Lovastatin potentiates the photocytotoxic effect of photofrin II delivered to HT29 human colonic adenocarcinoma cells by low density lipoprotein.

Abstract:

:A 24 h preculture of HT29-18 human colonic adenocarcinoma cells with the sterol synthesis inhibitor lovastatin at concentrations of 0.1-0.5 microM markedly increased the photocytotoxic effect of photofrin II delivered to cells by low density lipoproteins. Under the same conditions, LDL binding and photofrin II (PII) uptake by HT29 cells increased about 1.8-fold and 1.5-fold, respectively. These results suggest that hydroxymethylglutaryl-coenzyme A reductase inhibitors could be useful for potentiating the photodynamic therapy of tumors by PII.

journal_name

Photochem Photobiol

authors

Biade S,Mazière JC,Mora L,Santus R,Mazière C,Auclair M,Morlière P,Dubertret L

doi

10.1111/j.1751-1097.1993.tb02303.x

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

371-5

issue

2

eissn

0031-8655

issn

1751-1097

journal_volume

57

pub_type

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