Effects of HPV Status on Responsiveness to Ionizing Radiation vs Photodynamic Therapy in Head and Neck Cancer Cell lines.

Abstract:

:Efficacy of ionizing radiation (I/R) was compared with phototoxic effects of photodynamic therapy (PDT) in vitro using two cell lines derived from patients with head and neck squamous cell carcinoma (HNSCC). A cell line derived from a donor with a human papilloma virus (HPV) infection was more responsive to I/R but significantly less responsive to PDT than a cell line derived from an HPV-free patient. Cell death after I/R in the HPV(+) cell line was associated with increased DEVDase activity, a hallmark of apoptosis. The HPV(-) line was considerably less responsive to I/R, with DEVDase activity greatly reduced, suggesting an impaired apoptotic program. In contrast, the HPV(-) cells were readily killed by PDT when the ER was among the targets for photodamage. While DEVDase activity was enhanced, the death pathway appears to involve paraptosis until the degree of photodamage reached the LD99 range. These data suggest that PDT-induced paraptosis can be a death pathway for cells with an impaired apoptotic program.

journal_name

Photochem Photobiol

authors

Kessel D,Cho WJ,Rakowski J,Kim HE,Kim HC

doi

10.1111/php.13150

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

652-657

issue

3

eissn

0031-8655

issn

1751-1097

journal_volume

96

pub_type

杂志文章
  • Protective properties of novel S-acyl-glutathione thioesters against ultraviolet-induced oxidative stress.

    abstract::UV-induced toxicity is characterized by marked oxidative stress, accompanied by the depletion of key cellular antioxidants, particularly glutathione (GSH). Replenishing cellular GSH may represent a means of counteracting UV-induced toxicity: however, treatment with free GSH is not therapeutically effective due to its ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01231.x

    authors: Wright D,Zampagni M,Evangelisti E,Conti S,D'Adamio G,Goti A,Becatti M,Fiorillo C,Taddei N,Cecchi C,Liguri G

    更新日期:2013-03-01 00:00:00

  • Mechanisms for luminol-augmented chemiluminescence from neutrophils induced by leukotriene B4 and N-formyl-methionyl-leucyl-phenylalanine.

    abstract::Neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine (fMLP) or leukotriene B4 (LTB4) generated kinetically distinctive luminol augmented chemiluminescence (LCL). Inhibitors of .O2- [superoxide-dismutase (SOD) or tiron], H2O2 (catalase), myeloperoxidase, MPO, (NaN3), HOCl (taurine) and .OH (mannitol) hampe...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb04099.x

    authors: Gyllenhammar H

    更新日期:1989-02-01 00:00:00

  • Attitudes, Beliefs, and Measures Taken by Parents to Protect Their Children from the Sun in Guangzhou City, China.

    abstract::Excessive sun exposure can cause sunburn, suntan, skin photoaging, and even skin cancer. Skin photoaging conflicts with the human pursuit of a young and beautiful appearance. Some research data indicate that the incidence of skin cancer in the Chinese has been increasing, although it remains lower than in whites. To e...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12623

    authors: Wan M,Hu R,Li Y,Wang Y,Xie X,Yue P,Guan L,Lai W

    更新日期:2016-09-01 00:00:00

  • The family of GFP-like proteins: structure, function, photophysics and biosensor applications. Introduction and perspective.

    abstract::In this issue, we offer a symposium-in-print that is focused on several new advancements in fundamental research related to the family of GFP (green fluorescent protein)-like proteins. A few applied aspects are also included to illustrate the impact this amazing set of colored proteins has made on our understanding of...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1562/2005-10-02-IR-708

    authors: Wachter RM

    更新日期:2006-03-01 00:00:00

  • Pluronic F-127: An Efficient Delivery Vehicle for 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH or Photochlor).

    abstract::To determine the impact of delivery vehicles in photosensitizing efficacy of HPPH, a hydrophobic photosensitizer was dissolved in various formulations: 1% Tween 80/5% dextrose, Pluronic P-123 and Pluronic F-127 in 0.5%, 1% and 2% phosphate buffer solutions (PBS). HPPH was also conjugated to Pluronic F-127, and the res...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13183

    authors: Cacaccio J,Durrani F,Cheruku RR,Borah B,Ethirajan M,Tabaczynski W,Pera P,Missert JR,Pandey RK

    更新日期:2020-05-01 00:00:00

  • Quenching of singlet molecular oxygen (1O2) by azide anion in solvent mixtures.

    abstract::The azide ion is a strong physical quencher of singlet molecular oxygen (1O2) and is frequently employed to show involvement of 1O2 in oxidation processes. Rate constants (k(q)) for the quenching of 1O2 by azide are routinely used as standards to calculate k(q) values for quenching by other substrates. We have measure...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)074<0760:qosmoo>2.0.co;2

    authors: Li MY,Cline CS,Koker EB,Carmichael HH,Chignell CF,Bilski P

    更新日期:2001-12-01 00:00:00

  • Optical Spectroscopy as a Method for Skin Cancer Risk Assessment.

    abstract::Skin cancer is the most prevalent cancer, and its assessment remains a challenge for physicians. This study reports the application of an optical sensing method, elastic scattering spectroscopy (ESS), coupled with a classifier that was developed with machine learning, to assist in the discrimination of skin lesions th...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13140

    authors: Rodriguez-Diaz E,Manolakos D,Christman H,Bonning MA,Geisse JK,A'Amar OM,Leffell DJ,Bigio IJ

    更新日期:2019-11-01 00:00:00

  • Determination by fluorimetric titration of the ionization constants of ciprofloxacin in solution and in the presence of liposomes.

    abstract::A fluorescence titration method was applied for the determination of pKa of ciprofloxacin (CPX) in solution. Values of 6.18 +/- 0.05 and 8.76 +/- 0.03 were obtained for pKa1 and pKa2, respectively. The method was used to determine the ionization constants in the presence of liposomes of dipalmitoylphosphatidylcholine ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0014:dbftot>2.0.co;2

    authors: Vázquez JL,Berlanga M,Merino S,Domènech O,Viñas M,Montero MT,Hernández-Borrell J

    更新日期:2001-01-01 00:00:00

  • Light emission accompanies oxygen uptake during the peroxidative metabolism of tetracyclines.

    abstract::Tetracycline molecules offer several sites for peroxidative metabolism of the type known to lead to oxygen consumption and electronic excitation. Accordingly, when tetracycline and chlortetracycline were exposed to horseradish peroxidase in the presence of hydrogen peroxide, oxygen was taken up and light emission was ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1993.tb09588.x

    authors: Gilio VE,Cilento G

    更新日期:1993-09-01 00:00:00

  • Isolation and characteristics of the PSI-LHCI-LHCII supercomplex under high light.

    abstract::We developed a novel method for the isolation of the PSI-LHCI-LHCII complex from spinach leaves. The supercomplex was resolved into a core complex (CPI), LHCII trimers, LHCI dimers and LHCII monomers using green gel electrophoresis. We then investigate changes in the fluorescence and absorption spectra of PSI-LHCI-LHC...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2010.00830.x

    authors: Qin X,Wang W,Wang K,Xin Y,Kuang T

    更新日期:2011-01-01 00:00:00

  • Influence of Heterogeneity on the Ultrafast Photoisomerization Dynamics of Pfr in Cph1 Phytochrome.

    abstract::Photoisomerization of a protein-bound chromophore is the basis of light sensing and signaling in many photoreceptors. Phytochrome photoreceptors can be photoconverted reversibly between the Pr and Pfr states through photoisomerization of the methine bridge between rings C and D. Ground-state heterogeneity of the chrom...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12743

    authors: Stensitzki T,Yang Y,Wölke AL,Knapp EW,Hughes J,Mroginski MA,Heyne K

    更新日期:2017-05-01 00:00:00

  • Use of potassium iodide as a chemical actinometer.

    abstract::Aqueous solutions of KI were examined for use as chemical actinometers to measure 254 nm (germicidal) radiation. Irradiation results in electron ejection from iodide such that aqueous electrons and iodine atoms are formed. In the presence of N2O, an electron scavenger, recombination of these two reactive species is el...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1993.tb04986.x

    authors: Rahn RO

    更新日期:1993-12-01 00:00:00

  • Photobiomodulation Affects Key Cellular Pathways of all Life-Forms: Considerations on Old and New Laser Light Targets and the Calcium Issue.

    abstract::After 50 years of studies on photobiomodulation (PBM), there is still so much to investigate to understand the laser light-nonplant cells interactions. The current scientific knowledge allows to say that the phenomena induced by PBM are based on cellular pathways that are the key points of cell life. The mitochondria ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13032

    authors: Amaroli A,Ferrando S,Benedicenti S

    更新日期:2019-01-01 00:00:00

  • Asiatic Acid Glucosamine Salt Alleviates Ultraviolet B-induced Photoaging of Human Dermal Fibroblasts and Nude Mouse Skin.

    abstract::Herbal extracts including asiatic acid (AA) have become popular candidates of anti-photoaging agents due to their anti-inflammatory and antioxidant properties and minimal side effect. Nevertheless, low bioavailability due to poor solubility limits their practical application. In this study, a highly bioavailable form ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13160

    authors: Huang J,Tu T,Wang W,Zhou G,Zhang W,Wu X,Liu W

    更新日期:2020-01-01 00:00:00

  • Protective effects of cyclooxygenase-2 inhibitors on narrow-band ultraviolet B-irradiated epidermal Ia+ Langerhans cells and Thy-1+ dendritic epidermal T cells in mice.

    abstract::Cyclooxygenase (COX)-2 inhibitors are known to be used as chemopreventative agents against certain malignancies. Thus far, there has been very limited information on whether COX-2 inhibitors protect against chronic narrow-band UVB (NB-UVB)-induced immunosuppression. The present study investigated the effect of nonsele...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2007.00289.x

    authors: Wu Y,Tai CL,Wei H,He F,Wang Y,Zhao Y,Chen HD

    更新日期:2008-03-01 00:00:00

  • Hypothesis--ultraviolet-B irradiance and vitamin D reduce the risk of viral infections and thus their sequelae, including autoimmune diseases and some cancers.

    abstract::Many viral infections reach clinical significance in winter, when it is cold, relative humidity is lowest and vitamin D production from solar ultraviolet-B irradiation is at its nadir. Several autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus and asthma, are linked to viral infections. Vitamin ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.2007.00266.x

    authors: Grant WB

    更新日期:2008-03-01 00:00:00

  • Type I and Type II Photosensitized Oxidation Reactions: Guidelines and Mechanistic Pathways.

    abstract::Here, 10 guidelines are presented for a standardized definition of type I and type II photosensitized oxidation reactions. Because of varied notions of reactions mediated by photosensitizers, a checklist of recommendations is provided for their definitions. Type I and type II photoreactions are oxygen-dependent and in...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/php.12716

    authors: Baptista MS,Cadet J,Di Mascio P,Ghogare AA,Greer A,Hamblin MR,Lorente C,Nunez SC,Ribeiro MS,Thomas AH,Vignoni M,Yoshimura TM

    更新日期:2017-07-01 00:00:00

  • Solar UVB dosimetry by amplification of short and long segments in phage lambda DNA.

    abstract::DNA UVB dosimeters, consisting of minidots of dried bacteriophage DNA placed on a UV-transparent polymer film, were analyzed by polymerase chain reactions (PCR). Ultraviolet-B dosimetry obtained with amplification of phage lambda DNA of segments of 1.08 kilobase pairs (kbp) and 2.24 kbp was compared with that obtained...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb03205.x

    authors: Yoshida H,Regan JD

    更新日期:1997-11-01 00:00:00

  • Biodistribution and pharmacokinetic studies of a porphyrin dimer photosensitizer (Oxdime) by fluorescence imaging and spectroscopy in mice bearing xenograft tumors.

    abstract::Herein, we present a study of the pharmacokinetics and biodistribution of a butadiyne-linked conjugated porphyrin dimer (Oxdime) designed to have high near-infrared (NIR) 2-photon absorption cross-section for photodynamic therapy (PDT). Changes in biodistribution over time were monitored in mice carrying B16-F10 melan...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01194.x

    authors: Khurana M,Ulrich S,Kim A,Moriyama Y,Netchev G,Akens MK,Anderson HL,Wilson BC

    更新日期:2012-11-01 00:00:00

  • Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast.

    abstract::Time-resolved reflectance and transmittance spectroscopy was applied to measure in vivo the absorption and transport scattering spectra of the female breast from 610 to 1010 nm. Three measurement configurations were used to probe different breast regions, and data were collected two or three times in each of the five ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Cubeddu R,D'Andrea C,Pifferi A,Taroni P,Torricelli A,Valentini G

    更新日期:2000-09-01 00:00:00

  • Immobilized organic photosensitizers with versatile reactivity for various visible-light applications.

    abstract::Various photosensitizers were grafted by conventional peptide coupling methods to functionalized silica with several macroscopic shapes (powders, films) or embedded in highly transparent and microporous silica xerogel monoliths. Owing to the transparency and free-standing shape of the monoliths, the transient species ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12166

    authors: Ronzani F,Saint-Cricq P,Arzoumanian E,Pigot T,Blanc S,Oelgemöller M,Oliveros E,Richard C,Lacombe S

    更新日期:2014-03-01 00:00:00

  • Role of xanthurenic acid 8-O-beta-D-glucoside, a novel fluorophore that accumulates in the brunescent human eye lens.

    abstract::We have been able to identify a blue fluorophore from the low-molecular weight soluble fraction of human adult nondiabetic brunescent cataract lenses as xanthurenic acid 8-O-beta-D-glucoside (XA8OG) (excitation = 338 nm and emission = 440 nm). To determine the role of this fluorophore in the lens, we have examined its...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2002)076<0368:roxaod>2.0.co;2

    authors: Thiagarajan G,Shirao E,Ando K,Inoue A,Balasubramanian D

    更新日期:2002-09-01 00:00:00

  • Empirical evaluation of a simple analytical formula for the ultraviolet index.

    abstract::This paper focuses on the estimation of the UV Index (UVI) for all sky conditions using a simple analytical parameterization involving three independent variables: the solar zenith angle, the total ozone column and the clearness index. Measurements of the UVI made at Badajoz and Cáceres (Southwestern Spain) from Janua...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2010.00860.x

    authors: Antón M,Serrano A,Cancillo ML,García JA,Madronich S

    更新日期:2011-03-01 00:00:00

  • Photostability of Terbinafine Under UVA Irradiation: The Effect of UV Absorbers.

    abstract::The photostability of drugs administered topically on unprotected skin is a complex phenomenon that could be connected with the loss of activity or, rather rarely, the occurrence of toxic degradation products. In this study, an in-depth investigation of the photostability of terbinafine, in both solutions and formulat...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13075

    authors: Kryczyk-Poprawa A,Żmudzki P,Koczurkiewicz P,Pękala E,Hubicka U

    更新日期:2019-07-01 00:00:00

  • Cooperative phenomena in two-pulse, two-color laser photocoagulation of cutaneous blood vessels.

    abstract::A novel laser system has been developed to study the effects of multiple laser pulses of differing wavelengths on cutaneous blood vessels in vivo, using the hamster dorsal skin flap preparation and in vitro, using cuvettes of whole or diluted blood. The system permits sequenced irradiation with well-defined intrapulse...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0642:cpitpt>2.0.co;2

    authors: Barton JK,Frangineas G,Pummer H,Black JF

    更新日期:2001-06-01 00:00:00

  • Influence of human serum albumin on photodegradation of folic acid in solution.

    abstract::It has been proposed that photodegradation of folates may be the reason for the pigmentation of races living under high fluence rates of ultraviolet radiation. The photodegradation of folic acid (FA) induced by ultraviolet-A (UV-A) radiation, in solution and in the presence of human serum albumin (HSA), was studied wi...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2005-11-23-RA-739

    authors: Vorobey P,Steindal AE,Off MK,Vorobey A,Moan J

    更新日期:2006-05-01 00:00:00

  • UV released factors induce antioxidant defense in A375 cells.

    abstract::UV light leads to release of different secretory factors from irradiated cells of which some of them have been characterized. We have reported earlier that cells exposed to the supernatant medium from irradiated cells were resistant to killing by some genotoxic agents. In this study, we present our finding that demons...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01105.x

    authors: Ghosh R,Guha D,Bhowmik S

    更新日期:2012-05-01 00:00:00

  • Oculocutaneous albinism in sub-Saharan Africa: adverse sun-associated health effects and photoprotection.

    abstract::Oculocutaneous albinism (OCA) is a genetically inherited autosomal recessive condition. Individuals with OCA lack melanin and therefore are susceptible to the harmful effects of solar ultraviolet radiation, including extreme sun sensitivity, photophobia and skin cancer. OCA is a grave public health issue in sub-Sahara...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/php.12359

    authors: Wright CY,Norval M,Hertle RW

    更新日期:2015-01-01 00:00:00

  • Photodecomposition of vitamin A and photobiological implications for the skin.

    abstract::Vitamin A (retinol), an essential human nutrient, plays an important role in cellular differentiation, regulation of epidermal cell growth and normal cell maintenance. In addition to these physiological roles, vitamin A has a rich photochemistry. Photoisomerization of vitamin A, involved in signal transduction for vis...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1562/2006-10-23-IR-1065

    authors: Fu PP,Xia Q,Yin JJ,Cherng SH,Yan J,Mei N,Chen T,Boudreau MD,Howard PC,Wamer WG

    更新日期:2007-03-01 00:00:00

  • Identification and quantification of intrinsic optical contrast for near-infrared mammography.

    abstract::Near-infrared spectroscopy has been used to quantify the composition of healthy female breast tissue in vivo. By collecting transillumination spectra in the wavelength range 680-1100 nm at 7-9 positions on the breasts of five female volunteers, an attempt was made to quantify the intra- and intersubject variability of...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Quaresima V,Matcher SJ,Ferrari M

    更新日期:1998-01-01 00:00:00