Abstract：
:In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In this context, antioxidant defence plays a critical role in male fertility. Vitamin C, a micronutrient required for a wide variety of metabolic functions, has long been associated with male reproduction. Two systems for vitamin C transport have been described in mammals. Facilitative hexose transporters (GLUTs), with 14 known isoforms to date, GLUT1-GLUT14, transport the oxidized form of vitamin C (dehydroascorbic acid) into the cells. Sodium ascorbic acid co-transporters (SVCTs), SVCT1 and SVCT2 transport the reduced form of vitamin C (ascorbic acid). Sertoli cells control germ cell proliferation and differentiation through cell-cell communication and form the blood-testis barrier. Because the blood-testis barrier limits direct access of molecules from the plasma into the adluminal compartment of the seminiferous tubule, one important question is the method by which germ cells obtain vitamin C. Some interesting results have thrown light on this matter. Expression of SVCT2 and some isoforms of GLUT transporters in the testis have previously been described. Our group has demonstrated that Sertoli cells express functionally active vitamin C transporters. Kinetic characteristics were described for both transport systems (SVCT and GLUT systems). Sertoli cells are able to transport both forms of vitamin C. These findings are extremely relevant, because Sertoli cells may control the amount of vitamin C in the adluminal compartment, as well as regulating the availability of this metabolite throughout spermatogenesis.
journal_name
Biol Resjournal_title
Biological researchauthors
Angulo C,Maldonado R,Pulgar E,Mancilla H,Córdova A,Villarroel F,Castro MA,Concha IIdoi
/S0716-97602011000200009subject
Has Abstractpub_date
2011-01-01 00:00:00pages
169-80issue
2eissn
0716-9760issn
0717-6287pii
S0716-97602011000200009journal_volume
44pub_type
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journal_title：Biological research
pub_type： 杂志文章
doi：
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pub_type： 历史文章,杂志文章
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journal_title：Biological research
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journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/0717-6287-47-7
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journal_title：Biological research
pub_type： 杂志文章
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journal_title：Biological research
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journal_title：Biological research
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journal_title：Biological research
pub_type： 杂志文章
doi：
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journal_title：Biological research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2017-10-17 00:00:00
