title
Biological researchauthors
Carrasco MA,Jaimovich E,Kemmerling U,Hidalgo Cdoi
10.4067/s0716-97602004000400028keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
701-12issue
4eissn
0716-9760issn
0717-6287journal_volume
37pub_type
杂志文章,评审abstract：:Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this r...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602009000100013
更新日期：2009-01-01 00:00:00
abstract：:Angiotensin-(1-7) [Ang-(1-7)] possesses novel biological functions that are distinct from angiotensin II (Ang II). In coronary arteries, the octapeptide Ang II and the heptapeptide Ang-(1-7) exert opposing actions. Ang II elicits vasoconstriction and Ang-(1-7) is a vasodilator. Ang-(1-7) elicits vasodilation by an end...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:Interstitial fluid flow stress is one of the most important mechanical stimulations of bone cells under physiological conditions. Osteocytes and osteoblasts act as primary mechanosensors within bones, and in vitro are able to respond to fluid shear stress, both morphologically and functionally. However, there is littl...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/S0716-97602012000200008
更新日期：2012-01-01 00:00:00
abstract：:Allium cepa L. meristems were used as a plant model to study the p53-independent control of S and G2 phases by checkpoint pathways, in eukaryotic cells. Checkpoint blocks were induced at early and mid S by hydroxyurea. After their spontaneous override, cells became accumulated in G2-prophase, giving rise later on to a...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602003000300009
更新日期：2003-01-01 00:00:00
abstract：:The anti-tumor effect of R-Phycoerythrin (R-PE) from Porphyra haitanensis was studied using cell line HeLa as an in vitro model and Sarcoma-180 (S180) tumor-bearing mice as an in vivo model. The results showed that the combination treatment of R-PE and photodynamic therapy PDT) significantly inhibited the growth of He...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/S0716-97602013000100013
更新日期：2013-01-01 00:00:00
abstract：:Oxidant/antioxidant imbalance has been reported in some infectious diseases, including community-acquired pneumonia (CAP). The aim was to assess the antioxidant status in adults with CAP and its relationship with clinical severity at admission. Fifty-nine patients with CAP were enrolled and categorized at admission by...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/S0716-97602013000200013
更新日期：2013-01-01 00:00:00
abstract：:As regards their morphology and biology, tumours consist of heterogeneous cell populations. The cancer stem cell (CSC) hypothesis assumes that a tumour is hierarchically organized and not all of the cells are equally capable of generating descendants, similarly to normal tissue. The only cells being able to self-renew...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.1186/0717-6287-47-66
更新日期：2014-12-10 00:00:00
abstract：BACKGROUND:Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented. RESULTS:In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 ...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-015-0057-0
更新日期：2015-11-17 00:00:00
abstract：BACKGROUND:Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS:The mRNA and DNA copies of USP39 ...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-017-0121-z
更新日期：2017-04-12 00:00:00
abstract：:Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. In this work, in cortical neurons we characterized viability and changes in reduced and oxidize...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602006000100012
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Glo...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/0717-6287-47-40
更新日期：2014-09-04 00:00:00
abstract：BACKGROUND:CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived CCL2 on microglia activation in vitro. METHODS:The rats were pretreated with CCL2 receptor inhibit...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-017-0130-y
更新日期：2017-09-04 00:00:00
abstract：:Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of ...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/s0716-97602002000200004
更新日期：2002-01-01 00:00:00
abstract：:Control of smooth muscle is vital for health. The major route to contraction is a rise in intracellular [Ca2+], determined by the entry and efflux of Ca2+ and release and re-uptake into the sarcoplasmic reticulum (SR). We review these processes in myometrium, to better understand excitation-contraction coupling and de...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602004000400017
更新日期：2004-01-01 00:00:00
abstract：:In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In this context, anti...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602011000200009
更新日期：2011-01-01 00:00:00
abstract：:Guanine nucleotide binding proteins (GTP-binding proteins) function as transducers of signals in different cellular processes. We have identified several GTP-binding proteins in Trypanosoma cruzi by Western blot analyses. Six polypeptide bands, p20, p25, p28, p31, p37 and p38, were specifically detected in epimastigot...
journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Breast cancer is the most common malignancy among women. Chilean studies reveal that this cancer presents the third highest mortality rate. A family history of breast cancer is one of the major risk factors for the development of this disease. BRCA1 and BRCA2 are the two main hereditary breast cancer susceptibility ge...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602002000100011
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-019-0229-4
更新日期：2019-04-16 00:00:00
abstract：:The objective of this study was to test the hypothesis that root of maguey (Agave salmiana Otto ex Salm-Dyck) seedlings reacts during the first 24 h to low substrate water potential (PsiW), by anatomical modifications. Three-4 cm root length seedlings were planted in vermiculite for 24 h at PsiW between -0.03 and -2.3...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602009000200013
更新日期：2009-01-01 00:00:00
abstract：:Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses a...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/s0716-97602006000100002
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Although tropical climate of Thailand is suitably endowed with biodiversity of insects, flies of medical importance is not well investigated. Using information from literature search, fly survey approach and specialist's experience, we review database of Sarcophaga (Liosarcophaga) dux Thomson (Diptera: Sarco...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.1186/0717-6287-47-14
更新日期：2014-04-01 00:00:00
abstract：:Invasive properties of 15 strains of thermotolerant Campylobacter (12 C. jejuni and 3 C. coli) were studied using HeLa cells cultures. In four of them (3 C. jejuni and 1 C. coli), randomly selected, intestinal perfusion experiments were conducted in order to asses enterotoxigenicity. All strains were able to invade He...
journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:IcarisideII (ICAII) could promote the differentiation of adipose tissue-derived stem cells (ADSCs) to Schwann cells (SCs), leading to improvement of erectile function (EF) and providing a realistic therapeutic option for the treatment of erectile dysfunction (ED). However, the underlying molecular mechanisms...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-019-0262-3
更新日期：2019-10-03 00:00:00
abstract：BACKGROUND:The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS:A total of 15 differential...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-020-00287-2
更新日期：2020-05-07 00:00:00
abstract：:Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid secon...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/s0716-97602002000200014
更新日期：2002-01-01 00:00:00
abstract：:Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. T...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.1186/s40659-020-00309-z
更新日期：2020-09-16 00:00:00
abstract：:Twelve biological variables were submitted to dimensional analysis in accordance with the MLT-system of physics (M, mass; L, length; T, time). Each of these variables has a characteristic numerical value for the exponents alpha for mass, beta for length, and gamma for time. By means of Newton's reduction coefficient (...
journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Bovine median eminence contains a factor difference from gonadotropin-releasing hormone (GnRH) than increases basal luteinizing hormone (LH) secretion and potentiates GnRH-stimulated LH release. We compared the effect of hypothalamic neuropeptides on basal and GnRH-stimulated LH secretion using rat pituitary cells und...
journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerati...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-019-0241-8
更新日期：2019-07-05 00:00:00
abstract：BACKGROUND:Papillary thyroid cancer (PTC) is the most common malignancy of all thyroid cancers. LncRNA LINC00460 has been proved to play roles in the oncogenesis and progression of various tumors, including papillary thyroid cancer. However, the potential molecular mechanism of LINC00460 in PTC is poorly investigated. ...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-019-0269-9
更新日期：2019-12-23 00:00:00
