Abstract：
:Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid second messenger that regulates cell growth and apoptosis and is produced during signal transduction by hydrolysis of membrane phospholipids. Protein kinase Cs are a family of diacyglycerol responsive enzymes that are recruited to cellular membranes as a consequence of diacylglycerol production where they phosphorylate specific target proteins responsible for regulating cell growth. In this review, we will first summarize our current understanding of the role of specific proteins kinase C isoforms in the induction of cell growth/apoptosis. Subsequently, we will discuss how insights gained in lipid-mediated regulation of protein kinase Cs promotes our understanding of the role specific family members play in regulating cell growth. Finally, other diacylglycerol binding proteins involved in regulating apoptosis will be discussed.
journal_name
Biol Resjournal_title
Biological researchauthors
Wright MM,McMaster CRdoi
10.4067/s0716-97602002000200014keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
223-9issue
2eissn
0716-9760issn
0717-6287journal_volume
35pub_type
杂志文章,评审abstract：:The hypothesis that the vacation-study-expectancy scholar regime produces most of the monthly rhythm of the age at menarche (AaM) was tested. Studies on monthly menarche incidence (MI) refuted climatic factors as a main factor in this rhythm, and indicated that the main factor of this rhythm is the succession of expec...
journal_title：Biological research
pub_type： 杂志文章,评审
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602008000100004
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602011000300004
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pub_type： 杂志文章
doi：/S0716-97602010000100005
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doi：
更新日期：1999-01-01 00:00:00
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doi：
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journal_title：Biological research
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更新日期：1998-01-01 00:00:00
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journal_title：Biological research
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doi：
更新日期：1996-01-01 00:00:00
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doi：
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doi：
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doi：/S0716-97602011000200009
更新日期：2011-01-01 00:00:00
