Abstract:
:This work evaluated the photoprotective and antigenotoxic effects against ultraviolet B (UVB) radiation of flavonoid compounds apigenin, naringenin and pinocembrin. The photoprotective efficacy of these compounds was estimated using in vitro photoprotection indices, and the antigenotoxicity against UVB radiation was evaluated using the SOS chromotest and an enzymatic (proteinase K/T4 endonuclease V enzyme) comet assay in UV-treated Escherichia coli and human (HEK-293) cells, respectively. Naringenin and pinocembrin showed maximum UV-absorption peak in UVC and UVB zones, while apigenin showed UV-absorption capability from UVC to UVA range. These compounds acted as UV filters reducing UV-induced genotoxicity, both in bacteria and in human cells. The enzymatic comet assay resulted highly sensitive for detection of UVB-induced DNA damage in HEK-293 cells. In this work, the photoprotective potential of these flavonoids was widely discussed.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
García Forero A,Villamizar Mantilla DA,Núñez LA,Ocazionez RE,Stashenko EE,Fuentes JLdoi
10.1111/php.13085subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1010-1018issue
4eissn
0031-8655issn
1751-1097journal_volume
95pub_type
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