Abstract：
:Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. In this work, in cortical neurons we characterized viability and changes in reduced and oxidized glutathione levels in response to a protocol of iron accumulation. We found that massive death occurred after 2 days in culture with 10 microM Fe. Surviving cells developed an adaptative response that included increased synthesis of GSH and the maintenance of a glutathione-based reduction potential. These results highlight the fundamental role of glutathione homeostasis in the antioxidant response and provide novel insights into the adaptative mechanisms of neurons subjected to progressive iron loads.
journal_name
Biol Resjournal_title
Biological researchauthors
Aguirre P,Mena N,Tapia V,Rojas A,Arredondo M,Núñez MTdoi
10.4067/s0716-97602006000100012subject
Has Abstractpub_date
2006-01-01 00:00:00pages
103-4issue
1eissn
0716-9760issn
0717-6287pii
S0716-97602006000100012journal_volume
39pub_type
杂志文章abstract：BACKGROUND:Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented. RESULTS:In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 ...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-015-0057-0
更新日期：2015-11-17 00:00:00
abstract：:Control of smooth muscle is vital for health. The major route to contraction is a rise in intracellular [Ca2+], determined by the entry and efflux of Ca2+ and release and re-uptake into the sarcoplasmic reticulum (SR). We review these processes in myometrium, to better understand excitation-contraction coupling and de...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602004000400017
更新日期：2004-01-01 00:00:00
abstract：:Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different neural systems. In this study we measured the effect of stimulants on ...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602004000300010
更新日期：2004-01-01 00:00:00
abstract：:Despite the fact that the concept of sheet-flow in the pulmonary microcirculation of mammals was introduced more than three decades ago, the capillary circulatory model still prevails in the physiological literature. Since cardiac output is identical in the systemic and in pulmonary circulations, it is noteworthy that...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602005000100007
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric ox...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-015-0049-0
更新日期：2015-10-13 00:00:00
abstract：:Cyanobacteria display a large diversity of cellular forms ranging from unicellular to complex multicellular filaments or aggregates. Species in the group present a wide range of metabolic characteristics including the fixation of atmospheric nitrogen, resistance to extreme environments, production of hydrogen, seconda...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/S0716-97602013000400009
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The characterization of the dynamic process of veins walls is essential to understand venous functioning under normal and pathological conditions. However, little work has been done on dynamic venous properties. AIM:To characterize vein compliance (C), viscosity (eta), peak-strain (W St) and dissipated (W(D...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602008000200012
更新日期：2008-01-01 00:00:00
abstract：:We review the development of our knowledge and interpretations of the intermediary metabolism of Trypanosoma (Schizotrypanum) cruzi. Already in the 1950's it was clearly established that when this organism was exposed to large external concentrations of carbohydrates it was unable to catabolize them completely, even i...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in several physiologic and pathophysiologic processes. For instance, the cyt...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602010000400008
更新日期：2010-01-01 00:00:00
abstract：:X-Ray diffraction is the only method currently available for the determination of the detailed three-dimensional structure of macromolecules. In this article, the principles behind the use of X-ray crystallography in the study of protein structure are presented. The results obtained in its application to several enzym...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Object recognition memory allows discrimination between novel and familiar objects. This kind of memory consists of two components: recollection, which depends on the hippocampus, and familiarity, which depends on the perirhinal cortex (Pcx). The importance of brain-derived neurotrophic factor (BDNF) for recognition m...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602010000200013
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechanism on human osteosarcoma has not been fully explored yet. METHODS:The mRNA and DNA copies of USP39 ...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-017-0121-z
更新日期：2017-04-12 00:00:00
abstract：BACKGROUND:The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS:A total of 15 differential...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-020-00287-2
更新日期：2020-05-07 00:00:00
abstract：:Many motor skills, once acquired, are stored over a long time period, probably sustained by permanent neuronal changes. Thus, in this paper we have investigated with quantitative stereology the generation and persistence of neuronal density changes in primary motor cortex (MI) following motor skill learning (skilled r...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602008000400005
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The root of Angelica sinensis (AS), also known as "Dang-gui," was a popular herbal medicine widely used in the treatment of gynecological diseases in China, Korea, and Japan for a long time. This study aimed to determine the effects of ethyl acetate fraction from Angelica sinensis (EAAS) on the interleukin-1...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/0717-6287-47-41
更新日期：2014-09-05 00:00:00
abstract：:After the progress made during the genomics era, bioinformatics was tasked with supporting the flow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and computational chemistry tools to store, standardize, analyze, and visualize nanobiotechnological inform...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/S0716-97602011000100006
更新日期：2011-01-01 00:00:00
abstract：:Compared with morphological and life history traits, quantitative genetic variation of metabolic and related traits in animals has been poorly studied. We used flow-through VCO(2) respirometry and simultaneous activity measurement on nymphs of the sand cricket (Gryllus firmus) from inbred lines to estimate broad-sense...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602007000100001
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerati...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-019-0241-8
更新日期：2019-07-05 00:00:00
abstract：:In mammals, neurogenesis continues during adulthood in restricted places of the nervous system, namely the subventricular zone, the dentate gyms and the olfactory epithelium. A dual role of the second messenger nitric oxide has been reported in such places, either promoting or inhibiting proliferation of neuronal prec...
journal_title：Biological research
pub_type： 杂志文章,评审
doi：10.4067/s0716-97602006000500002
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Changed temperature not only threaten agricultural production, but they also affect individual biological behavior, population and community of many insects, and consequently reduce the stability of our ecosystem. Insect's ability to respond to temperature stress evolved through a complex adaptive process, t...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-015-0054-3
更新日期：2015-11-19 00:00:00
abstract：BACKGROUND:Accumulating studies have demonstrated that high-mobility group A2 (HMGA2), an oncofetal protein, plays a role in tumor development and progression. However, the molecular role of HMGA2 in ovarian carcinoma is yet to be established. MicroRNAs (miRNAs), a group of small noncoding RNAs, negatively regulate gen...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-018-0199-y
更新日期：2018-11-24 00:00:00
abstract：BACKGROUND:Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity in several organisms. In this study, we have investigated the role of Co3O4-NPs in inducing phyt...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-016-0080-9
更新日期：2016-03-18 00:00:00
abstract：:Shigella flexneri causes bacillary dysentery in humans. Essential to the establishment of the disease is the invasion of the colonic epithelial cells. Here we investigated the role of the lipopolysaccharide (LPS) O antigen in the ability of S. flexneri to adhere to and invade polarized Caco-2 cells. The S. flexneri 2a...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/S0716-97602012000100003
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown. METHODS:In this study, an I/R-induced...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-018-0179-2
更新日期：2018-09-04 00:00:00
abstract：:Galectins (S-type or S-Lac lectins) are a well-defined family of beta-galactoside animal lectins characterized by a high sequence homology in the carbohydrate-binding domain. We have previously purified and characterized the S-type lectin from the ovary of the toad Bufo arenarum. In this study, we purified the S-type ...
journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602011000300004
更新日期：2011-01-01 00:00:00
abstract：:Loss of Imprinting (LOI) of IGF2 and over-expressed IGF2 are associated with tumorigenesis. Our previous epidemiological study found a relatively high frequency of IGF2 LOI in healthy mid-gestation pregnant women. The aim of this study is to determine whether the expression of IGF2 is associated with its imprinting st...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/S0716-97602012000400004
更新日期：2012-01-01 00:00:00
abstract：:The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, due in part to the diversity of neuron subtypes. We explored the expression of voltage-gated c...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602006000300010
更新日期：2006-01-01 00:00:00
abstract：:The aim of this study was to investigate the in vitro cytotoxic activity of total extract of MeOH (70%) and partition fractions of hexan, chloroform (CHCL3), ethylacetate (EtOAc) and MeOH-H2O of brown algae species (Sargassum swartzii, Cystoseira myrica, Colpomenia sinuosa) found in the Persian Gulf against in differe...
journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602010000100005
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that long noncoding RNA (lncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this lncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC00483 on gastric can...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-020-00283-6
更新日期：2020-04-15 00:00:00
