Targeting of phototoxic drugs to antigen-specific T lymphocytes in vitro using antigen-presenting cell membranes.

abstract：:Nucleotide excision repair and the ATR-mediated DNA damage checkpoint are two critical cellular responses to the genotoxic stress induced by ultraviolet (UV) light and are important for cancer prevention. In vivo genetic data indicate that these global responses are coupled. Aziz Sancar et al. developed an in vitro co...

journal_title：Photochemistry and photobiology

authors： Lindsey-Boltz LA

更新日期：2017-01-01 00:00:00

abstract：:This study compares the abilities of the glutathione (GSH) and thioredoxin (Trx) antioxidant systems in defending cultured human lens epithelial cells (LECs) against UVA light. Levels of GSH were depleted with either L-buthionine-(S,R)-sulfoximine (BSO) or 1-chloro-2,4-dinitrobenzene (CDNB). CDNB treatment also inhibi...

journal_title：Photochemistry and photobiology

authors： Padgaonkar VA,Leverenz VR,Bhat AV,Pelliccia SE,Giblin FJ

更新日期：2015-03-01 00:00:00

abstract：:A careful study of the linoleic acid hydroperoxide (LOOH) profile obtained upon peroxidation of linoleic acid (LA) photosensitized by tiaprofenic acid (TPA) and analogous ketones has been undertaken to distinguish between type-I and type-II photoperoxidation mechanisms. 1,4-Cyclohexadiene and 1,2-dimethylcyclohexa-2,5...

journal_title：Photochemistry and photobiology

authors： Samadi A,Martínez LA,Miranda MA,Morera IM

更新日期：2001-04-01 00:00:00

abstract：:A 24 h preculture of HT29-18 human colonic adenocarcinoma cells with the sterol synthesis inhibitor lovastatin at concentrations of 0.1-0.5 microM markedly increased the photocytotoxic effect of photofrin II delivered to cells by low density lipoproteins. Under the same conditions, LDL binding and photofrin II (PII) u...

journal_title：Photochemistry and photobiology

authors： Biade S,Mazière JC,Mora L,Santus R,Mazière C,Auclair M,Morlière P,Dubertret L

更新日期：1993-02-01 00:00:00

abstract：:This study assessed the effects of photobiomodulation (PBM) to cells previously exposed to lipopolysaccharides (LPS). Human gingival fibroblasts (HGF) and epithelial cells (HaCaT) were seeded in wells of 24-well plates containing complete culture medium (DMEM). After 24 h, the DMEM was replaced by serum-free DMEM, and...

journal_title：Photochemistry and photobiology

authors： Pansani TN,Basso FG,Soares DG,Turrioni APDS,Hebling J,de Souza Costa CA

更新日期：2018-05-01 00:00:00

abstract：:Phototropin is a blue light-activated photoreceptor that plays a dominant role in the phototropism of plants. The protein contains two subunits that bind flavin mononucleotide (FMN), which are responsible for the initial steps of the light-induced reaction. It has been proposed that the photoexcited flavin molecule ad...

journal_title：Photochemistry and photobiology

authors： Neiss C,Saalfrank P

更新日期：2003-01-01 00:00:00

abstract：:The role of water molecules in spectral tuning of proteins has been left largely unexplored. This topic is important because changing hydrogen bond patterns during the activation process may lead to spectral shifts which can be of diagnostic value for the underlying structures. Arguments put forward in this article ar...

journal_title：Photochemistry and photobiology

authors： Sekharan S

更新日期：2009-03-01 00:00:00

abstract：:On direct photoexcitation, subpicosecond time-resolved absorption spectroscopy revealed that the 1B(u)-type singlet excited state of all-trans-lycopene in chloroform was about seven times more efficient than all-trans-beta-carotene in generating the radical cation. The time constant of radical cation generation from t...

journal_title：Photochemistry and photobiology

authors： Han RM,Wu YS,Feng J,Ai XC,Zhang JP,Skibsted LH

更新日期：2004-09-01 00:00:00

abstract：:We used GHz frequency-domain fluorometry to investigate the time-dependent intensity decays of N-acetyl-L-trytophanamide (NATA) when collisionally quenched by acrylamide in propylene glycol at 20 degrees C. The intensity decays of NATA became increasingly heterogeneous in the presence of acrylamide. The NATA intensity...

journal_title：Photochemistry and photobiology

authors： Lakowicz JR,Zelent B,Gryczynski I,Kuśba J,Johnson ML

更新日期：1994-09-01 00:00:00

abstract：:The interaction between human alpha1-acid glycoprotein (orosomucoid) and the fluorescent probe, 2-p-toluidinylnaphthalene-6-sulfonate (TNS) has been studied. An association constant of 16.7 (+/- 3) x 10(3) M-1 was obtained for the complex at 20 degrees C with a stoichiometry of 1:1. From the effect of temperature on t...

journal_title：Photochemistry and photobiology

authors： Albani J,Vos R,Willaert K,Engelborghs Y

更新日期：1995-07-01 00:00:00

abstract：:Because metallothionein (MT) is elevated and may be protective in UV-irradiated skin, we have studied the effects of UV and other agents on MT transcription using the sheep MT 1A promoter, linked to the beta-galactosidase gene and stably transfected into human cell lines. beta-galactosidase reporter activity was induc...

journal_title：Photochemistry and photobiology

authors： Hansen C,Ablett E,Green A,Sturm RA,Dunn IS,Fairlie DP,West ML,Parsons PG

更新日期：1997-03-01 00:00:00

abstract：:The effect of cucurbit[7]uril (CB7) on the spiropyran-merocyanine photochromic interconversion was studied in acidic and alkaline aqueous solutions. The merocyanine (MC) isomer was found to be the thermodynamically most stable form both in water and in the presence of CB7. A preferential binding of the protonated mero...

journal_title：Photochemistry and photobiology

authors： Miskolczy Z,Biczók L

更新日期：2012-11-01 00:00:00

abstract：:The ultraviolet (UV) component of solar radiation is the driving force of life on earth, but it can cause photoaging and skin cancer. In this study, we investigated the effects of the glucosamine-derivative 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-β-D-glucose (NAPA) on human primary fibroblasts (FBs) stimulated in vit...

journal_title：Photochemistry and photobiology

authors： Lopreiato M,Cocchiola R,Falcucci S,Leopizzi M,Cardone M,Di Maio V,Brocco U,D'Orazi V,Calvieri S,Scandurra R,De Marco F,Scotto d'Abusco A

更新日期：2020-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are involved in the control of virtually all aspects of our behavior and physiology. Activated receptors catalyze nucleotide exchange in heterotrimeric G proteins (composed of alpha.GDP, beta and gamma subunits) on the inner surface of the cell membrane. The GPCR rhodopsin and the G...

journal_title：Photochemistry and photobiology

authors： Chen Y,Herrmann R,Fishkin N,Henklein P,Nakanishi K,Ernst OP

更新日期：2008-07-01 00:00:00

abstract：:Photodamage to the endoplasmic reticulum (ER) can initiate a death pathway termed paraptosis. The "canonical" model of paraptosis, initiated by certain drugs and other stimuli, requires a brief interval of protein synthesis, involves the action of MAP kinases and can be followed by biochemical markers. The latter incl...

journal_title：Photochemistry and photobiology

authors： Kessel D

更新日期：2020-09-01 00:00:00

abstract：:A novel laser system has been developed to study the effects of multiple laser pulses of differing wavelengths on cutaneous blood vessels in vivo, using the hamster dorsal skin flap preparation and in vitro, using cuvettes of whole or diluted blood. The system permits sequenced irradiation with well-defined intrapulse...

journal_title：Photochemistry and photobiology

authors： Barton JK,Frangineas G,Pummer H,Black JF

更新日期：2001-06-01 00:00:00

abstract：:Continuous red light controls starch degradation in turions of Spirodela polyrhiza [Dölger, K., U. K. Tirlapur and K.-J. Appenroth [1997] Photochem. Photobiol. 66, 126-127 (1997)]. This light could be replaced by repeated red light pulses with the reciprocity law fulfilled over a large range of fluence rates. The effe...

journal_title：Photochemistry and photobiology

authors： Appenroth KJ,Gabrys H

更新日期：2001-01-01 00:00:00

abstract：:During the photoreaction cycle of photoactive yellow protein (PYP), a physiologically active intermediate (PYP(M)) is formed as a consequence of global protein conformational change. Previous studies have demonstrated that the photocycle of PYP is regulated by the N-terminal loop region, which is located across the ce...

journal_title：Photochemistry and photobiology

authors： Harigai M,Kataoka M,Imamoto Y

更新日期：2008-07-01 00:00:00

abstract：:More scheduled outdoor stay is increasingly advocated for school children. This study measured 2(nd) , 5(th) and 8(th) graders' erythemal UV-exposure in September, March and May at four Swedish schools. We related those exposures, as fractions of total available ambient radiation, to the schools outdoor environments d...

journal_title：Photochemistry and photobiology

authors： Pagels P,Wester U,Söderström M,Lindelöf B,Boldemann C

更新日期：2016-01-01 00:00:00

abstract：:We investigated the effect of the cation-π interaction on the susceptibility of a tryptophan model system toward interaction with singlet oxygen, that is, type II photooxidation. The model system consists of two indole units linked to a lariat crown ether to measure the total rate of removal of singlet oxygen by the i...

journal_title：Photochemistry and photobiology

authors： Arevalo GE,Cagan DA,Monsour CG,Garcia AC,McCurdy A,Selke M

更新日期：2020-11-01 00:00:00

abstract：:Studies have reported the association of human leukocyte antigen (HLA) genes with susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no studies in Asian populations, including the Chinese. Our study was performed to determine if AP is associated with susceptibility or protective HLA alleles o...

journal_title：Photochemistry and photobiology

authors： Chen Q,Shen M,Heng YK,Theng TSC,Tey HL,Ren EC,Chong WS

更新日期：2016-03-01 00:00:00

abstract：:Exploration of environmental dynamics using intrinsic biological probe tryptophan is very important; however, it suffers from various difficulties. An alternative probe, kynurenine (KN), has been found to be an efficient probe for the ultrafast dynamics in the biological environment (Goswami et al., [2010] J. Phys. Ch...

journal_title：Photochemistry and photobiology

authors： Rakshit S,Goswami N,Pal SK

更新日期：2012-01-01 00:00:00

abstract：:Room temperature phosphorescence (RTP) of three palladium (Pd)-phorphyrins in air-saturated solution of sodium deoxycholate (NaDC) aggregates was measured. RTP of Pd-meso-tetrakis (4-carboxyphenyl) porphyrin (Pd-TCPP) was obviously enhanced in NaDC-aggregates mediated by alkaline earth metal (AEM). Under the same expe...

journal_title：Photochemistry and photobiology

authors： Wang YT,Wang XW,Zhang Y

更新日期：2011-07-01 00:00:00

abstract：:To determine the origin of the UV-specific CC to TT tandem mutation at the CC site, we made a duplex DNA decamer containing a uracil cis-syn cyclobutane dimer (CBD) as the deaminated model of a cytosine dimer. Two-dimensional 1H-NMR spectroscopy studies were performed on this sequence where two adenines (Ade) were opp...

journal_title：Photochemistry and photobiology

authors： Lee HM,Kim JK

更新日期：2002-10-01 00:00:00

abstract：:It was shown that psoralen + UV-A inhibits the chemotactic activity of polymorphonuclear neutrophils towards anaphylatoxin C5a des Arg. This reaction required oxygen and there is a high possibility that the active oxygen species was in a singlet state. Oxygen did not act directly on C5a des Arg, but rather produced ox...

journal_title：Photochemistry and photobiology

authors： Esaki K,Mizuno N

更新日期：1992-05-01 00:00:00

abstract：:Structure-activity relationships have been widely reported for porphyrin and phthalocyanine photosensitizers, but not for phenothiazinium derivatives. Here, four phenothiazinium salts (methylene blue, toluidine blue O, 1,9-dimethyl methylene blue and the pentacyclic derivative DO15) were used to investigate how the ab...

journal_title：Photochemistry and photobiology

authors： Bacellar IO,Pavani C,Sales EM,Itri R,Wainwright M,Baptista MS

更新日期：2014-07-01 00:00:00

abstract：:Uveal melanoma is the most frequent intraocular cancer and the second most common form of melanoma. It metastasizes in half of the patients and the prognostic is poor. Although ultraviolet (UV) radiation is a proven risk factor for skin melanoma, the role of UV light in the etiology of uveal melanoma is still contradi...

journal_title：Photochemistry and photobiology

authors： Mallet JD,Gendron SP,Drigeard Desgarnier MC,Rochette PJ

更新日期：2014-01-01 00:00:00

abstract：:Channel and pump rhodopsins use energy from light absorbed by a covalently bound retinal chromophore to transport ions across membranes of microbial cells. Ion transfer steps, including proton transfer, can couple to changes in protein conformational dynamics and water positions. Although general principles of how mic...

journal_title：Photochemistry and photobiology

authors： Bondar AN,Smith JC

更新日期：2017-11-01 00:00:00

abstract：:Syntheses for the new photosensitizers HOSiPcOSi(CH3)2(CH2)3N(CH1)1 or 3(CH3)2, Pc 34 and Pc 25, have been developed and the order of activity of these photosensitizers and the previously reported photosensitizer Pc 4, HOSiPcOSi(CH3)2(CH2)3N(CH3)2, in the dark and with broad-band red light toward Plasmodium falciparum...

journal_title：Photochemistry and photobiology

authors： Zhao XJ,Lustigman S,Li YS,Kenney ME,Ben-Hur E

更新日期：1997-08-01 00:00:00

abstract：:The thermodynamic parameters for the formation of the free radicals upon electron transfer quenching of the flavin triplet state (3FMN) by tryptophan and tyrosine, Delta(FR)H and Delta(FR)V, were obtained in aqueous solution by the application of laser-induced optoacoustic spectroscopy at various temperatures. The Del...

journal_title：Photochemistry and photobiology

authors： Crovetto L,Martínez-Junza V,Braslavsky SE

更新日期：2006-01-01 00:00:00