Light emission accompanies oxygen uptake during the peroxidative metabolism of tetracyclines.

Abstract:

:Tetracycline molecules offer several sites for peroxidative metabolism of the type known to lead to oxygen consumption and electronic excitation. Accordingly, when tetracycline and chlortetracycline were exposed to horseradish peroxidase in the presence of hydrogen peroxide, oxygen was taken up and light emission was observed. The overall quantum yield of chemiluminescence is on the order of 10(-6), but that of chemiexcitation may be orders of magnitude higher as suggested by studies of sensitized emission. Given the widespread distribution of peroxidases, the formation of highly reactive metabolites of tetracycline may have biological importance.

journal_name

Photochem Photobiol

authors

Gilio VE,Cilento G

doi

10.1111/j.1751-1097.1993.tb09588.x

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

446-9

issue

3

eissn

0031-8655

issn

1751-1097

journal_volume

58

pub_type

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