Spectroscopic properties of potential sensitizers for new photodynamic therapy start mechanisms via two-step excited electronic states.

Abstract:

:Three substituted tetraazaporphyrins, octa-(4-tert-butylphenyl)-tetrapyrazinoporphyrazine, tetra-(4-tert-butyl)phthalocyanine and tetra-(4-tert-butyl)phthalocyanatomagnesium(t4-PcMg), were spectroscopically checked in solutions and liposomes with respect to suitability as potential sensitizers of a possible new start mechanism for photodynamic therapy (PDT) from a stepwise excited higher singlet state. This PDT start mechanism was recently proposed to overcome the problem of O2 (1delta2)-caused cutaneous phototoxicity in PDT. By means of absorption and fluorescence measurements as well as nonlinear absorption investigation, transient spectroscopy and lasing experiments, compound t4-PcMg was found to have the most appropriate properties: Based on a high fluorescence quantum yield (phiF1 = 0.84) and a very low crossing to the triplet (phiISC = 0.05), two higher excited states can be effectively populated both by two stepwise absorption transitions at 674nm consecutive absorption transitions at 684 and and 710 nm. Moreover, t4-PcMg incorporates into liposomes very well with spectroscopic properties similar to those in solution.

journal_name

Photochem Photobiol

authors

Teuchner K,Pfarrherr A,Stiel H,Freyer W,Leupold D

doi

10.1111/j.1751-1097.1993.tb02320.x

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

465-71

issue

3

eissn

0031-8655

issn

1751-1097

journal_volume

57

pub_type

杂志文章
  • Increasing Temperature Counteracts the Negative Effect of UV Radiation on Growth and Photosynthetic Efficiency of Microcystis aeruginosa and Raphidiopsis raciborskii.

    abstract::High temperature can promote cyanobacterial blooms, whereas ultraviolet radiation (UVR) can potentially depress cyanobacterial growth by damaging their photosynthetic apparatus. Although the damaging effect of UVR has been well documented, reports on the interactive effects of UV radiation exposure and warming on cyan...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13377

    authors: Noyma NP,Mesquita MCB,Roland F,Marinho MM,Huszar VLM,Lürling M

    更新日期:2021-01-04 00:00:00

  • Encapsulation of p-THPP into nanoparticles: cellular uptake, subcellular localization and effect of serum on photodynamic activity.

    abstract::The cellular uptake, localization and efflux of meso-tetra-(4-hydroxyphenyl)porphyrin (p-THPP)-loaded nanoparticles have been studied in EMT-6 tumor cells. The effect of blood serum on photocytotoxicity has also been evaluated. Sub-130 nm nanoparticles based on poly(D,L-lactide-co-glycolide) (PLGA) (50:50 PLGA and 75:...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2003)077<0638:eopinc>2.0.co;2

    authors: Konan YN,Chevallier J,Gurny R,Allémann E

    更新日期:2003-06-01 00:00:00

  • Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: a Double-blind, Randomized Placebo-controlled Clinical Study.

    abstract::Photoprotective formulations containing substances with antioxidant properties in combination have been used as a strategy for the improvement of photoaged skin conditions. However, there is a lack of studies evaluating the clinical efficacy of these substances in young women with signs of photoaging. Thus, the object...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13390

    authors: Fossa Shirata MM,Maia Campos PMBG

    更新日期:2021-02-02 00:00:00

  • Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: product studies using linoleic acid and 1,4-cyclohexadienes as model substrates.

    abstract::A careful study of the linoleic acid hydroperoxide (LOOH) profile obtained upon peroxidation of linoleic acid (LA) photosensitized by tiaprofenic acid (TPA) and analogous ketones has been undertaken to distinguish between type-I and type-II photoperoxidation mechanisms. 1,4-Cyclohexadiene and 1,2-dimethylcyclohexa-2,5...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0359:molppb>2.0.co;2

    authors: Samadi A,Martínez LA,Miranda MA,Morera IM

    更新日期:2001-04-01 00:00:00

  • Quantum efficiencies of the reversible photoreaction of octopus rhodopsin.

    abstract::The classic method of photometric curves for photosensitivity determination has been extended to the case of photoreversible reactions and applied to the octopus rhodopsin --> acid metarhodopsin photoreaction. In such cases, measurements at one irradiation wavelength yield the sum of the photosensitivities of the forw...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1987.tb04744.x

    authors: Dixon SF,Cooper A

    更新日期:1987-07-01 00:00:00

  • Photodynamic action of hematoporphyrin on yeast cells--a kinetic approach.

    abstract::By a technique which combines rapid mixing of cells and hematoporphyrin (HP) with a short duration of illumination, the photodynamic inactivation of yeast cells was investigated, particularly, in seeking for the information of the location of HP at the time of action. The fluence-survival curves obtained under the con...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Ito T

    更新日期:1981-10-01 00:00:00

  • Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01.

    abstract::Studies have reported the association of human leukocyte antigen (HLA) genes with susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no studies in Asian populations, including the Chinese. Our study was performed to determine if AP is associated with susceptibility or protective HLA alleles o...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12569

    authors: Chen Q,Shen M,Heng YK,Theng TSC,Tey HL,Ren EC,Chong WS

    更新日期:2016-03-01 00:00:00

  • Photodynamic activities and skin photosensitivity of the bis(dimethylthexylsiloxy)silicon 2,3-naphthalocyanine in mice.

    abstract::The photodynamic therapy (PDT) activity of the bis(dimethylthexylsiloxy)silicon 2,3-naphthalocyanine (SiNc 8) was evaluated against the EMT-6 tumor implanted intradermally in BALB/c mice. The SiNc 8 was formulated in aqueous emulsions based on Cremophor EL or Solutol HS 15. The formulation was shown to affect plasma c...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1995.tb02409.x

    authors: Brasseur N,Ouellet R,Lewis K,Potter WR,van Lier JE

    更新日期:1995-12-01 00:00:00

  • Biological weighting function for the mortality of Boeckella gracilipes (Copepoda, Crustacea) derived from experiments with natural solar radiation.

    abstract::We performed in situ experiments during the austral summer of 1998 to quantify the mortality of the fresh-water copepod Boeckella gracilipes as a function of the UV dose. The copepods were exposed to solar radiation at the water-surface for approximately 24-34 h. Long-pass cut-off filters (Schott) were used in the exp...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2000)072<0314:bwfftm>2.0.co;2

    authors: Tartarotti B,Cravero W,Zagarese HE

    更新日期:2000-09-01 00:00:00

  • Skin cancer risks avoided by the Montreal Protocol--worldwide modeling integrating coupled climate-chemistry models with a risk model for UV.

    abstract::The assessment model for ultraviolet radiation and risk "AMOUR" is applied to output from two chemistry-climate models (CCMs). Results from the UK Chemistry and Aerosols CCM are used to quantify the worldwide skin cancer risk avoided by the Montreal Protocol and its amendments: by the year 2030, two million cases of s...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01223.x

    authors: van Dijk A,Slaper H,den Outer PN,Morgenstern O,Braesicke P,Pyle JA,Garny H,Stenke A,Dameris M,Kazantzidis A,Tourpali K,Bais AF

    更新日期:2013-01-01 00:00:00

  • The hairless mouse model of photoaging: evaluation of the relationship between dermal elastin, collagen, skin thickness and wrinkles.

    abstract::Quantitative and qualitative changes in dermal collagen and elastin occur in response to chronic ultraviolet (UV) irradiation. These changes have been implicated in the genesis of the wrinkling seen in chronically irradiated, or photoaged skin. We examined the relationship between wrinkle formation and changes in derm...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1992.tb02194.x

    authors: Moloney SJ,Edmonds SH,Giddens LD,Learn DB

    更新日期:1992-10-01 00:00:00

  • The family of GFP-like proteins: structure, function, photophysics and biosensor applications. Introduction and perspective.

    abstract::In this issue, we offer a symposium-in-print that is focused on several new advancements in fundamental research related to the family of GFP (green fluorescent protein)-like proteins. A few applied aspects are also included to illustrate the impact this amazing set of colored proteins has made on our understanding of...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1562/2005-10-02-IR-708

    authors: Wachter RM

    更新日期:2006-03-01 00:00:00

  • Melanocortin 1 receptor variants: functional role and pigmentary associations.

    abstract::The significance of human cutaneous pigmentation lies in its protective role against sun-induced DNA damage and photocarcinogenesis. Fair skin and red hair are characterized by a low eumelanin to pheomelanin ratio, and have been associated with increased risk of skin cancer. Cutaneous pigmentation is a complex genetic...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.2011.00970.x

    authors: Dessinioti C,Antoniou C,Katsambas A,Stratigos AJ

    更新日期:2011-09-01 00:00:00

  • Chlorin-bacteriochlorin energy-transfer dyads as prototypes for near-infrared molecular imaging probes: controlling charge-transfer and fluorescence properties in polar media.

    abstract::The photophysical properties of two energy-transfer dyads that are potential candidates for near-infrared (NIR) imaging probes are investigated as a function of solvent polarity. The dyads (FbC-FbB and ZnC-FbB) contain either a free base (Fb) or zinc (Zn) chlorin (C) as the energy donor and a free base bacteriochlorin...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2008.00532.x

    authors: Kee HL,Diers JR,Ptaszek M,Muthiah C,Fan D,Lindsey JS,Bocian DF,Holten D

    更新日期:2009-07-01 00:00:00

  • p53 Mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator.

    abstract::In this study, we investigated whether the spectrum of p53 mutations in skin tumors induced in hairless SKH-hr1 mice by a solar simulator (290-400 nm) are similar to those found in skin tumors induced in C3H mice by UV radiation from unfiltered (250-400 nm) and Kodacel-filtered (290-400 nm) FS40 sunlamps. Analysis of ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(1998)067<0227:mihshm>2.3.co;2

    authors: Ananthaswamy HN,Fourtanier A,Evans RL,Tison S,Medaisko C,Ullrich SE,Kripke ML

    更新日期:1998-02-01 00:00:00

  • Reduced Levels of Tissue Inhibitors of Metalloproteinases in UVB-Irradiated Corneal Epithelium.

    abstract::Tissue inhibitors of metalloproteinases (TIMPs) are the major endogenous regulators of metalloproteinase activity in tissues. TIMPs are able to inhibit activity of all known matrix metalloproteinases (MMPs) and thus participate in controlling extracellular matrix synthesis and degradation. We showed previously elevate...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12612

    authors: Ardan T,Němcová L,Bohuslavová B,Klezlová A,Popelka Š,Studenovská H,Hrnčiarová E,Čejková J,Motlík J

    更新日期:2016-09-01 00:00:00

  • Ag Nanoparticles Connected to the Surface of TiO2 Electrostatically for Antibacterial Photoinactivation Studies.

    abstract::Supported silver nanoparticles (Ag NPs) were prepared by chemical reduction method with a sol-gel method. The structure, morphology, and interconnectivity of Ag/TiO2 nanocomposites (NCs) were analyzed using different instrumental techniques. Transmission electron microscopy reveals the Ag NPs have uniformly distribute...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12983

    authors: Deshmukh SP,Mullani SB,Koli VB,Patil SM,Kasabe PJ,Dandge PB,Pawar SA,Delekar SD

    更新日期:2018-11-01 00:00:00

  • Development of an in vitro system for the analysis of ultraviolet radiation-induced suppression of natural killer cell activity.

    abstract::Previous studies have shown that natural killer (NK) cell activity was suppressed in volunteer subjects exposed to ultraviolet radiation (UVR) from solarium lamps. The present studies were carried out to determine the spectrum of UVR responsible for suppression of NK activity and to develop in vitro methods to analyze...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1993.tb02287.x

    authors: Hersey P,Magrath H,Wilkinson F

    更新日期:1993-02-01 00:00:00

  • Safety and Clinical Impact of a Single Red Light Irradiation on Breast Tumor-Bearing Mice.

    abstract::Low-level light therapy has been used in health care as a therapeutic strategy for different diseases. However, its effects on cancer are controversial. This work evaluated the effects of three energies on breast cancer-bearing mice after a single red light-emitting diode (LED) irradiation. 4T1 cells were inoculated i...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13338

    authors: Pereira ST,Silva CR,Nuñez SC,Ribeiro MS

    更新日期:2020-10-03 00:00:00

  • Wavelength dependence of histological, physical, and visible changes in chronically UV-irradiated hairless mouse skin.

    abstract::Albino hairless mice (Skh: HR-1) exposed chronically to sub-erythemal doses of UV radiation display physical, visible and histological alterations. Using narrow bandwidth radiation covering the UV radiation spectrum from 280-380 nm, the wavelength dependence of these alterations was determined. The wavelength dependen...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb02907.x

    authors: Bissett DL,Hannon DP,Orr TV

    更新日期:1989-12-01 00:00:00

  • Factors affecting M13 bacteriophage inactivation by methylene blue photosensitization.

    abstract::We have investigated the factors that affect the virucidal activity of methylene blue (MB) photosensitization. The M13 bacteriophage was more rapidly inactivated at higher temperatures (6 degrees C < 24 degrees C < 38 degrees C). Rate constants for inactivation were 0.072, 0.139 and 0.260 (log10 inactivation)/ (J/cm2)...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb01937.x

    authors: Abe H,Wagner SJ,Kuwabara M,Kamo N,Ikebuchi K,Sekiguchi S

    更新日期:1997-05-01 00:00:00

  • Surface Functionalization of Green-synthesized Reduced Graphene Oxide with PPIX Enhances Photosensitization of Cancer Cells.

    abstract::Photosensitizer-functionalized reduced graphene oxide (rGO) nanoparticles are promising materials for photodynamic therapy in cancer management. In this study, rGO is synthesized by a green route employing glucose as the reducing agent and functionalized with photosensitizer, protoporphyrin IX (PPIX) in a convenient, ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13316

    authors: Shuvra Smita S,Das A,Barui A

    更新日期:2020-11-01 00:00:00

  • Radical cation generation from singlet and triplet excited states of all-trans-lycopene in chloroform.

    abstract::On direct photoexcitation, subpicosecond time-resolved absorption spectroscopy revealed that the 1B(u)-type singlet excited state of all-trans-lycopene in chloroform was about seven times more efficient than all-trans-beta-carotene in generating the radical cation. The time constant of radical cation generation from t...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2004-04-22-RA-147

    authors: Han RM,Wu YS,Feng J,Ai XC,Zhang JP,Skibsted LH

    更新日期:2004-09-01 00:00:00

  • Urokinase activity in corneal fibroblasts may be modulated by DNA damage and secreted proteins.

    abstract::Proteases like urokinase-type plasminogen activator (uPA) play an important role in tumor invasion. Cells derived from ultraviolet radiation (UVR)-induced corneal sarcomas of Monodelphis domestica produce relatively high levels of uPA compared to the untransformed keratocytes suggesting a mechanism for their invasiven...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0318:uaicfm>2.0.co;2

    authors: Green WB,McGuire PG,Miska KB,Kusewitt DF

    更新日期:2001-03-01 00:00:00

  • Heat and concentration effects on the small heat shock protein, alpha-crystallin.

    abstract::alpha-Crystallin, a major protein of the mammalian lens, plays a vital role in maintaining the structural stability and transparency of the lens. It performs this function through chaperone-like activity; it has recently been reported that heating alpha-crystallin enhances this ability. The present studies, using both...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2000)071<0470:haceot>2.0.co;2

    authors: Mandal K,Dillon J,Gaillard ER

    更新日期:2000-04-01 00:00:00

  • Solar UV exposure of seafarers along subtropical and tropical shipping routes.

    abstract::Seafarers working on decks of vessels at low latitudes are exposed to extremely high solar UV radiation. Their risk of developing skin cancer may be enhanced. Solar erythemal UV irradiance and exposure were measured for the first time on merchant vessels going along typical international routes at low latitudes. The m...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12144

    authors: Feister U,Meyer G,Kirst U

    更新日期:2013-11-01 00:00:00

  • Fluorescence polarization studies of B-phycoerythrin oriented in polymer film.

    abstract::Polarized steady-state fluorescence and fluorescence excitation spectra as well as time-resolved fluorescence for B-phycoerythrin (B-PE) from red algae, Porphyridium cruentum, embedded in polyvinyl stretched films were measured. The lifetimes of polarized fluorescence were analyzed using exponential components and fra...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Frackowiak D,Ptak A,Gryczynski Z,Gryczynski I,Targowski P,Zelent B

    更新日期:2004-01-01 00:00:00

  • Comparison of methylene blue and methylene violet for photoinactivation of intracellular and extracellular virus in red cell suspensions.

    abstract::Previous studies with methylene blue (MB) in red cell suspensions have demonstrated that extracellular, but not intracellular, virus can be readily photoinactivated. To test if the resistance of intracellular virus to inactivation is related to the permanent positive charge of the phenothiazine, a series of uncharged ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1997.tb08588.x

    authors: Skripchenko A,Robinette D,Wagner SJ

    更新日期:1997-03-01 00:00:00

  • Xanthene dyes induce membrane permeabilization of bacteria and erythrocytes by photoinactivation.

    abstract::We analyzed the photoinactivation of the membrane functions of bacteria and erythrocytes induced by xanthene dyes. The dyes tested were rose bengal, phloxine B, erythrosine B and eosin B. These dyes induced the leakage of K(+) from Staphylococcus aureus cells within minutes of photoirradiation, in the order of rose be...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01080.x

    authors: Kato H,Komagoe K,Nakanishi Y,Inoue T,Katsu T

    更新日期:2012-03-01 00:00:00

  • Detection of modified tyrosines as an inflammation marker in a photo-aged skin model.

    abstract::Reactive nitrogen species, produced during the process of inflammation induced by various factors including UV radiation, modify amino acids in crucial proteins. It is assumed that skin tissue is more likely to be modified, as it is located at the outer layer of a body that is exposed to UV radiation on a daily basis....

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2006-07-24-RA-978

    authors: Ishitsuka Y,Maniwa F,Koide C,Douzaki N,Kato Y,Nakamura Y,Osawa T

    更新日期:2007-05-01 00:00:00