Abstract：
:Control of smooth muscle is vital for health. The major route to contraction is a rise in intracellular [Ca2+], determined by the entry and efflux of Ca2+ and release and re-uptake into the sarcoplasmic reticulum (SR). We review these processes in myometrium, to better understand excitation-contraction coupling and develop strategies for preventing problematic labours. The main mechanism of elevating [Ca2+] is voltage-gated L-type channels, due to pacemaker activity, which can be modulated by agonists. The rise of [Ca2+] produces Ca-calmodulin and activates MLCK. This phosphorylates myosin and force results. Without Ca2+ entry uterine contraction fails. The Na/Ca exchanger (NCX) and plasma membrane Ca-ATPase (PMCA) remove Ca2+, with contributions of 30% and 70% respectively. Studies with PMCA-4 knockout mice show that it contributes to reducing [Ca2+] and relaxation. The SR contributes to relaxation by vectorially releasing Ca2+ to the efflux pathways, and thereby increasing their rates. Agonists binding produces IP3 which can release Ca from the SR but inhibition of SR Ca2+ release increases contractions and Ca2+ transients. It is suggested that SR Ca2+ targets K+ channels on the surface membrane and thereby feedback to inhibit excitability and contraction.
journal_name
Biol Resjournal_title
Biological researchauthors
Matthew A,Shmygol A,Wray Sdoi
10.4067/s0716-97602004000400017keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
617-24issue
4eissn
0716-9760issn
0717-6287journal_volume
37pub_type
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doi：10.4067/s0716-97602004000100011
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journal_title：Biological research
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journal_title：Biological research
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doi：
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pub_type： 历史文章,杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Biological research
pub_type： 杂志文章,评审
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doi：10.1186/s40659-020-00316-0
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pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
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doi：/S0716-97602009000300006
更新日期：2009-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/0717-6287-47-56
更新日期：2014-10-29 00:00:00
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pub_type： 杂志文章
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pub_type： 历史文章,杂志文章
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pub_type： 杂志文章,评审
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doi：10.1186/0717-6287-47-9
更新日期：2014-04-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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doi：/S0716-97602011000400008
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