Regional differences in veins wall viscosity, compliance, energetics and damping: analysis of the pressure-diameter relationship during cyclical overloads.

Abstract:

BACKGROUND:The characterization of the dynamic process of veins walls is essential to understand venous functioning under normal and pathological conditions. However, little work has been done on dynamic venous properties. AIM:To characterize vein compliance (C), viscosity (eta), peak-strain (W St) and dissipated (W(D)) energy, damping (zeta), and their regional differences in order to evaluate their role in venous functioning during volume-pressure overloads. METHODS:In a mock circulation, pressure (P) and diameter (D) of different veins (anterior cava, jugular and femoral; from 7 sheep), were registered during cyclical volume-pressure pulses. From the P-D relationship, C, W(St) and zeta (at low and high P-D levels), eta and W(D) were calculated. RESULTS:For each vein there were P-dependent differences in biomechanical, energetics, and damping capability. There were regional-differences in C, eta), W(St) and W(D) (p<0.05), but not in zeta. CONCLUSION:The regional-dependent differences in dynamics and energetics, and regional-similitude in damping could be important to ensure venous functioning during acute overloads. The lower C and higher W(St) and W(D) found in back-limb veins (femoral), commonly submitted to high volume-pressure loads (i.e. during walking), could be considered relevant to ensure adequate venous system functionality and venous wall protection simultaneously.

journal_name

Biol Res

journal_title

Biological research

authors

Zócalo Y,Bia D,Lluberas S,Armentano RL

doi

/S0716-97602008000200012

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

227-33

issue

2

eissn

0716-9760

issn

0717-6287

pii

S0716-97602008000200012

journal_volume

41

pub_type

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