Abstract:
:Tetracycline molecules offer several sites for peroxidative metabolism of the type known to lead to oxygen consumption and electronic excitation. Accordingly, when tetracycline and chlortetracycline were exposed to horseradish peroxidase in the presence of hydrogen peroxide, oxygen was taken up and light emission was observed. The overall quantum yield of chemiluminescence is on the order of 10(-6), but that of chemiexcitation may be orders of magnitude higher as suggested by studies of sensitized emission. Given the widespread distribution of peroxidases, the formation of highly reactive metabolites of tetracycline may have biological importance.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Gilio VE,Cilento Gdoi
10.1111/j.1751-1097.1993.tb09588.xsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
446-9issue
3eissn
0031-8655issn
1751-1097journal_volume
58pub_type
杂志文章abstract::Efficacy of ionizing radiation (I/R) was compared with phototoxic effects of photodynamic therapy (PDT) in vitro using two cell lines derived from patients with head and neck squamous cell carcinoma (HNSCC). A cell line derived from a donor with a human papilloma virus (HPV) infection was more responsive to I/R but si...
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