p53-independent checkpoint controls in a plant cell model.

abstract：BACKGROUND:IcarisideII (ICAII) could promote the differentiation of adipose tissue-derived stem cells (ADSCs) to Schwann cells (SCs), leading to improvement of erectile function (EF) and providing a realistic therapeutic option for the treatment of erectile dysfunction (ED). However, the underlying molecular mechanisms...

journal_title：Biological research

authors： Ge P,Guo Y,Shen J

更新日期：2019-10-03 00:00:00

abstract：:In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In this context, anti...

journal_title：Biological research

authors： Angulo C,Maldonado R,Pulgar E,Mancilla H,Córdova A,Villarroel F,Castro MA,Concha II

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric ox...

journal_title：Biological research

authors： Dzoyem JP,Tsamo AT,Melong R,Mkounga P,Nkengfack AE,McGaw LJ,Eloff JN

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity in several organisms. In this study, we have investigated the role of Co3O4-NPs in inducing phyt...

journal_title：Biological research

authors： Faisal M,Saquib Q,Alatar AA,Al-Khedhairy AA,Ahmed M,Ansari SM,Alwathnani HA,Dwivedi S,Musarrat J,Praveen S

更新日期：2016-03-18 00:00:00

abstract：:Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses a...

journal_title：Biological research

authors： Moreira PI,Zhu X,Liu Q,Honda K,Siedlak SL,Harris PL,Smith MA,Perry G

更新日期：2006-01-01 00:00:00

abstract：:The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranacea extract on the bioavailability of the sodium pertechnetate (Na(99m)TcO(4...

journal_title：Biological research

authors： Moreno SR,Arnobio A,De Carvalho JJ,Nascimento L,Oliveira Timoteo M,Olej B,Rocha EK,Pereira M,Bernardo-Filho M,Caldas LQ

更新日期：2007-01-01 00:00:00

abstract：:The development of an effective hypersensitive response (HR) in any plant system relies, not only in their gene composition and expression, but also on an effective and rapid signal transduction system. Lemon seedlings induce the phenylpropanoid pathway, which results in the de novo biosynthesis of the phytoalexin sco...

journal_title：Biological research

authors： Ortega X,Polanco R,Castañeda P,Perez LM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS:The mRNA and DNA copies of USP39 ...

journal_title：Biological research

authors： Gan Z,Han K,Lin S,Hu H,Shen Z,Min D

更新日期：2017-04-12 00:00:00

abstract：:Hyptidendron canum (Pohl ex Benth.) Harley is a native tree of the Brazilian Savannah. The fish Oreochromis niloticus L. was used as an experimental model to determine the bioactivity of the crude ethanol extract as well as ethyl acetate, hexanic and chloroform fractions obtained from its leaves. The plant ethanol ext...

journal_title：Biological research

authors： Fiuza TS,Silva PC,Paula JR,Tresvenzol LM,Sabóia-Morais SM

更新日期：2009-01-01 00:00:00

abstract：:The anti-tumor effect of R-Phycoerythrin (R-PE) from Porphyra haitanensis was studied using cell line HeLa as an in vitro model and Sarcoma-180 (S180) tumor-bearing mice as an in vivo model. The results showed that the combination treatment of R-PE and photodynamic therapy PDT) significantly inhibited the growth of He...

journal_title：Biological research

authors： Pan Q,Chen M,Li J,Wu Y,Zhen C,Liang B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Understanding the molecular basis underlying the formation of bone-forming osteocytes and lipid-storing adipocytes will help provide insights into the cause of disorders originating in stem/progenitor cells and develop therapeutic treatments for bone- or adipose-related diseases. In this study, the role of R...

journal_title：Biological research

authors： Madrigal A,Tan L,Zhao Y

更新日期：2017-12-26 00:00:00

abstract：:Cyanobacteria display a large diversity of cellular forms ranging from unicellular to complex multicellular filaments or aggregates. Species in the group present a wide range of metabolic characteristics including the fixation of atmospheric nitrogen, resistance to extreme environments, production of hydrogen, seconda...

journal_title：Biological research

authors： Stucken K,Koch R,Dagan T

更新日期：2013-01-01 00:00:00

abstract：:Cells tightly regulate iron levels through the activity of iron regulatory proteins (IRPs) that bind to RNA motifs called iron responsive elements (IREs). When cells become iron-depleted, IRPs bind to IREs present in the mRNAs of ferritin and the transferrin receptor, resulting in diminished translation of the ferriti...

journal_title：Biological research

authors： Nuñez MT,Garate MA,Arredondo M,Tapia V,Muñoz P

更新日期：2000-01-01 00:00:00

abstract：:Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled r...

journal_title：Biological research

authors： Morales P

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to investigate the in vitro cytotoxic activity of total extract of MeOH (70%) and partition fractions of hexan, chloroform (CHCL3), ethylacetate (EtOAc) and MeOH-H2O of brown algae species (Sargassum swartzii, Cystoseira myrica, Colpomenia sinuosa) found in the Persian Gulf against in differe...

journal_title：Biological research

authors： Khanavi M,Nabavi M,Sadati N,Shams Ardekani M,Sohrabipour J,Nabavi SM,Ghaeli P,Ostad SN

更新日期：2010-01-01 00:00:00

abstract：:Unilateral brain damage which includes the hippocampus leads to memory impairments consistent with hemispheric specialization on the same side. Damage to the corpus callosum, the major connecting pathway between the left and right hemispheres, also leads to memory impairments. This suggests both hemispheric specializa...

journal_title：Biological research

authors： Zaidel DW

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Prunella vulgaris L. is a medical plant cultivated in sloping, sun-shaded areas in China. Recently, owing to air-environmental stress, especially drought stress strongly inhibits plant growth and development, the appropriate fertilizer supply can alleviate these effects. However, these is little information ...

journal_title：Biological research

authors： Chen Y,Liu L,Guo Q,Zhu Z,Zhang L

更新日期：2016-02-24 00:00:00

abstract：:Breast cancer is the most common malignancy among women. Chilean studies reveal that this cancer presents the third highest mortality rate. A family history of breast cancer is one of the major risk factors for the development of this disease. BRCA1 and BRCA2 are the two main hereditary breast cancer susceptibility ge...

journal_title：Biological research

authors： Jara L,Ampuero S,Seccia L,Bustamante M,Blanco R,Ojeda JM

更新日期：2002-01-01 00:00:00

abstract：:The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and ...

journal_title：Biological research

authors： Melo MS,Guimarães AG,Santana MF,Siqueira RS,De Lima Ado C,Dias AS,Santos MR,Onofre AS,Quintans JS,De Sousa DP,Almeida JR,Estevam CS,Araujo BS,Quintans-Júnior LJ

更新日期：2011-01-01 00:00:00

abstract：:Thymulin is a well-characterized thymic hormone that exists as a nonapeptide coupled to equimolar amounts of Zn2+. Thymulin is known to have multiple biological roles, including T cell differentiation, immune regulation, and analgesic functions. It has been shown that thymulin is produced by the reticulo-epithelial ce...

journal_title：Biological research

authors： Folch H,Villegas JV,Leyan V,Barría M,Eller G,Esquivel P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hyperproliferation and excessive inflammatory response are considered to be potentially useful for pso...

journal_title：Biological research

authors： Gao J,Chen F,Fang H,Mi J,Qi Q,Yang M

更新日期：2020-10-20 00:00:00

abstract：:Hepcidin (Hepc) is a 25 amino acid cationic peptide with broad antibacterial and antifungal actions. A likely role for Hepc in iron metabolism was suggested by the observation that mice having disruption of the gene encoding the transcription factor USF2 failed to produce Hepc mRNA and developed spontaneous visceral i...

journal_title：Biological research

authors： Mena NP,Esparza AL,Núñez MT

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The characterization of the dynamic process of veins walls is essential to understand venous functioning under normal and pathological conditions. However, little work has been done on dynamic venous properties. AIM:To characterize vein compliance (C), viscosity (eta), peak-strain (W St) and dissipated (W(D...

journal_title：Biological research

authors： Zócalo Y,Bia D,Lluberas S,Armentano RL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been defined as an anti-cancer a...

journal_title：Biological research

authors： Du M,Zhang Z,Gao T

更新日期：2017-10-17 00:00:00

abstract：:In mammals, neurogenesis continues during adulthood in restricted places of the nervous system, namely the subventricular zone, the dentate gyms and the olfactory epithelium. A dual role of the second messenger nitric oxide has been reported in such places, either promoting or inhibiting proliferation of neuronal prec...

journal_title：Biological research

authors： Sulz L,Bacigalupo J

更新日期：2006-01-01 00:00:00

abstract：:Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this r...

journal_title：Biological research

authors： Zhang SZ,Xu Y,Xie HQ,Li XQ,Wei YQ,Yang ZM

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of Mediterranean-type diet (MD), high-fat diet (HFD), and red wine supplementation on plasma concentration of emergent haemostatic cardiovascular risk factors (HCVRF) and on variables of primary haemostasis (bleeding time, plasma von Willebrand factor and platelet aggre...

journal_title：Biological research

authors： Mezzano D

更新日期：2004-01-01 00:00:00

abstract：:Renal response to atrial natriuretic peptide in chronic cholestasis was studied in anaesthetized rats and in their isolated perfused kidneys. Cholestasis was induced by bile duct section after ligature, while controls were sham operated. Three weeks after surgery, cholestatic rats showed moderate arterial hypotension,...

journal_title：Biological research

authors： Valdivieso A,Boric MP,Riquelme A,Roblero J

更新日期：1993-01-01 00:00:00

abstract：:Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals involved in regulation of gene expression in skeletal muscle has been addressed only recently. In ...

journal_title：Biological research

authors： Carrasco MA,Jaimovich E,Kemmerling U,Hidalgo C

更新日期：2004-01-01 00:00:00

abstract：:The regeneration of natural tetraploid T. pratense, originated from Erzurum-Turkey, is reported in this study. This plant has low seed setting and hard seed problems due to polyploidy. Hypocotyl, cotyledon, apical meristems, epicotyl and young primary leaves were inoculated on MS and PC-L2 media containing different c...

journal_title：Biological research

authors： Cölgeçen H,Toker MC

更新日期：2008-01-01 00:00:00