Compensatory responses induced by oxidative stress in Alzheimer disease.

Abstract:

:Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.

journal_name

Biol Res

journal_title

Biological research

authors

Moreira PI,Zhu X,Liu Q,Honda K,Siedlak SL,Harris PL,Smith MA,Perry G

doi

10.4067/s0716-97602006000100002

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

7-13

issue

1

eissn

0716-9760

issn

0717-6287

pii

S0716-97602006000100002

journal_volume

39

pub_type

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