Abstract:
:Efficacy of ionizing radiation (I/R) was compared with phototoxic effects of photodynamic therapy (PDT) in vitro using two cell lines derived from patients with head and neck squamous cell carcinoma (HNSCC). A cell line derived from a donor with a human papilloma virus (HPV) infection was more responsive to I/R but significantly less responsive to PDT than a cell line derived from an HPV-free patient. Cell death after I/R in the HPV(+) cell line was associated with increased DEVDase activity, a hallmark of apoptosis. The HPV(-) line was considerably less responsive to I/R, with DEVDase activity greatly reduced, suggesting an impaired apoptotic program. In contrast, the HPV(-) cells were readily killed by PDT when the ER was among the targets for photodamage. While DEVDase activity was enhanced, the death pathway appears to involve paraptosis until the degree of photodamage reached the LD99 range. These data suggest that PDT-induced paraptosis can be a death pathway for cells with an impaired apoptotic program.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Kessel D,Cho WJ,Rakowski J,Kim HE,Kim HCdoi
10.1111/php.13150subject
Has Abstractpub_date
2020-05-01 00:00:00pages
652-657issue
3eissn
0031-8655issn
1751-1097journal_volume
96pub_type
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