解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The photodegradation of the S(+)- and R(-)-ketoprofen (KP) enantiomers in the bovine serum albumin matrix was studied by steady-state photolysis with the use of lambda(irr) > 320 nm and transient absorption spectroscopy with lambda(exc) = 355 nm, at 1/1 and 2/1 KP/BSA molar ratios. R(-)-KP was found to be more labile ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-07-11-RA-608
更新日期:2006-01-01 00:00:00
abstract::The thermodynamic parameters for the formation of the free radicals upon electron transfer quenching of the flavin triplet state (3FMN) by tryptophan and tyrosine, Delta(FR)H and Delta(FR)V, were obtained in aqueous solution by the application of laser-induced optoacoustic spectroscopy at various temperatures. The Del...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-03-22-RA-468
更新日期:2006-01-01 00:00:00
abstract::Photodynamic therapy (PDT) is frequently accompanied by induction of systemic immunosuppression. Photochemical mechanisms underlying this effect are not completely understood. Here, we demonstrate the immunosuppressive activity of photooxidation products of protoporphyrin IX dimethyl ester (PPIX) in a murine model of ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-04-26-RA-500
更新日期:2005-11-01 00:00:00
abstract::Immunosuppressive doses of solar-simulated UV radiation activate lymph node B cells that can suppress primary immunity by inhibiting the function of dendritic cells. The aim of this study was to determine the waveband responsible for activation of these suppressor B cells. We exposed C57BL/6 mice to various doses of e...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-04-20-RA-495
更新日期:2005-11-01 00:00:00
abstract::In the present study, photodynamic activity of a novel photosensitizer (PS), Chlorin e(6)-2.5 N-methyl-d-glucamine (BLC 1010), was evaluated using the chorioallantoic membrane (CAM) as an in vivo model. After intravenous (i.v.) injection of BLC 1010 into the CAM vasculature, the applicability of this drug for photodyn...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-02-23-RA-448
更新日期:2005-11-01 00:00:00
abstract::Singlet oxygen ((1)O(2)) is the most important cytotoxic agent in photodynamic therapy (PDT). The feasibility of using a chemiluminescence (CL) probe, 3,7-dihydro-6-[4-(2-(N'-(5-fluoresceinyl)thioureido)ethoxy)phenyl]-2-methylimidazo{1,2-a}pyrazin-3-one sodium salt (fluoresceinyl Cypridina luciferin analog, FCLA), to ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-05-20-RA-536
更新日期:2005-11-01 00:00:00
abstract::Vitamin D production in human skin occurs only when incident UV radiation exceeds a certain threshold. From simulations of UV irradiances worldwide and throughout the year, we have studied the dependency of the extent and duration of cutaneous vitamin D production in terms of latitude, time, total ozone, clouds, aeros...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-11-19-RN-375
更新日期:2005-11-01 00:00:00
abstract::This paper reviews briefly the evidence for an association between various measures of UV radiation (UVR) exposure and the development of cancer. Issues such as data quality, study design, measurement variation, comparability of studies, and quantification of UV exposure in relation to skin cancer are discussed. A ran...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
doi:10.1562/2005-02-18-IR-445
更新日期:2005-11-01 00:00:00
abstract::We previously reported that Shewanella oneidensis MR-1 is extremely sensitive to natural solar radiation (NSR). Here we analyzed the global transcriptional profile of MR-1 during a 1-h recovering period after exposure to ambient solar light at a dose that yields about 20% survival rate on a Luria-Bertani (LB) plate. W...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-04-15-RA-490
更新日期:2005-11-01 00:00:00
abstract::Pterins are heterocyclic compounds with important biological functions, and most of them may exist in two acid-base forms in the pH range between 3 and 13 in aqueous solution. In this work, the photophysical properties of acid and basic forms of six compounds of the pterin family (6-hydroxymethylpterin [HPT], 6-methyl...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-05-10-RA-522
更新日期:2005-09-01 00:00:00
abstract::Novel water-soluble polymeric photosensitizers (SPO) based on starch and containing porphyrin chromophores were synthesized and studied. The polymers were soluble in water and in dimethyl sulfoxide. Photophysical studies and solubilization of molecular probes proved the formation of hydrophobic, rigid microdomains in ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-03-07-RA-455
更新日期:2005-09-01 00:00:00
abstract::We examined the influence of solar ultraviolet-B radiation (UV-B; 280-320 nm) on the growth, biomass production and phenylpropanoid concentrations of Deschampsia antarctica during the springtime ozone depletion season at Palmer Station, along the Antarctic Peninsula. Treatments involved placing filters on frames over ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-09-18-RA-321
更新日期:2005-09-01 00:00:00
abstract::Plant responses to light spectral quality can be exploited to deliver a range of agronomically desirable end points in protected crops. This can be achieved using plastics with specific spectral properties as crop covers. We have studied the responses of a range of crops to plastics that have either (a) increased tran...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-12-06-RA-392
更新日期:2005-09-01 00:00:00
abstract::The interaction with amino acids of the excited states of the N-oxide resazurin and its deoxygenation product resorufin, has been studied in aqueous solution at pH 7.5. Steady-state and time-resolved studies show that the fluorescence is quenched by amino acids. Complexation of the dyes in the ground state with aromat...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-10-12-RA-342
更新日期:2005-07-01 00:00:00
abstract::Topical photodynamic therapy is used for a variety of malignant and pre-malignant skin disorders, including Bowen's Disease and Superficial Basal Cell Carcinoma. A haem precursor, typically 5-aminolevulinic acid (ALA), acting as a prodrug, is absorbed and converted by the haem biosynthetic pathway to photoactive proto...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
doi:10.1562/2004-08-23-IR-283
更新日期:2005-07-01 00:00:00
abstract::Carp (Cyprinus carpio) were repeatedly exposed to 0, 60, 120 and 240 mJ/cm2 ultraviolet B (UVB) radiation three times in 1 week (short-term exposure) or 12 times in 4 weeks (long-term exposure). The effect of UVB on the functioning of the carp immune system was studied on day 2 after the final irradiation. After short...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-07-13-RA-231
更新日期:2005-05-01 00:00:00
abstract::Synovial sarcoma (SS) is one of common malignant soft-tissue tumors and is encountered most commonly in children and young adults. It frequently involves or invades major neurovascular structures and bones, and its local recurrence rate after simple resection has been reported to be as high as up to 80%. Because major...
journal_title:Photochemistry and photobiology
pub_type: 临床试验,杂志文章
doi:10.1562/2004-06-27-RA-218
更新日期:2005-05-01 00:00:00
abstract::Two-photon laser scanning microscopy (TPLSM) of endogenous reduced nicotinamide adenine dinucleotide (NAD(P)H) provides important information regarding the cellular metabolic state. When imaging the punctate mitochondrial fluorescence originating from NAD(P)H in a rat basophilic leukemia (RBL) cell at low laser powers...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-08-05-RA-263
更新日期:2005-03-01 00:00:00
abstract::Molecular beacons (MB) are becoming more common as sequence-selective detectors of nucleic acids. Although they can easily detect single-base mismatches, they have never been used to directly detect DNA or RNA damage. To measure the degree of ultraviolet (UV) light damage in oligonucleotides, we report a novel MB appr...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-09-02-RA-301
更新日期:2005-03-01 00:00:00
abstract::A novel continuous-flow photocatalytic reactor was designed to decompose toluene by using porous nickel sheets that were coated with a Fe-doped TiO2 catalyst. While locating the UV lamp at the central axis, the catalyst sheets were located along the inner wall and positioned vertically with an equal space of 50 mm alo...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-06-19-RA-207
更新日期:2005-03-01 00:00:00
abstract::Excessive exposure of solar ultraviolet (UV) radiation, particularly its UV-B component, to humans causes many adverse effects that include erythema, hyperplasia, hyperpigmentation, immunosuppression, photoaging and skin cancer. In recent years, there is increasing use of botanical agents in skin care products. Pomegr...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-08-06-RA-264
更新日期:2005-01-01 00:00:00
abstract::The Escherichia coli protein YcgF contains a photosensory flavin adenine dinucleotide (FAD)-binding BLUF domain covalently linked to an EAL domain, which is predicted to have cyclic-di-guanosine monophosphate (GMP) phosphodiesterase activity. We have cloned, overexpressed and purified this protein, which we refer to a...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-06-16-RA-203
更新日期:2004-11-01 00:00:00
abstract::Low-power lasers are commonly used in human medicine for treatment of various pathological conditions, but mechanisms of their healing effects are still poorly understood. The results of this study provide information related to these effects at the cellular level. Two different protozoan species, Euglena gracilis and...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2004)080<0531:EOLLIO>2.0.CO;2
更新日期:2004-11-01 00:00:00
abstract::The effect of netropsin on the oxidative reactions of duplex DNA was examined. One-electron oxidation of DNA creates a radical cation that migrates through duplex DNA and reacts primarily at GG steps. Netropsin is a dication that specifically binds primarily by hydrogen bonding in the minor groove at sites that have f...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2004)080<0456:EONOOO>2.0.CO;2
更新日期:2004-11-01 00:00:00
abstract::The ciliate Stentor coeruleus exhibits photodispersal, that is, these cells swim away from light sources and collect in dimly lighted areas. We imaged and reconstructed the tracks of 48 Stentor to determine which swimming behaviors produced their photodispersal. We observed that their photodispersal is not due to a ch...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2004)080<0401:BPPISC>2.0.CO;2
更新日期:2004-11-01 00:00:00
abstract::Intermolecular interactions of human serum proteins with a hydrophilic nonmetalloporphyrin, 13,17-bis(1-carboxypropionyl)carbomoylethyl-8-ethenyl-2-hydroxy-3-hydroxyiminoethylidene-2,7,12,18-tetramethylporphyrin sodium salt (ATX-S10 (Na)), or a hydrophilic gallium-metalloporphyrin, diethylenetriamine pentaacetic acid ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-03-17-RA-117
更新日期:2004-09-01 00:00:00
abstract::We study the fluorescence lifetime of the well-known 1-pyrene butyric acid (PBA) to assess oxygen concentrations in living cells. The behavior of the probe is first studied in water, ethanol, protein solution and liposome suspension. The Stern-Volmer plot of these solutions is linear, and the bimolecular reaction rate...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-03-11-RA-109
更新日期:2004-09-01 00:00:00
abstract::On direct photoexcitation, subpicosecond time-resolved absorption spectroscopy revealed that the 1B(u)-type singlet excited state of all-trans-lycopene in chloroform was about seven times more efficient than all-trans-beta-carotene in generating the radical cation. The time constant of radical cation generation from t...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-04-22-RA-147
更新日期:2004-09-01 00:00:00
abstract::Stratospheric ozone depletion has caused an increase in the amount of ultraviolet-B (UV-B) radiation reaching the earth's surface. Numerous investigations have demonstrated that the effect of UV-B enhancements on plants includes reduction in grain yield, alteration in species competition, susceptibility to disease and...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-05-03-RA-156.1
更新日期:2004-07-01 00:00:00
abstract::Effects of solvent, pH and hydrogen bonding with N-methylimidazole (MIm) on the photophysical properties of 1-hydroxyfluorenone (1HOF) have been studied. Fluorescence lifetime, fluorescence quantum yield and triplet yield measurements demonstrated that intersystem crossing was the dominant process in apolar media and ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2004-01-27RA-067.1
更新日期:2004-07-01 00:00:00
abstract::Antifungal activity is positively correlated to furanocoumarin content in extracts of the traditional phytomedicine northern prickly ash (Zanthoxylum americanum Mill. [Rutaceae]). The specificity of these furanocoumarins in inhibiting replication of DNA was investigated with reference to significant base composition d...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2003-12-10-ra.1
更新日期:2004-06-01 00:00:00
abstract::Current conditions of 2-11 kJ m(-2) day(-1) of UV-B radiation and temperatures of >30 degrees C during flowering in cotton cultivated regions are projected to increase in the future. A controlled environment study was conducted in sunlit growth chambers to determine the effects of UV-B radiation and temperature on phy...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2003-11-19-ra.1
更新日期:2004-05-01 00:00:00
abstract::We studied the spectral characteristics of the larvae of three sympatric Belgian species of fireflies, Lampyris noctiluca, Phosphaenus hemipterus and Lamprohiza splendidula. An in vivo spectral study was performed to compare bioluminescence spectra. The emission spectrum of a laboratory reared female L. noctiluca was ...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2003-11-11-RA.1
更新日期:2004-04-01 00:00:00
abstract::Recent developments in optical technologies have the potential to improve the speed and accuracy of screening and diagnosis of curable precancerous lesions and early cancer, thereby decreasing the costs of detection and management of epithelial malignancies. The development of molecular-specific contrast agents for ma...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/fr-03-15.1
更新日期:2004-03-01 00:00:00
abstract::Comparative study of 13,15-[N-(2-hydroxyethyl)]cycloimide chlorin p6 (2), 13,15-(N-acetoxy)cycloimide chlorin p6 (3), 13,15-(N-hydroxy)cycloimide chlorin p6 methyl ester (4) and 13,15-(N-methoxy)cycloimide chlorin p6 methyl ester (5) together with the previously investigated 13,15-[N-(3-hydroxypropyl)]cycloimide chlor...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2004)079<0172:csoppo>2.0.co;2
更新日期:2004-02-01 00:00:00
abstract::Synthesis of extracellular matrix (ECM) proteins and their degradation by matrix metalloproteinases (MMP) are part of the dermal remodeling resulting from chronic exposure of skin to ultraviolet radiation (UVR). We have compared two alternative mechanisms for these responses, namely, a direct mechanism in which UV-B o...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Polarized steady-state fluorescence and fluorescence excitation spectra as well as time-resolved fluorescence for B-phycoerythrin (B-PE) from red algae, Porphyridium cruentum, embedded in polyvinyl stretched films were measured. The lifetimes of polarized fluorescence were analyzed using exponential components and fra...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Aspects of different calibration procedures for erythemally weighing broadband radiometers are presented in this study. These instruments are common in projects dealing with ultraviolet radiation effects on humans. Many erythemally weighing broadband radiometers are still operated using a single calibration factor (cf...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2003)078<0603:SCFBSU>2.0.CO;2
更新日期:2003-12-01 00:00:00
abstract::Although ultraviolet-B (UV-B) radiation is potentially harmful, it is an important component of terrestrial radiation to which plants have been exposed since invading land. Since then, plants have evolved mechanisms to avoid and repair UV radiation damage; therefore, it is not surprising that photomorphogenic response...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
doi:10.1562/0031-8655(2003)078<0529:hduprc>2.0.co;2
更新日期:2003-12-01 00:00:00
abstract::Photodetection (PD) and photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PPIX) accumulation are approaches to detect and treat dysplasia and early cancer in the gastrointestinal tract and in the urinary bladder. Because ALA-induced PPIX production is limited, we synthesized ALA es...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2003)078<0481:naaepp>2.0.co;2
更新日期:2003-11-01 00:00:00