Abstract:
:The effect of netropsin on the oxidative reactions of duplex DNA was examined. One-electron oxidation of DNA creates a radical cation that migrates through duplex DNA and reacts primarily at GG steps. Netropsin is a dication that specifically binds primarily by hydrogen bonding in the minor groove at sites that have four or more contiguous A.T base pairs. We showed that the oxidation potential of netropsin is less than that of any of the four nucleobases. We find that netropsin quenches the oxidative reactions of DNA independent of whether it is specifically bound. Within the Perrin model of static quenching, a netropsin within a rather large fixed volume around the DNA is an effective quencher.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Roberts LW,Schuster GBdoi
10.1562/0031-8655(2004)080<0456:EONOOO>2.0.CO;2subject
Has Abstractpub_date
2004-11-01 00:00:00pages
456-61issue
3eissn
0031-8655issn
1751-1097pii
2004-07-26-RA-246Rjournal_volume
80pub_type
杂志文章abstract::Efficacy of ionizing radiation (I/R) was compared with phototoxic effects of photodynamic therapy (PDT) in vitro using two cell lines derived from patients with head and neck squamous cell carcinoma (HNSCC). A cell line derived from a donor with a human papilloma virus (HPV) infection was more responsive to I/R but si...
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
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doi:
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journal_title:Photochemistry and photobiology
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pub_type: 杂志文章
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